PMID- 37956368
OWN - NLM
STAT- MEDLINE
DCOM- 20231115
LR  - 20231122
IS  - 1972-2680 (Electronic)
IS  - 1972-2680 (Linking)
VI  - 17
IP  - 10
DP  - 2023 Oct 31
TI  - PNI, NLR and PLR combined detection prognosis of patients with chronic hepatitis 
      C-associated cirrhosis complicated by T2DM.
PG  - 1356-1361
LID - 10.3855/jidc.18157 [doi]
AB  - INTRODUCTION: The prognostic nutrition index (PNI), neutrophil-to-lymphocyte 
      ratio (NLR), and platelet-to-lymphocyte ratio (PLR) have been studied widely in 
      the context of cancer; however, their correlation with chronic hepatitis 
      C-associated cirrhosis complicated by type 2 diabetes mellitus (T2DM) is unknown. 
      AIM: To investigate the correlation of the PNI, NLR, and PLR with chronic 
      hepatitis C-associated cirrhosis complicated by T2DM. METHODOLOGY: We 
      investigated 226 patients, comprising 56 patients with chronic hepatitis 
      C-associated cirrhosis complicated by T2DM mellitus (group A), 85 patients with 
      chronic hepatitis C-associated cirrhosis (group B), and 85 patients with T2DM 
      (group C). The baseline data of all patients were analyzed. RESULTS: A comparison 
      of baseline data among the three groups showed significant differences in age (p 
      = 0.008). The levels of PNI were different among the three groups (p < 0.01). The 
      NLR, PNI, and PLR were significantly different between the good and poor 
      prognosis groups (p < 0.05). The AUC for the combined determination of PNI, NLR, 
      and PLR, showed excellent diagnostic performance (AUC = 0.911, 95% CI 
      0.741-0.985, sensitivity = 80.00 %, and specificity = 88.89%). CONCLUSIONS: The 
      PNI, NLR, and PLR were closely related to the prognosis of chronic hepatitis 
      C-associated cirrhosis complicated by T2DM, and their combined detection had the 
      highest specificity and sensitivity for the early prediction of the poor 
      prognosis of chronic hepatitis C-associated cirrhosis complicated by T2DM, which 
      has important clinical value.
CI  - Copyright (c) 2023 Dong Wu, Xiaowu Wang; Yunyun Ding, Yan Liu, Tuantuan Li, Yi 
      lang Zhu, Yong Gao, Xiaojuan Wang.
FAU - Wu, Dong
AU  - Wu D
AD  - Department of Pharmacy, Fuyang People's Hospital, Fuyang, Anhui, China.
FAU - Wang, Xiaowu
AU  - Wang X
AD  - Department of Clinical Laboratory, The Second People's Hospital of Fuyang, 
      Fuyang. Fuyang infection Disease Clinical College of Anhui Medical university, 
      Anhui, China.
FAU - Ding, Yunyun
AU  - Ding Y
AD  - Department of Clinical Laboratory, The Second People's Hospital of Fuyang, 
      Fuyang. Fuyang infection Disease Clinical College of Anhui Medical university, 
      Anhui, China.
FAU - Liu, Yan
AU  - Liu Y
AD  - Department of Clinical Laboratory, The Second People's Hospital of Fuyang, 
      Fuyang. Fuyang infection Disease Clinical College of Anhui Medical university, 
      Anhui, China.
FAU - Li, Tuantuan
AU  - Li T
AD  - Department of Clinical Laboratory, The Second People's Hospital of Fuyang, 
      Fuyang. Fuyang infection Disease Clinical College of Anhui Medical university, 
      Anhui, China.
FAU - Zhu, Yi Lang
AU  - Zhu YL
AD  - Department of Clinical Laboratory, The Second People's Hospital of Fuyang, 
      Fuyang. Fuyang infection Disease Clinical College of Anhui Medical university, 
      Anhui, China.
FAU - Gao, Yong
AU  - Gao Y
AD  - Department of Clinical Laboratory, The Second People's Hospital of Fuyang, 
      Fuyang. Fuyang infection Disease Clinical College of Anhui Medical university, 
      Anhui, China.
FAU - Wang, Xiaojuan
AU  - Wang X
AD  - Department of Pharmacy, Fuyang People's Hospital, Fuyang, Anhui, China.
LA  - eng
PT  - Journal Article
DEP - 20231031
PL  - Italy
TA  - J Infect Dev Ctries
JT  - Journal of infection in developing countries
JID - 101305410
SB  - IM
MH  - Humans
MH  - Neutrophils
MH  - Nutrition Assessment
MH  - *Hepatitis C, Chronic/complications
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Prognosis
MH  - Lymphocytes
MH  - Liver Cirrhosis/complications/diagnosis
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Prognostic nutrition index
OT  - T2DM
OT  - chronic hepatitis C-associated cirrhosis
OT  - neutrophil-to-lymphocyte ratio
OT  - platelet-to-lymphocyte ratio
COIS- No Conflict of Interest is declared
EDAT- 2023/11/13 18:41
MHDA- 2023/11/15 06:42
CRDT- 2023/11/13 15:52
PHST- 2023/03/01 00:00 [received]
PHST- 2023/05/07 00:00 [accepted]
PHST- 2023/11/15 06:42 [medline]
PHST- 2023/11/13 18:41 [pubmed]
PHST- 2023/11/13 15:52 [entrez]
AID - 10.3855/jidc.18157 [doi]
PST - epublish
SO  - J Infect Dev Ctries. 2023 Oct 31;17(10):1356-1361. doi: 10.3855/jidc.18157.