PMID- 37954633
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231122
IS  - 2049-9442 (Electronic)
IS  - 2049-9434 (Print)
IS  - 2049-9434 (Linking)
VI  - 19
IP  - 6
DP  - 2023 Dec
TI  - Impact of preoperative type 2 diabetes mellitus on the outcomes of patients with 
      gastric cancer following gastrectomy: Analysis of 834 patients using propensity 
      score matching.
PG  - 97
LID - 10.3892/br.2023.1679 [doi]
LID - 97
AB  - The purpose of the current study was to compare the outcomes of patients with 
      gastric cancer (GC) between the type 2 diabetes mellitus (T2DM) group and the 
      non-T2DM group. The PubMed, Embase and Cochrane Library databases were searched 
      from inception to March 8, 2022, to identify propensity score matching (PSM) 
      studies that analyzed the effect of T2DM on the outcomes of patients with GC. 
      Total complications, overall survival (OS), disease-free survival (DFS) and 
      cancer-specific survival (CSS) were compared between the T2DM group and the 
      non-T2DM group. A total of four PSM studies with 834 patients were included in 
      the current study. There were 311 and 523 patients in the T2DM group and the 
      non-T2DM group, respectively. Baseline characteristics of the two groups were 
      adjusted with PSM in all the four studies, however, no significant difference was 
      found in baseline characteristics (P>0.05). DFS was significantly worse in the 
      T2DM group compared with that in the non-T2DM group [hazard ratio (HR), 1.45; 95% 
      confidence interval (CI), 1.10-1.90; P=0.007)]. However, after pooling up the 
      data, there was no significant difference between the T2DM group and the non-T2DM 
      group in terms of OS (HR, 1.41; 95% CI, 0.92-2.16; P=0.11), CSS (HR, 1.29; 95% 
      CI, 0.92-1.81; P=0.14) and total complications (odds ratio, 1.01; 95% CI, 
      0.64-1.60; P=0.95). Patients with GC and T2DM are associated with poor DFS. 
      However, there were no significant differences between the T2DM group and the 
      non-T2DM group in terms of OS, CSS and total complications.
CI  - Copyright: (c) Peng et al.
FAU - Peng, Dong
AU  - Peng D
AD  - Department of Gastrointestinal Surgery, The First Affiliated Hospital of 
      Chongqing Medical University, Chongqing 400016, P.R. China.
FAU - Xiang, Ying-Chun
AU  - Xiang YC
AD  - Department of Gastrointestinal Surgery, The First Affiliated Hospital of 
      Chongqing Medical University, Chongqing 400016, P.R. China.
FAU - Tang, Kai-Lin
AU  - Tang KL
AD  - Department of Gastrointestinal Surgery, The First Affiliated Hospital of 
      Chongqing Medical University, Chongqing 400016, P.R. China.
FAU - Qiu, Yan-Yu
AU  - Qiu YY
AD  - Department of Gastrointestinal Surgery, The First Affiliated Hospital of 
      Chongqing Medical University, Chongqing 400016, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20231019
PL  - England
TA  - Biomed Rep
JT  - Biomedical reports
JID - 101613227
PMC - PMC10633813
OTO - NOTNLM
OT  - gastric cancer
OT  - outcomes
OT  - propensity score matching
OT  - type 2 diabetes mellitus
COIS- The authors declare that they have no competing interests.
EDAT- 2023/11/13 06:42
MHDA- 2023/11/13 06:43
PMCR- 2023/10/19
CRDT- 2023/11/13 04:35
PHST- 2023/06/29 00:00 [received]
PHST- 2023/09/26 00:00 [accepted]
PHST- 2023/11/13 06:43 [medline]
PHST- 2023/11/13 06:42 [pubmed]
PHST- 2023/11/13 04:35 [entrez]
PHST- 2023/10/19 00:00 [pmc-release]
AID - BR-19-6-01679 [pii]
AID - 10.3892/br.2023.1679 [doi]
PST - epublish
SO  - Biomed Rep. 2023 Oct 19;19(6):97. doi: 10.3892/br.2023.1679. eCollection 2023 
      Dec.