PMID- 37954110
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231114
IS  - 2364-3722 (Print)
IS  - 2196-9736 (Electronic)
IS  - 2196-9736 (Linking)
VI  - 11
IP  - 11
DP  - 2023 Nov
TI  - Cold snare polypectomy for duodenal adenomas in familial adenomatous polyposis: a 
      prospective international cohort study.
PG  - E1056-E1062
LID - 10.1055/a-2165-7436 [doi]
AB  - Background and study aims In patients with familial adenomatous polyposis (FAP), 
      endoscopic resection of duodenal adenomas is commonly performed to prevent cancer 
      and prevent or defer duodenal surgery. However, based on studies using different 
      resection techniques, adverse events (AEs) of polypectomy in the duodenum can be 
      significant. We hypothesized that cold snare polypectomy (CSP) is a safe 
      technique for duodenal adenomas in FAP and evaluated its outcomes in our centers. 
      Patients and methods We performed a prospective international cohort study 
      including FAP patients who underwent CSP for one or more superficial 
      non-ampullary duodenal adenomas of any size between 2020 and 2022. At that time, 
      this technique was common practice in our centers for superficial duodenal 
      adenomas. The primary outcome was the occurrence of intraprocedural and 
      post-procedural AEs. Results In total, 133 CSPs were performed in 39 patients 
      with FAP (1-18 per session). Median adenoma size was 10 mm (interquartile range 
      8-15 mm), ranging from 5 to 40 mm; 27 adenomas were >/=20 mm (20%). Of the 133 
      polypectomies, 109 (82%) were performed after submucosal injection. Sixty-one 
      adenomas (46%) were resected en bloc and 72 (54%) piecemeal. Macroscopic radical 
      resection was achieved for 129 polypectomies (97%). Deep mural injury type II 
      occurred in three polyps (2%) with no delayed perforation after prophylactic 
      clipping. There were no clinically significant bleeds, perforations or other 
      post-procedural AEs. Histopathology showed low-grade dysplasia in all 133 
      adenomas. Conclusions CSP for (multiple) superficial non-ampullary duodenal 
      adenomas in FAP seems feasible and safe. Long-term prospective research is needed 
      to evaluate whether protocolized duodenal polypectomies prevent cancer and 
      surgery.
CI  - The Author(s). This is an open access article published by Thieme under the terms 
      of the Creative Commons Attribution License, permitting unrestricted use, 
      distribution, and reproduction so long as the original work is properly cited. 
      (https://creativecommons.org/licenses/by/4.0/).
FAU - Aelvoet, Arthur S
AU  - Aelvoet AS
AUID- ORCID: 0000-0002-1991-1117
AD  - Department of Gastroenterology and Hepatology, Amsterdam UMC location University 
      of Amsterdam, Amsterdam, the Netherlands. RINGGOLD: 1234
AD  - Cancer Center Amsterdam, Amsterdam, the Netherlands.
AD  - Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands. 
      RINGGOLD: 1234
FAU - Karstensen, John G
AU  - Karstensen JG
AUID- ORCID: 0000-0001-9333-0399
AD  - Gastrounit, Copenhagen University Hospital - Amager and Hvidovre, Danish 
      Polyposis Registry, Hvidovre, Denmark. RINGGOLD: 53137
AD  - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. 
      RINGGOLD: 4321
FAU - Bastiaansen, Barbara A J
AU  - Bastiaansen BAJ
AD  - Department of Gastroenterology and Hepatology, Amsterdam UMC location University 
      of Amsterdam, Amsterdam, the Netherlands. RINGGOLD: 1234
AD  - Cancer Center Amsterdam, Amsterdam, the Netherlands.
AD  - Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands. 
      RINGGOLD: 1234
FAU - van Leerdam, Monique E
AU  - van Leerdam ME
AD  - Department of Gastrointestinal Oncology, Netherlands Cancer Institute, Amsterdam, 
      the Netherlands.
AD  - Department of Gastroenterology and Hepatology, Leiden University Medical Center, 
      Leiden, the Netherlands. RINGGOLD: 4501
FAU - Balaguer, Francesc
AU  - Balaguer F
AD  - Department of Gastroenterology, Institut d'Investigacions Biomediques August Pi i 
      Sunyer (IDIBAPS), Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), University of Barcelona, Hospital Clinic de 
      Barcelona, Barcelona, Spain.
FAU - Kaminski, Michal
AU  - Kaminski M
AD  - Department of Oncological Gastroenterology and Department of Cancer Prevention, 
      Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
FAU - Hompes, Roel
AU  - Hompes R
AD  - Department of Surgery, Amsterdam UMC location University of Amsterdam, Amsterdam, 
      the Netherlands.
AD  - Cancer Center Amsterdam, Amsterdam, the Netherlands.
FAU - Bossuyt, Patrick M M
AU  - Bossuyt PMM
AD  - Department of Epidemiology and Data Science, Amsterdam UMC location University of 
      Amsterdam, Amsterdam, the Netherlands. RINGGOLD: 26066
FAU - Ricciardiello, Luigi
AU  - Ricciardiello L
AD  - Policlinico di Sant'Orsola, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 
      Bologna, Italy.
