PMID- 37958258
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231117
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 13
IP  - 21
DP  - 2023 Nov 1
TI  - Hyperglycaemia and Chronic Obstructive Pulmonary Disease.
LID - 10.3390/diagnostics13213362 [doi]
LID - 3362
AB  - Chronic obstructive pulmonary disease (COPD) may coexist with type 2 diabetes 
      mellitus (T2DM). Patients with COPD have an increased risk of developing T2DM 
      compared with a control but, on the other side, hyperglycaemia and DM have been 
      associated with reduced predicted levels of lung function. The mechanistic 
      relationships between these two diseases are complicated, multifaceted, and 
      little understood, yet they can impact treatment strategy. The potential risks 
      and benefits for patients with T2DM treated with pulmonary drugs and the 
      potential pulmonary risks and benefits for patients with COPD when taking 
      antidiabetic drugs should always be considered. The interaction between the 
      presence and/or treatment of COPD, risk of infection, presence and/or treatment 
      of T2DM and risk of acute exacerbations of COPD (AECOPDs) can be represented as a 
      vicious circle; however, several strategies may help to break this circle. The 
      most effective approach to simultaneously treating T2DM and COPD is to interfere 
      with the shared inflammatory substrate, thus targeting both lung inflammation 
      (COPD) and vascular inflammation (DM). In any case, it is always crucial to 
      establish glycaemic management since the reduction in lung function found in 
      people with diabetes might decrease the threshold for clinical manifestations of 
      COPD. In this article, we examine possible connections between COPD and T2DM as 
      well as pharmacological strategies that could focus on these connections.
FAU - Cazzola, Mario
AU  - Cazzola M
AUID- ORCID: 0000-0003-4895-9707
AD  - Unit of Respiratory Medicine, Department of Experimental Medicine, University of 
      Rome 'Tor Vergata', 00133 Rome, Italy.
FAU - Rogliani, Paola
AU  - Rogliani P
AUID- ORCID: 0000-0001-7801-5040
AD  - Unit of Respiratory Medicine, Department of Experimental Medicine, University of 
      Rome 'Tor Vergata', 00133 Rome, Italy.
AD  - Division of Respiratory Medicine, University Hospital Fondazione Policlinico Tor 
      Vergata, 00133 Rome, Italy.
FAU - Ora, Josuel
AU  - Ora J
AUID- ORCID: 0000-0001-9877-7851
AD  - Division of Respiratory Medicine, University Hospital Fondazione Policlinico Tor 
      Vergata, 00133 Rome, Italy.
FAU - Calzetta, Luigino
AU  - Calzetta L
AUID- ORCID: 0000-0003-0456-069X
AD  - Unit of Respiratory Disease and Lung Function, Department of Medicine and 
      Surgery, University of Parma, 43121 Parma, Italy.
FAU - Lauro, Davide
AU  - Lauro D
AUID- ORCID: 0000-0002-8597-4415
AD  - Unit of Endocrinology and Metabolic Diseases, Department of Systems Medicine, 
      University of Rome 'Tor Vergata', 00173 Rome, Italy.
AD  - Division of Endocrinology and Diabetes, University Hospital Fondazione 
      Policlinico Tor Vergata, 00133 Rome, Italy.
FAU - Matera, Maria Gabriella
AU  - Matera MG
AD  - Unit of Pharmacology, Department of Experimental Medicine, University of Campania 
      'Luigi Vanvitelli', 81138 Naples, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231101
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC10650064
OTO - NOTNLM
OT  - chronic obstructive pulmonary disease
OT  - hyperglycaemia
OT  - lung function
OT  - pharmacological interferences
OT  - systemic inflammation
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2023/11/14 06:42
MHDA- 2023/11/14 06:43
PMCR- 2023/11/01
CRDT- 2023/11/14 02:06
PHST- 2023/09/25 00:00 [received]
PHST- 2023/10/20 00:00 [revised]
PHST- 2023/10/30 00:00 [accepted]
PHST- 2023/11/14 06:43 [medline]
PHST- 2023/11/14 06:42 [pubmed]
PHST- 2023/11/14 02:06 [entrez]
PHST- 2023/11/01 00:00 [pmc-release]
AID - diagnostics13213362 [pii]
AID - diagnostics-13-03362 [pii]
AID - 10.3390/diagnostics13213362 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2023 Nov 1;13(21):3362. doi: 10.3390/diagnostics13213362.