PMID- 37960772
OWN - NLM
STAT- MEDLINE
DCOM- 20231115
LR  - 20240312
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 102
IP  - 45
DP  - 2023 Nov 10
TI  - The effect of sedentary time on cardiovascular disease risk in middle-aged and 
      elderly patients with type 2 diabetes mellitus.
PG  - e35901
LID - 10.1097/MD.0000000000035901 [doi]
LID - e35901
AB  - Sedentary lifestyle has become quite prevalent lately, and it has been associated 
      with cardiovascular diseases (CVDs). CVD is a primary cause of premature death in 
      patients with type 2 diabetes mellitus (T2DM). Some studies have focused on the 
      association between sedentary behavior and blood glucose among T2DM patients. 
      However, the occurrence and development of CVD involves many factors, such as 
      blood glucose, blood lipid and so on. Therefore, we comprehensively examined the 
      association of sedentary time with overall CVD risk and various metabolic risk 
      factors in T2DM patients. A total of 775 middle-aged and elderly patients with 
      T2DM were assessed. Framingham risk equation was employed to assess their overall 
      CVD risk, while the sedentary time was self-reported. Demographic data and 
      anthropometric and cardiac metabolic indicators were separately analyzed for both 
      genders. The median age of the respondents was 55 (range: 45-75) years, and 
      39.23% were women. The overall risk of CVD in women was lower than that in men. 
      Linear regression analysis revealed that sedentary time was significantly 
      positively correlated with overall CVD risk and triglyceride level, but not with 
      diastolic blood pressure and glycosylated hemoglobin and high-density lipoprotein 
      cholesterol (HDL-C) levels. However, the correlation of sedentary time with 
      fasting blood glucose level, body mass index, total cholesterol, and low-density 
      lipoprotein cholesterol was only detected in women. In middle-aged and elderly 
      patients with T2DM, prolonged sedentary time may increase the triglyceride levels 
      and the overall risk of CVD. The adverse effects of sedentary time on fasting 
      blood glucose, body mass index, total cholesterol, and low-density lipoprotein 
      cholesterol may exhibit sex-based differences, as they were detected only in 
      women.
CI  - Copyright (c) 2023 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Jia, Wei
AU  - Jia W
AUID- ORCID: 0009-0000-5216-1875
AD  - Department of Endocrinology and Metabolism, The Affiliated Changzhou No. 2 
      People's Hospital of Nanjing Medical University, Changzhou, Jiangsu Province, 
      China.
FAU - He, Wenxia
AU  - He W
FAU - Cui, Qian
AU  - Cui Q
FAU - Ye, Xinhua
AU  - Ye X
FAU - Qian, Hui
AU  - Qian H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Triglycerides)
RN  - 0 (Cholesterol, HDL)
SB  - IM
MH  - Middle Aged
MH  - Aged
MH  - Humans
MH  - Female
MH  - Male
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Sedentary Behavior
MH  - *Cardiovascular Diseases/epidemiology/etiology
MH  - Blood Glucose/metabolism
MH  - Risk Factors
MH  - Cholesterol, LDL
MH  - Triglycerides
MH  - Cholesterol, HDL
PMC - PMC10637485
COIS- The authors have no funding and conflicts of interest to disclose.
EDAT- 2023/11/14 06:42
MHDA- 2023/11/15 06:42
PMCR- 2023/11/10
CRDT- 2023/11/14 02:26
PHST- 2023/11/15 06:42 [medline]
PHST- 2023/11/14 06:42 [pubmed]
PHST- 2023/11/14 02:26 [entrez]
PHST- 2023/11/10 00:00 [pmc-release]
AID - 00005792-202311100-00059 [pii]
AID - 10.1097/MD.0000000000035901 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2023 Nov 10;102(45):e35901. doi: 
      10.1097/MD.0000000000035901.