PMID- 37955799
OWN - NLM
STAT- Publisher
LR  - 20231113
IS  - 1179-2027 (Electronic)
IS  - 1170-7690 (Linking)
DP  - 2023 Nov 13
TI  - Comparative Psychometric Performance of Common Generic Paediatric Health-Related 
      Quality of Life Instrument Descriptive Systems: Results from the Australian 
      Paediatric Multi-Instrument Comparison Study.
LID - 10.1007/s40273-023-01330-2 [doi]
AB  - OBJECTIVE: The aim of this study was to compare the psychometric performance of 
      common generic paediatric health-related quality-of-life instrument descriptive 
      systems (PedsQL generic core 4.0, EQ-5D-Y-3L, EQ-5D-Y-5L, Child Health Utility 9D 
      [CHU9D], Assessment of Quality of Life 6D [AQoL-6D], and Health Utilities Index 
      Mark 3 [HUI3]) by child age, report type, and health status. METHODS: Data for 
      children aged 5-18 years were from the Australian Paediatric Multi-Instrument 
      Comparison study. Ceiling effects, test-retest reliability, known-group validity, 
      convergent and divergent validity, and responsiveness were assessed in the total 
      sample and by child age (5-12 years vs 13-18 years), report type (self- vs proxy 
      report), and health status. Instruments were scored using an exploratory level 
      sum score (LSS) approach. RESULTS: Survey data were available for 5945 children, 
      with follow-up data available for 2346 children. The EQ-5D-Y-3L demonstrated 
      ceiling effects. The PedsQL, EQ-5D-Y-3L, EQ-5D-Y-5L, and CHU9D demonstrated 
      acceptable test-retest reliability. All instruments demonstrated known-group, 
      convergent, and divergent validity. The EQ-5D-Y-3L, EQ-5D-Y-5L, and CHU9D 
      demonstrated responsiveness to improvements in health and the PedsQL, EQ-5D-Y-3L, 
      EQ-5D-Y-5L, and CHU9D to worsening health. The AQoL-6D and HUI3 had inconclusive 
      test-retest reliability and responsiveness evidence due to small sample size. 
      Importantly, ceiling effects, test-retest reliability and responsiveness varied 
      by subgroup. CONCLUSION: Results reflect instrument performance using LSSs, which 
      may differ to utility scores. In the total sample, the EQ-5D-Y-5L and CHU9D 
      descriptive systems demonstrated evidence of good performance (i.e., meeting 
      prespecified criteria) across all psychometric attributes tested. Performance 
      varied by child age and report type, indicating room for considerations by 
      population and study.
CI  - (c) 2023. The Author(s).
FAU - Jones, Renee
AU  - Jones R
AUID- ORCID: 0000-0002-5332-5226
AD  - Health Economics Unit, Centre for Health Policy, The University of Melbourne, 
      Melbourne, VIC, Australia. reneej1@student.unimelb.edu.au.
AD  - Health Services and Economics, Murdoch Children's Research Institute, Melbourne, 
      VIC, Australia. reneej1@student.unimelb.edu.au.
FAU - O'Loughlin, Rachel
AU  - O'Loughlin R
AUID- ORCID: 0000-0002-6451-2713
AD  - Health Economics Unit, Centre for Health Policy, The University of Melbourne, 
      Melbourne, VIC, Australia.
AD  - Health Services and Economics, Murdoch Children's Research Institute, Melbourne, 
      VIC, Australia.
AD  - Health Services Research Unit, Royal Children's Hospital, Melbourne, VIC, 
      Australia.
FAU - Xiong, Xiuqin
AU  - Xiong X
AUID- ORCID: 0000-0002-1323-4223
AD  - Health Economics Unit, Centre for Health Policy, The University of Melbourne, 
      Melbourne, VIC, Australia.
FAU - Bahrampour, Mina
AU  - Bahrampour M
AUID- ORCID: 0000-0002-6915-1865
AD  - Centre for Health Economics Research and Evaluation, University of Technology 
      Sydney, Ultimo, NSW, Australia.
FAU - Devlin, Nancy
AU  - Devlin N
AUID- ORCID: 0000-0002-1561-5361
AD  - Health Economics Unit, Centre for Health Policy, The University of Melbourne, 
      Melbourne, VIC, Australia.
FAU - Hiscock, Harriet
AU  - Hiscock H
AUID- ORCID: 0000-0003-3017-2770
AD  - Health Services and Economics, Murdoch Children's Research Institute, Melbourne, 
      VIC, Australia.
AD  - Health Services Research Unit, Royal Children's Hospital, Melbourne, VIC, 
      Australia.
AD  - Department of Paediatrics, The University of Melbourne, Melbourne, VIC, 
      Australia.
FAU - Chen, Gang
AU  - Chen G
AUID- ORCID: 0000-0002-8385-5965
AD  - Centre for Health Economics, Monash Business School, Monash University, 
      Melbourne, VIC, Australia.
FAU - Mulhern, Brendan
AU  - Mulhern B
AUID- ORCID: 0000-0003-3656-8063
AD  - Centre for Health Economics Research and Evaluation, University of Technology 
      Sydney, Ultimo, NSW, Australia.
FAU - Dalziel, Kim
AU  - Dalziel K
AUID- ORCID: 0000-0003-4972-8871
AD  - Health Economics Unit, Centre for Health Policy, The University of Melbourne, 
      Melbourne, VIC, Australia.
AD  - Health Services and Economics, Murdoch Children's Research Institute, Melbourne, 
      VIC, Australia.
CN  - Quality of Life in Kids: Key Evidence to Strengthen Decisions in Australia 
      (QUOKKA) Project Team
LA  - eng
GR  - 1200816/Australian Government Medical Research Futures Fund (MRFF)/
GR  - 361-RA/EuroQol Research Foundation/
GR  - 330-PhD/EuroQol Research Foundation/
GR  - 1136222/National Health and Medical Research Council/
PT  - Journal Article
DEP - 20231113
PL  - New Zealand
TA  - Pharmacoeconomics
JT  - PharmacoEconomics
JID - 9212404
EDAT- 2023/11/13 12:43
MHDA- 2023/11/13 12:43
CRDT- 2023/11/13 11:11
PHST- 2023/10/11 00:00 [accepted]
PHST- 2023/11/13 12:43 [medline]
PHST- 2023/11/13 12:43 [pubmed]
PHST- 2023/11/13 11:11 [entrez]
AID - 10.1007/s40273-023-01330-2 [pii]
AID - 10.1007/s40273-023-01330-2 [doi]
PST - aheadofprint
SO  - Pharmacoeconomics. 2023 Nov 13. doi: 10.1007/s40273-023-01330-2.