PMID- 37961994
OWN - NLM
STAT- MEDLINE
DCOM- 20240214
LR  - 20240214
IS  - 1753-0407 (Electronic)
IS  - 1753-0393 (Print)
IS  - 1753-0407 (Linking)
VI  - 16
IP  - 2
DP  - 2024 Feb
TI  - Association of remnant cholesterol and newly diagnosed early-onset type 2 
      diabetes mellitus in Chinese population: A retrospective cross-sectional study.
PG  - e13498
LID - 10.1111/1753-0407.13498 [doi]
LID - e13498
AB  - BACKGROUND: With the increasing incidence of diabetes worldwide, patients 
      diagnosed with diabetes has been getting younger. Previous studies have shown 
      that high remnant cholesterol (RC) level leads to an increased risk of 
      cardiovascular disease events. However, the relationship between RC levels and 
      newly diagnosed early-onset type 2 diabetes mellitus (T2DM) is unknown. This 
      study aimed to explore the association between RC and newly diagnosed early-onset 
      T2DM. METHODS: A total of 606 patients newly diagnosed with early-onset T2DM and 
      619 gender-matched subjects with normal blood glucose levels were retrospectively 
      enrolled in this study. All T2DM patients showed onset age of 18-40 years. Binary 
      logistic regression analysis was performed to analyze independent risk factors 
      and receiver operating characteristic (ROC) analysis was used to explore the 
      predictive value of RC and other unconventional lipids. Moreover, the correlation 
      between RC and insulin resistance in patients with newly diagnosed early-onset 
      T2DM was also examined with binary logistic regression analysis and Spearman 
      correlation analysis. RESULTS: Increased RC level was an independent risk factor 
      for early-onset T2DM (p < .05). The area under the curve on ROC analysis of RC 
      was 0.805, 95% confidence interval (CI) was 0.781 ~ 0.826, sensitivity was 82.18% 
      and specificity was 66.24%, which showed higher predictive value than those of 
      triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio and total 
      cholesterol (TC)/HDL-C ratio. Cutoff value of RC was 0.32 mmol/L. Level of RC in 
      early-onset T2DM patients with moderate or severe insulin resistance was 
      significantly higher than that in patients with mild insulin resistance 
      (p < .0001). No difference in RC levels was found between patients with moderate 
      and severe insulin resistance (p > .05). RC was still correlated with insulin 
      resistance after adjusting the conventional lipid parameters (TG, TC, HDL-C, and 
      low-density lipoprotein cholesterol) using partial correlation analysis. 
      CONCLUSION: RC level was higher in patients with early-onset T2DM and was 
      correlated to the degree of insulin resistance as well. Patients aged 18-40 years 
      with RC >0.32 mmol/L showed an increased risk of developing T2DM.
CI  - (c) 2023 The Authors. Journal of Diabetes published by Ruijin Hospital, Shanghai 
      Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.
FAU - Dong, Wenjing
AU  - Dong W
AD  - Chinese PLA Medical College, Beijing, China.
AD  - Department of Endocrinology, The First Medical Center of Chinese PLA General 
      Hospital, Beijing, China.
AD  - Department of Gerontology, Hainan Hospital of Chinese PLA General Hospital, 
      Sanya, China.
FAU - Yan, Shiju
AU  - Yan S
AD  - Department of Orthopedics, Hainan Hospital of Chinese PLA General Hospital, 
      Sanya, China.
FAU - Chen, Han
AU  - Chen H
AD  - Department of Information, Hainan Hospital of Chinese PLA General Hospital, 
      Sanya, China.
FAU - Zhao, Jian
AU  - Zhao J
AD  - Chinese PLA Medical College, Beijing, China.
AD  - Department of Endocrinology, The First Medical Center of Chinese PLA General 
      Hospital, Beijing, China.
FAU - Zhang, Zengqiang
AU  - Zhang Z
AD  - Department of Gerontology, Hainan Hospital of Chinese PLA General Hospital, 
      Sanya, China.
FAU - Gu, Weijun
AU  - Gu W
AUID- ORCID: 0000-0001-8690-645X
AD  - Department of Endocrinology, The First Medical Center of Chinese PLA General 
      Hospital, Beijing, China.
LA  - eng
GR  - Hainan Province Clinical Medical Center/
PT  - Journal Article
DEP - 20231114
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
RN  - 97C5T2UQ7J (Cholesterol)
RN  - 0 (Triglycerides)
RN  - 0 (Cholesterol, HDL)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/diagnosis/epidemiology
MH  - Retrospective Studies
MH  - Cross-Sectional Studies
MH  - *Insulin Resistance
MH  - Cholesterol
MH  - Triglycerides
MH  - Cholesterol, HDL
MH  - China/epidemiology
PMC - PMC10859310
OTO - NOTNLM
OT  - dyslipidemia
OT  - early-onset type 2 diabetes mellitus
OT  - insulin resistance
OT  - remnant cholesterol
OT  - risk factor
EDAT- 2023/11/14 12:42
MHDA- 2024/02/12 05:43
PMCR- 2023/11/14
CRDT- 2023/11/14 06:33
PHST- 2023/09/18 00:00 [revised]
PHST- 2023/07/02 00:00 [received]
PHST- 2023/10/24 00:00 [accepted]
PHST- 2024/02/12 05:43 [medline]
PHST- 2023/11/14 12:42 [pubmed]
PHST- 2023/11/14 06:33 [entrez]
PHST- 2023/11/14 00:00 [pmc-release]
AID - JDB13498 [pii]
AID - 10.1111/1753-0407.13498 [doi]
PST - ppublish
SO  - J Diabetes. 2024 Feb;16(2):e13498. doi: 10.1111/1753-0407.13498. Epub 2023 Nov 
      14.