PMID- 37951951
OWN - NLM
STAT- MEDLINE
DCOM- 20231113
LR  - 20231122
IS  - 2158-3188 (Electronic)
IS  - 2158-3188 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Nov 11
TI  - A brain model of altered self-appraisal in social anxiety disorder.
PG  - 344
LID - 10.1038/s41398-023-02644-7 [doi]
LID - 344
AB  - The brain's default mode network has a central role in the processing of 
      information concerning oneself. Dysfunction in this self-referential processing 
      represents a key component of multiple mental health conditions, particularly 
      social anxiety disorder (SAD). This case-control study aimed to clarify 
      alterations to network dynamics present during self-appraisal in SAD 
      participants. A total of 38 adolescents and young adults with SAD and 72 healthy 
      control participants underwent a self-referential processing fMRI task. The task 
      involved two primary conditions of interest: direct self-appraisal (thinking 
      about oneself) and reflected self-appraisal (thinking about how others might 
      think about oneself). Dynamic causal modeling and parametric empirical Bayes were 
      then used to explore differences in the effective connectivity of the default 
      mode network between groups. We observed connectivity differences between SAD and 
      healthy control participants in the reflected self-appraisal but not the direct 
      self-appraisal condition. Specifically, SAD participants exhibited greater 
      excitatory connectivity from the posterior cingulate cortex (PCC) to medial 
      prefrontal cortex (MPFC) and greater inhibitory connectivity from the inferior 
      parietal lobule (IPL) to MPFC. In contrast, SAD participants exhibited reduced 
      intrinsic connectivity in the absence of task modulation. This was illustrated by 
      reduced excitatory connectivity from the PCC to MPFC and reduced inhibitory 
      connectivity from the IPL to MPFC. As such, participants with SAD showed changes 
      to afferent connections to the MPFC which occurred during both reflected 
      self-appraisal as well as intrinsically. The presence of connectivity differences 
      in reflected and not direct self-appraisal is consistent with the characteristic 
      fear of negative social evaluation that is experienced by people with SAD.
CI  - (c) 2023. The Author(s).
FAU - Jamieson, Alec J
AU  - Jamieson AJ
AUID- ORCID: 0000-0002-5598-0240
AD  - Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia. 
      alec.jamieson@unimelb.edu.au.
FAU - Harrison, Ben J
AU  - Harrison BJ
AD  - Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia.
FAU - Delahoy, Rebekah
AU  - Delahoy R
AD  - Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia.
FAU - Schmaal, Lianne
AU  - Schmaal L
AD  - Orygen, Parkville, VIC, Australia.
AD  - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, 
      Australia.
FAU - Felmingham, Kim L
AU  - Felmingham KL
AD  - Melbourne School of Psychological Sciences, The University of Melbourne, 
      Parkville, VIC, Australia.
FAU - Phillips, Lisa
AU  - Phillips L
AUID- ORCID: 0000-0003-1060-6068
AD  - Melbourne School of Psychological Sciences, The University of Melbourne, 
      Parkville, VIC, Australia.
FAU - Davey, Christopher G
AU  - Davey CG
AUID- ORCID: 0000-0003-1431-3852
AD  - Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia. 
      c.davey@unimelb.edu.au.
LA  - eng
GR  - 1064643/Department of Health | National Health and Medical Research Council 
      (NHMRC)/
GR  - 1145010/Department of Health | National Health and Medical Research Council 
      (NHMRC)/
GR  - 1124472/Department of Health | National Health and Medical Research Council 
      (NHMRC)/
GR  - 1141738/Department of Health | National Health and Medical Research Council 
      (NHMRC)/
PT  - Journal Article
DEP - 20231111
PL  - United States
TA  - Transl Psychiatry
JT  - Translational psychiatry
JID - 101562664
SB  - IM
MH  - Young Adult
MH  - Adolescent
MH  - Humans
MH  - *Phobia, Social/diagnostic imaging
MH  - Diagnostic Self Evaluation
MH  - Case-Control Studies
MH  - Bayes Theorem
MH  - Magnetic Resonance Imaging
MH  - Gyrus Cinguli
MH  - Brain/diagnostic imaging
MH  - Brain Mapping
PMC - PMC10640593
COIS- The authors declare no competing interests.
EDAT- 2023/11/12 00:42
MHDA- 2023/11/13 06:42
PMCR- 2023/11/11
CRDT- 2023/11/11 23:22
PHST- 2023/06/01 00:00 [received]
PHST- 2023/10/30 00:00 [accepted]
PHST- 2023/10/23 00:00 [revised]
PHST- 2023/11/13 06:42 [medline]
PHST- 2023/11/12 00:42 [pubmed]
PHST- 2023/11/11 23:22 [entrez]
PHST- 2023/11/11 00:00 [pmc-release]
AID - 10.1038/s41398-023-02644-7 [pii]
AID - 2644 [pii]
AID - 10.1038/s41398-023-02644-7 [doi]
PST - epublish
SO  - Transl Psychiatry. 2023 Nov 11;13(1):344. doi: 10.1038/s41398-023-02644-7.