PMID- 37962394
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20231216
IS  - 2165-0497 (Electronic)
IS  - 2165-0497 (Linking)
VI  - 11
IP  - 6
DP  - 2023 Dec 12
TI  - Honduras HIV cohort: HLA class I and CCR5-Delta32 profiles and their associations 
      with HIV disease outcome.
PG  - e0161323
LID - 10.1128/spectrum.01613-23 [doi]
LID - e01613-23
AB  - We identify both canonical and novel human leukocyte antigen (HLA)-HIV 
      associations, providing a first step toward improved understanding of HIV immune 
      control among the understudied Honduras Mestizo population. Our results are 
      relevant to understanding the protective or detrimental effects of HLA subtypes 
      in Latin America because their unique HLA diversity poses challenges for 
      designing vaccines against HIV and interpreting results from such vaccine trials. 
      Likewise, the description of the HLA profile in an understudied population that 
      shows a unique HLA immunogenetic background is not only relevant for HIV 
      immunology but also relevant in population genetics, molecular anthropology, 
      susceptibility to other infections, autoimmune diseases, and allograft 
      transplantation.
FAU - Valenzuela-Ponce, Humberto
AU  - Valenzuela-Ponce H
AUID- ORCID: 0000-0003-0350-2391
AD  - CIENI Centro de Investigacion en Enfermedades Respiratorias, Instituto Nacional 
      de Enfermedades Respiratorias Ismael Cosio Villegas , Mexico City, Mexico.
FAU - Carbajal, Candy
AU  - Carbajal C
AD  - Universidad Nacional Autonoma de Honduras , Tegucigalpa, Honduras.
FAU - Soto-Nava, Maribel
AU  - Soto-Nava M
AD  - CIENI Centro de Investigacion en Enfermedades Respiratorias, Instituto Nacional 
      de Enfermedades Respiratorias Ismael Cosio Villegas , Mexico City, Mexico.
FAU - Tapia-Trejo, Daniela
AU  - Tapia-Trejo D
AD  - CIENI Centro de Investigacion en Enfermedades Respiratorias, Instituto Nacional 
      de Enfermedades Respiratorias Ismael Cosio Villegas , Mexico City, Mexico.
FAU - Garcia-Morales, Claudia
AU  - Garcia-Morales C
AD  - CIENI Centro de Investigacion en Enfermedades Respiratorias, Instituto Nacional 
      de Enfermedades Respiratorias Ismael Cosio Villegas , Mexico City, Mexico.
FAU - Murillo, Wendy
AU  - Murillo W
AD  - Universidad Nacional Autonoma de Honduras , Tegucigalpa, Honduras.
FAU - Lorenzana, Ivette
AU  - Lorenzana I
AD  - Universidad Nacional Autonoma de Honduras , Tegucigalpa, Honduras.
FAU - Reyes-Teran, Gustavo
AU  - Reyes-Teran G
AD  - Comision Coordinadora de Institutos Nacional de Salud y Hospitales de Alta 
      Especialidad, Secretar ́ia de Salud , Mexico City, Mexico.
FAU - Avila-Rios, Santiago
AU  - Avila-Rios S
AUID- ORCID: 0000-0003-3371-4248
AD  - CIENI Centro de Investigacion en Enfermedades Respiratorias, Instituto Nacional 
      de Enfermedades Respiratorias Ismael Cosio Villegas , Mexico City, Mexico.
LA  - eng
GR  - CONACyT-PRONAII Virologia 303079/Consejo Nacional de Ciencia y Tecnologia 
      (CONACYT)/
GR  - CONACyT-CF-2019-2558583/Consejo Nacional de Ciencia y Tecnologia (CONACYT)/
GR  - PJT-148621 ,PJT-159625/Gouvernement du Canada | Canadian Institutes of Health 
      Research (IRSC)/
GR  - Programa Presupuestal P016 Anexo 13 del Decreto del Presupuesto de Egresos de la 
      Federacion/Mexican Government/
PT  - Journal Article
DEP - 20231114
PL  - United States
TA  - Microbiol Spectr
JT  - Microbiology spectrum
JID - 101634614
RN  - 0 (HLA Antigens)
RN  - 0 (CCR5 protein, human)
RN  - 0 (Receptors, CCR5)
SB  - IM
MH  - Humans
MH  - Gene Frequency
MH  - Honduras
MH  - *HIV-1/genetics
MH  - *HIV Infections
MH  - Genetics, Population
MH  - HLA Antigens/genetics
MH  - Alleles
MH  - Receptors, CCR5/genetics
PMC - PMC10714756
OTO - NOTNLM
OT  - HIV disease outcome
OT  - HLA allele frequencies
OT  - HLA haplotype structures
OT  - HLA linkage disequilibrium
OT  - HLA-HIV disease associations
OT  - Honduran Mestizos
OT  - Latin America
OT  - Mesoamerican Mestizos
COIS- The authors declare no conflict of interest.
EDAT- 2023/11/14 12:43
MHDA- 2023/12/17 13:19
PMCR- 2023/11/14
CRDT- 2023/11/14 09:13
PHST- 2023/12/17 13:19 [medline]
PHST- 2023/11/14 12:43 [pubmed]
PHST- 2023/11/14 09:13 [entrez]
PHST- 2023/11/14 00:00 [pmc-release]
AID - 01613-23 [pii]
AID - spectrum.01613-23 [pii]
AID - 10.1128/spectrum.01613-23 [doi]
PST - ppublish
SO  - Microbiol Spectr. 2023 Dec 12;11(6):e0161323. doi: 10.1128/spectrum.01613-23. 
      Epub 2023 Nov 14.