PMID- 37960276 OWN - NLM STAT- MEDLINE DCOM- 20231115 LR - 20231122 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 15 IP - 21 DP - 2023 Oct 31 TI - Nurturing through Nutrition: Exploring the Role of Antioxidants in Maternal Diet during Pregnancy to Mitigate Developmental Programming of Chronic Diseases. LID - 10.3390/nu15214623 [doi] LID - 4623 AB - Chronic diseases represent one of the major causes of death worldwide. It has been suggested that pregnancy-related conditions, such as gestational diabetes mellitus (GDM), maternal obesity (MO), and intra-uterine growth restriction (IUGR) induce an adverse intrauterine environment, increasing the offspring's predisposition to chronic diseases later in life. Research has suggested that mitochondrial function and oxidative stress may play a role in the developmental programming of chronic diseases. Having this in mind, in this review, we include evidence that mitochondrial dysfunction and oxidative stress are mechanisms by which GDM, MO, and IUGR program the offspring to chronic diseases. In this specific context, we explore the promising advantages of maternal antioxidant supplementation using compounds such as resveratrol, curcumin, N-acetylcysteine (NAC), and Mitoquinone (MitoQ) in addressing the metabolic dysfunction and oxidative stress associated with GDM, MO, and IUGR in fetoplacental and offspring metabolic health. This approach holds potential to mitigate developmental programming-related risk of chronic diseases, serving as a probable intervention for disease prevention. FAU - Diniz, Mariana S AU - Diniz MS AUID- ORCID: 0000-0002-2161-9676 AD - CNC-UC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal. AD - CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-517 Coimbra, Portugal. AD - Doctoral Programme in Experimental Biology and Biomedicine (PDBEB), Institute for Interdisciplinary Research, University of Coimbra, 3004-504 Coimbra, Portugal. FAU - Magalhaes, Carina C AU - Magalhaes CC AD - CNC-UC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal. AD - CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-517 Coimbra, Portugal. FAU - Tocantins, Carolina AU - Tocantins C AUID- ORCID: 0000-0002-3758-0454 AD - CNC-UC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal. AD - CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-517 Coimbra, Portugal. AD - Doctoral Programme in Experimental Biology and Biomedicine (PDBEB), Institute for Interdisciplinary Research, University of Coimbra, 3004-504 Coimbra, Portugal. FAU - Grilo, Luis F AU - Grilo LF AUID- ORCID: 0000-0002-6278-9241 AD - CNC-UC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal. AD - CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-517 Coimbra, Portugal. AD - Doctoral Programme in Experimental Biology and Biomedicine (PDBEB), Institute for Interdisciplinary Research, University of Coimbra, 3004-504 Coimbra, Portugal. FAU - Teixeira, Jose AU - Teixeira J AUID- ORCID: 0000-0003-0834-5698 AD - CNC-UC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal. AD - CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-517 Coimbra, Portugal. FAU - Pereira, Susana P AU - Pereira SP AUID- ORCID: 0000-0002-1168-2444 AD - CNC-UC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal. AD - CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-517 Coimbra, Portugal. AD - Laboratory of Metabolism and Exercise (LaMetEx), Research Centre in Physical Activity, Health and Leisure (CIAFEL), Laboratory for Integrative and Translational Research in Population Health (ITR), Faculty of Sports, University of Porto, 4200-450 Porto, Portugal. LA - eng GR - SFRH/BPD/116061/2016; SFRH/BD/11934/2022; SFRH/BD/11924/2022; SFRH/BD/5539/2020/ERDF funds through the Operational Programme for Competitiveness/ GR - HORIZON-HLTH-2022-STAYHLTH-101080329-2; PTDC/DTP-DES/1082/2014 (POCI-01-0145-FEDER-016657), CENTRO-01-0246-FEDER- 000010 (Multidisciplinary Institute of Ageing in Coimbra), strategic projects UIDB/04539/2020, UIDP/04539/2020, LA/P/0058/2020/ERDF funds through the Operational Programme for Competitiveness-COMPETE 2020/ PT - Journal Article PT - Review DEP - 20231031 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Antioxidants) RN - Q369O8926L (Resveratrol) SB - IM MH - Pregnancy MH - Female MH - Humans MH - Antioxidants/pharmacology MH - *Prenatal Exposure Delayed Effects/prevention & control/etiology MH - Resveratrol/pharmacology MH - *Diabetes, Gestational/prevention & control MH - *Pregnancy Complications/prevention & control MH - Diet MH - *Obesity, Maternal/complications MH - Fetal Growth Retardation/prevention & control MH - Chronic Disease PMC - PMC10649237 OTO - NOTNLM OT - chronic diseases OT - developmental programming OT - disease prevention OT - maternal antioxidant supplementation OT - metabolic dysfunction OT - oxidative stress COIS- The authors state there is no conflict of interest. EDAT- 2023/11/14 06:43 MHDA- 2023/11/15 06:43 PMCR- 2023/10/31 CRDT- 2023/11/14 02:18 PHST- 2023/09/16 00:00 [received] PHST- 2023/10/27 00:00 [revised] PHST- 2023/10/27 00:00 [accepted] PHST- 2023/11/15 06:43 [medline] PHST- 2023/11/14 06:43 [pubmed] PHST- 2023/11/14 02:18 [entrez] PHST- 2023/10/31 00:00 [pmc-release] AID - nu15214623 [pii] AID - nutrients-15-04623 [pii] AID - 10.3390/nu15214623 [doi] PST - epublish SO - Nutrients. 2023 Oct 31;15(21):4623. doi: 10.3390/nu15214623.