AD  - Department of Medical and Surgical Sciences, University of Bologna, Bologna, 
      Italy. RINGGOLD: 9296
FAU - Latchford, Andrew
AU  - Latchford A
AUID- ORCID: 0000-0002-8626-188X
AD  - Polyposis Registry, St Mark's Hospital, Harrow, United Kingdom.
AD  - Department of Surgery and Cancer, Imperial College London, London, United 
      Kingdom. RINGGOLD: 4615
FAU - Jover, Rodrigo
AU  - Jover R
AD  - Instituto de Investigacion Biomedica ISABIAL, Universidad Miguel Hernandez, 
      Servicio de Medicina Digestiva, Hospital General Universitario de Alicante, 
      Alicante, Spain. RINGGOLD: 16802
FAU - Daca-Alvarez, Maria
AU  - Daca-Alvarez M
AUID- ORCID: 0000-0001-5636-8865
AD  - Department of Gastroenterology, Institut d'Investigacions Biomediques August Pi i 
      Sunyer (IDIBAPS), Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), University of Barcelona, Hospital Clinic de 
      Barcelona, Barcelona, Spain.
FAU - Pellise, Maria
AU  - Pellise M
AUID- ORCID: 0000-0001-9739-4998
AD  - Department of Gastroenterology, Institut d'Investigacions Biomediques August Pi i 
      Sunyer (IDIBAPS), Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas (CIBEREHD), University of Barcelona, Hospital Clinic de 
      Barcelona, Barcelona, Spain.
FAU - Dekker, Evelien
AU  - Dekker E
AUID- ORCID: 0000-0002-4363-0745
AD  - Department of Gastroenterology and Hepatology, Amsterdam UMC location University 
      of Amsterdam, Amsterdam, the Netherlands. RINGGOLD: 1234
AD  - Cancer Center Amsterdam, Amsterdam, the Netherlands.
AD  - Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands. 
      RINGGOLD: 1234
CN  - European FAP Consortium
LA  - eng
PT  - Journal Article
DEP - 20231110
PL  - Germany
TA  - Endosc Int Open
JT  - Endoscopy international open
JID - 101639919
PMC - PMC10637860
OTO - NOTNLM
OT  - Duodenal polyposis
OT  - Endoscopic resection
OT  - Familial adenomatous polyposis
COIS- Conflict of Interest Arthur S. Aelvoet: none to declare. John G. Karstensen: JGK 
      consultancy for SNIPR BIOME, Boston Scientific, and AMBU and speaker's fee from 
      Norgine. Barbara A.J. Bastiaansen: speaker's fee from Olympus, Tillotts Pharma AG 
      and Ovesco Endoscopy AG. Monique van Leerdam: review and editorial fee from 
      Elsevier Francesc Balaguer: FB has received an honorarium for consultancy from 
      Sysmex, CPP Pharmaceuticals, and One-Two Therapeutics, speaker's fees from 
      Norgine, and editorial fee from Elsevier. Michal Kaminski: speaker's fee from 
      Olympus, Fujifilm, Boston Scientific, Medtronic, AlfaSigma, IPSEN, consultancy 
      fee from Olympus, ERBE, AlfaSigma. Roel Hompes: none to declare. Patrick M.M. 
      Bossuyt: none to declare. Luigi Ricciardiello: consultancy and unrestricted 
      research grant from SLA Pharma AG. Andrew Latchford: none to declare. Rodrigo 
      Jover: consultancy for CPP Pharmaceuticals Maria Daca-Alvarez: none to declare. 
      Maria Pellise: endoscopic equipment on loan of FujiFilm, research grant from 
      FujiFilm, ZiuZ and Casen Recordati, consultancy for FujiFilm, Olympus and 
      speaker's fee from Olympus, Medtronic and FujiFilm. Evelien Dekker: endoscopic 
      equipment on loan of FujiFilm and Olympus, research grant from FujiFilm, 
      consultancy for FujiFilm, Olympus, Ambu and InterVenn, and speaker's fee from 
      Olympus, GI Supply, Norgine, IPSEN, PAION and FujiFilm.
EDAT- 2023/11/13 06:43
MHDA- 2023/11/13 06:44
PMCR- 2023/11/01
CRDT- 2023/11/13 04:24
PHST- 2023/06/12 00:00 [received]
PHST- 2023/08/28 00:00 [accepted]
PHST- 2023/11/13 06:44 [medline]
PHST- 2023/11/13 06:43 [pubmed]
PHST- 2023/11/13 04:24 [entrez]
PHST- 2023/11/01 00:00 [pmc-release]
AID - EIO-2023-06-3050-OA [pii]
AID - 10.1055/a-2165-7436 [doi]
PST - epublish
SO  - Endosc Int Open. 2023 Nov 10;11(11):E1056-E1062. doi: 10.1055/a-2165-7436. 
      eCollection 2023 Nov.