PMID- 37958205 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231122 IS - 2075-4418 (Print) IS - 2075-4418 (Electronic) IS - 2075-4418 (Linking) VI - 13 IP - 21 DP - 2023 Oct 25 TI - The Role of Luminal Apposing Metal Stents on the Treatment of Malignant and Benign Gastric Outlet Obstruction. LID - 10.3390/diagnostics13213308 [doi] LID - 3308 AB - Gastric outlet obstruction (GOO) is a clinical syndrome traditionally managed by surgical gastrojejunostomy or enteral stenting. The surgical approach is burdened with a high rate of adverse events (AEs), while enteral stenting has a limited long-term clinical effectiveness, with the need for repeat procedures. The availability of lumen-apposing metal stents (LAMSs) has resulted a shift in the treatment paradigm of GOO. Indeed, endoscopists are now able to create a stable anastomosis between the stomach and small bowel under endosonographic guidance. EUS-guided gastro-enteroanastomosis (EUS-GE) has the theoretical advantage of a durable luminal patency resulting from stent placement away from the site of obstruction, free from surgical-related AEs. This approach could be especially valuable in terminally ill patients with a limited life expectancy. The present paper reviews procedural techniques and clinical outcomes of EUS-GE in the context of both malignant and benign GOOs. FAU - Rimbas, Mihai AU - Rimbas M AD - Gastroenterology Department, Colentina Clinical Hospital, Carol Davila University of Medicine, 020125 Bucharest, Romania. FAU - Lau, Kar Wai AU - Lau KW AUID- ORCID: 0000-0003-4399-7202 AD - Department of Gastroenterology, Royal Stoke University Hospital, Stoke-on-Trent ST4 6QG, UK. FAU - Tripodi, Giulia AU - Tripodi G AD - Digestive Endoscopy Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy. FAU - Rizzatti, Gianenrico AU - Rizzatti G AUID- ORCID: 0000-0003-1876-7587 AD - Digestive Endoscopy Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy. FAU - Larghi, Alberto AU - Larghi A AD - Digestive Endoscopy Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy. LA - eng PT - Journal Article PT - Review DEP - 20231025 PL - Switzerland TA - Diagnostics (Basel) JT - Diagnostics (Basel, Switzerland) JID - 101658402 PMC - PMC10648116 OTO - NOTNLM OT - LAMS OT - duodenal stenting OT - gastric outlet obstruction OT - lumen-apposing metal stents OT - surgical gastrojejunostomy COIS- A.L. has been a consultant for Boston Scientific Corp., Pentax Medical, and M.I. Tech, and has received teaching fees from Taewong Medical and research support from Medtronic. The remaining authors declare no conflict of interest. EDAT- 2023/11/14 06:42 MHDA- 2023/11/14 06:43 PMCR- 2023/10/25 CRDT- 2023/11/14 02:06 PHST- 2023/09/16 00:00 [received] PHST- 2023/10/01 00:00 [revised] PHST- 2023/10/24 00:00 [accepted] PHST- 2023/11/14 06:43 [medline] PHST- 2023/11/14 06:42 [pubmed] PHST- 2023/11/14 02:06 [entrez] PHST- 2023/10/25 00:00 [pmc-release] AID - diagnostics13213308 [pii] AID - diagnostics-13-03308 [pii] AID - 10.3390/diagnostics13213308 [doi] PST - epublish SO - Diagnostics (Basel). 2023 Oct 25;13(21):3308. doi: 10.3390/diagnostics13213308.