PMID- 37953101
OWN - NLM
STAT- MEDLINE
DCOM- 20231201
LR  - 20231201
IS  - 1460-9584 (Electronic)
IS  - 1268-7731 (Linking)
VI  - 29
IP  - 8
DP  - 2023 Dec
TI  - Purple sweet potato (Ipomoea batatas L.) extract effects on levels of 
      inflammatory markers and chondrocyte count in gout arthritis Wistar rat model.
PG  - 611-615
LID - S1268-7731(23)00135-2 [pii]
LID - 10.1016/j.fas.2023.07.007 [doi]
AB  - BACKGROUND: Recently, herbal medicine has become alternative in management of 
      gout. Our aim is to assess effectiveness of purple sweet potato extract in gout. 
      METHOD: In vivo study with randomized posttest only control group design. Purple 
      sweet potato extract administered to 16 Wistar rats with MSU-induced gout. 
      Independent t-test for analyzing interleukin-1 beta (IL-1beta), matrix 
      metalloproteinase-3 (MMP-3), cartilage oligomeric matrix protein (COMP), 
      malondialdehyde (MDA), and number of chondrocytes results. RESULTS: Decreased 
      level of IL-1beta (3.81 +/- 1.54 ng/mL vs. 2.55 +/- 0.59 ng/mL, p = 0.04), MDA 
      (5.04 +/- 1.02 ng/mL vs. 2.27 +/- 0.57 ng/mL, p = 0.04), MMP-3 (5.66 +/- 1.02 ng/mL vs. 
      3.84 +/- 1.37 ng/mL, p = 0.01) COMP (21.01 +/- 3.57 ng/mL vs. 17.27 +/- 2.60 ng/mL, p = 
      0.03), and increasing chondrocytes (35.17 +/- 12.35 lp vs. 48.56 +/- 7.17 lp, p = 
      0.02). CONCLUSION: Purple sweet potato extract with anthocyanin inhibits 
      inflammation and cartilage degeneration in gout. LEVEL OF EVIDENCE: Level 1.
CI  - Copyright (c) 2023. Published by Elsevier Ltd.
FAU - Subawa, I Wayan
AU  - Subawa IW
AD  - Dept. Orthopaedic & Traumatology, Prof dr IGNG Ngoerah General Hospital, Faculty 
      of Medicine, Udayana University, Bali, Indonesia. Electronic address: 
      iwayansubawa1976@gmail.com.
FAU - Astawa, Putu
AU  - Astawa P
AD  - Dept. Orthopaedic & Traumatology, Prof dr IGNG Ngoerah General Hospital, Faculty 
      of Medicine, Udayana University, Bali, Indonesia.
FAU - Bakta, I Made
AU  - Bakta IM
AD  - Dept. Internal Medicine, Prof dr IGNG Ngoerah General Hospital, Faculty of 
      Medicine, Udayana University, Bali, Indonesia.
FAU - Astawa, I Nyoman Mantik
AU  - Astawa INM
AD  - Faculty of Veterinary Medicine, Udayana University, Bali, Indonesia.
FAU - Krisna, Gede Aditya
AU  - Krisna GA
AD  - Dept. Orthopaedic & Traumatology, Prof dr IGNG Ngoerah General Hospital, Faculty 
      of Medicine, Udayana University, Bali, Indonesia.
LA  - eng
PT  - Journal Article
DEP - 20230720
PL  - France
TA  - Foot Ankle Surg
JT  - Foot and ankle surgery : official journal of the European Society of Foot and 
      Ankle Surgeons
JID - 9609647
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Rats
MH  - Animals
MH  - Humans
MH  - Rats, Wistar
MH  - *Ipomoea batatas/metabolism
MH  - Matrix Metalloproteinase 3/metabolism
MH  - Chondrocytes
MH  - Plant Extracts/pharmacology/therapeutic use/metabolism
MH  - *Gout
OTO - NOTNLM
OT  - Articular cartilage
OT  - Gout
OT  - Inflammation
OT  - Ipomoea batatas L.
OT  - Purple sweet potato
COIS- Declaration of Competing Interest There are no known competing financial 
      interests or personal relationships that could have appeared to influence the 
      work reported in this paper.
EDAT- 2023/11/13 00:41
MHDA- 2023/12/01 06:44
CRDT- 2023/11/12 21:54
PHST- 2023/05/09 00:00 [received]
PHST- 2023/07/18 00:00 [accepted]
PHST- 2023/12/01 06:44 [medline]
PHST- 2023/11/13 00:41 [pubmed]
PHST- 2023/11/12 21:54 [entrez]
AID - S1268-7731(23)00135-2 [pii]
AID - 10.1016/j.fas.2023.07.007 [doi]
PST - ppublish
SO  - Foot Ankle Surg. 2023 Dec;29(8):611-615. doi: 10.1016/j.fas.2023.07.007. Epub 
      2023 Jul 20.