PMID- 37958564
OWN - NLM
STAT- MEDLINE
DCOM- 20231115
LR  - 20231122
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 21
DP  - 2023 Oct 25
TI  - Immune Diseases Associated with Aging: Molecular Mechanisms and Treatment 
      Strategies.
LID - 10.3390/ijms242115584 [doi]
LID - 15584
AB  - Aging is associated with a decline in immune function, thereby causing an 
      increased susceptibility to various diseases. Herein, we review immune diseases 
      associated with aging, focusing on tumors, atherosclerosis, and immunodeficiency 
      disorders. The molecular mechanisms underlying these conditions are discussed, 
      highlighting telomere shortening, tissue inflammation, and altered signaling 
      pathways, e.g., the mammalian target of the rapamycin (mTOR) pathway, as key 
      contributors to immune dysfunction. The role of the senescence-associated 
      secretory phenotype in driving chronic tissue inflammation and disruption has 
      been examined. Our review underscores the significance of targeting tissue 
      inflammation and immunomodulation for treating immune disorders. In addition, 
      anti-inflammatory medications, including corticosteroids and nonsteroidal 
      anti-inflammatory drugs, and novel approaches, e.g., probiotics and polyphenols, 
      are discussed. Immunotherapy, particularly immune checkpoint inhibitor therapy 
      and adoptive T-cell therapy, has been explored for its potential to enhance 
      immune responses in older populations. A comprehensive analysis of immune 
      disorders associated with aging and underlying molecular mechanisms provides 
      insights into potential treatment strategies to alleviate the burden of these 
      conditions in the aging population. The interplay among immune dysfunction, 
      chronic tissue inflammation, and innovative therapeutic approaches highlights the 
      importance of elucidating these complex processes to develop effective 
      interventions to improve the quality of life in older adults.
FAU - Kim, Mi Eun
AU  - Kim ME
AD  - Department of Biological Science, Immunology Research Lab & BK21-Four Educational 
      Research Group for Age-Associated Disorder Control Technology, Chosun University, 
      Gwangju 61452, Republic of Korea.
FAU - Lee, Jun Sik
AU  - Lee JS
AUID- ORCID: 0000-0003-1051-581X
AD  - Department of Biological Science, Immunology Research Lab & BK21-Four Educational 
      Research Group for Age-Associated Disorder Control Technology, Chosun University, 
      Gwangju 61452, Republic of Korea.
LA  - eng
GR  - 2020/Chosun University/
PT  - Journal Article
PT  - Review
DEP - 20231025
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Anti-Inflammatory Agents)
SB  - IM
MH  - Humans
MH  - Aged
MH  - *Immunosenescence
MH  - Quality of Life
MH  - Aging
MH  - *Immune System Diseases
MH  - Inflammation/therapy
MH  - Anti-Inflammatory Agents
PMC - PMC10647753
OTO - NOTNLM
OT  - aging
OT  - immune diseases
OT  - immunosenescence
OT  - molecular therapies
COIS- The authors declare no conflict of interest.
EDAT- 2023/11/14 06:43
MHDA- 2023/11/15 06:42
PMCR- 2023/10/25
CRDT- 2023/11/14 02:08
PHST- 2023/09/19 00:00 [received]
PHST- 2023/10/19 00:00 [revised]
PHST- 2023/10/24 00:00 [accepted]
PHST- 2023/11/15 06:42 [medline]
PHST- 2023/11/14 06:43 [pubmed]
PHST- 2023/11/14 02:08 [entrez]
PHST- 2023/10/25 00:00 [pmc-release]
AID - ijms242115584 [pii]
AID - ijms-24-15584 [pii]
AID - 10.3390/ijms242115584 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Oct 25;24(21):15584. doi: 10.3390/ijms242115584.