PMID- 37954278
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231114
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 9
IP  - 11
DP  - 2023 Nov
TI  - A review: Mechanism and prospect of gastrodin in prevention and treatment of T2DM 
      and COVID-19.
PG  - e21218
LID - 10.1016/j.heliyon.2023.e21218 [doi]
LID - e21218
AB  - Gastrodin is an extract from the dried tuber of the Chinese herb Gastrodia elata 
      (Tian ma), with anti-inflammatory, antioxidant, and antiviral properties. Recent 
      studies have shown that, compared to commonly used diabetes drugs, gastrodin has 
      antidiabetic effects in multiple ways, with characteristics of low cost, high 
      safety, less side effects, protection of beta-cell function, relieving insulin 
      resistance and alleviating multiple complications. In addition, it is confirmed 
      that gastrodin can protect the function of lung and other organs, enhance 
      antiviral activity via upregulating the type I interferon (IFN-I), and inhibit 
      angiotensin II (AngII), a key factor in "cytokine storm" caused by COVID-19. 
      Therefore, we reviewed the effect and mechanism of gastrodin on type 2 diabetes 
      mellitus (T2DM), and speculated other potential mechanisms of gastrodin in 
      alleviating insulin resistance from insulin signal pathway, inflammation, 
      mitochondrial and endoplasmic reticulum and its potential in the prevention and 
      treatment of COVID-19. We hope to provide new direction and treatment strategy 
      for basic research and clinical work: gastrodin is considered as a drug for the 
      prevention and treatment of diabetes and COVID-19.
CI  - (c) 2023 The Authors.
FAU - Li, Yi
AU  - Li Y
AD  - Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, China.
FAU - Ji, Yuanyuan
AU  - Ji Y
AD  - Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, China.
FAU - Li, Fenglan
AU  - Li F
AD  - Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231026
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC10637887
OTO - NOTNLM
OT  - Anti-inflammation
OT  - Anti-oxidation
OT  - Antivirus
OT  - COVID-19
OT  - Gastrodin
OT  - T2DM
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2023/11/13 06:42
MHDA- 2023/11/13 06:43
PMCR- 2023/10/26
CRDT- 2023/11/13 04:28
PHST- 2023/04/11 00:00 [received]
PHST- 2023/09/15 00:00 [revised]
PHST- 2023/10/18 00:00 [accepted]
PHST- 2023/11/13 06:43 [medline]
PHST- 2023/11/13 06:42 [pubmed]
PHST- 2023/11/13 04:28 [entrez]
PHST- 2023/10/26 00:00 [pmc-release]
AID - S2405-8440(23)08426-8 [pii]
AID - e21218 [pii]
AID - 10.1016/j.heliyon.2023.e21218 [doi]
PST - epublish
SO  - Heliyon. 2023 Oct 26;9(11):e21218. doi: 10.1016/j.heliyon.2023.e21218. 
      eCollection 2023 Nov.