PMID- 37964074
OWN - NLM
STAT- MEDLINE
DCOM- 20240325
LR  - 20240325
IS  - 1933-7205 (Electronic)
IS  - 1933-7191 (Linking)
VI  - 31
IP  - 4
DP  - 2024 Apr
TI  - Association of Trophectoderm mRNAs and MicroRNAs with Chromosomal Aneuploidy of 
      Embryo.
PG  - 1028-1033
LID - 10.1007/s43032-023-01381-y [doi]
AB  - MicroRNAs (miRNAs) and mRNAs can serve as indicators of the chromosomal state of 
      an embryo, with different profiles observed in euploid and aneuploid blastocysts. 
      Examining the levels of miRNAs associated with aneuploidy and euploidy, as well 
      as mRNAs related to implantation, can aid in predicting blastocyst chromosomal 
      normality and improving assisted reproductive technology (ART) outcomes. This 
      study analyzed chromosomal abnormality of 25 blastocysts using fluorescence in 
      situ hybridization (FISH) and also the expression of genes ERBB4, SELL, ITGB3, 
      and ITGAV, as well as miRNAs, miR-339, miR-27b, miR-661, miR-30c, miR-191, 
      miR-345, miR-142, miR-141, miR-20a, and miR-372. We found that 17 out of 25 
      embryos were aneuploid. Moreover, results revealed lower expression levels of 
      miR-30c and miR-372 in aneuploid embryos compared to euploid ones, while ITGAV 
      and ITGB3 showed significantly higher expression in aneuploid embryos. These 
      findings suggest that miR-372, miR-30c, ITGAV, and ITGB3 expression in 
      trophectoderm cells can serve as biomarkers for assessing embryo health.
CI  - (c) 2023. The Author(s), under exclusive licence to Society for Reproductive 
      Investigation.
FAU - Esmaeilivand, Masoumeh
AU  - Esmaeilivand M
AD  - Department of Obstetrics and Gynecology, School of Medicine, Kermanshah 
      University of Medical Science, Kermanshah, Iran.
AD  - Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Ghasemzadeh, Aliyeh
AU  - Ghasemzadeh A
AD  - Women's Reproductive Health Research Center, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Niknafs, Behrooz
AU  - Niknafs B
AD  - Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 
      niknafsbeh@yahoo.com.
AD  - Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of 
      Medical Science, Tabriz, Iran. niknafsbeh@yahoo.com.
AD  - Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran. niknafsbeh@yahoo.com.
FAU - Fattahi, Amir
AU  - Fattahi A
AUID- ORCID: 0000-0002-7391-276X
AD  - Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 
      amirfattahi@gmail.com.
AD  - Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran. amirfattahi@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20231114
PL  - United States
TA  - Reprod Sci
JT  - Reproductive sciences (Thousand Oaks, Calif.)
JID - 101291249
RN  - 0 (MicroRNAs)
RN  - 0 (MIRN661 microRNA, human)
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - *MicroRNAs/genetics/metabolism
MH  - In Situ Hybridization, Fluorescence
MH  - *Preimplantation Diagnosis/methods
MH  - Embryo Implantation/genetics
MH  - Aneuploidy
MH  - Blastocyst/metabolism
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Aneuploid
OT  - Biomarker
OT  - Euploid
OT  - Implantation
OT  - miRNAs
EDAT- 2023/11/15 00:41
MHDA- 2024/03/25 06:42
CRDT- 2023/11/14 23:40
PHST- 2023/07/24 00:00 [received]
PHST- 2023/10/12 00:00 [accepted]
PHST- 2024/03/25 06:42 [medline]
PHST- 2023/11/15 00:41 [pubmed]
PHST- 2023/11/14 23:40 [entrez]
AID - 10.1007/s43032-023-01381-y [pii]
AID - 10.1007/s43032-023-01381-y [doi]
PST - ppublish
SO  - Reprod Sci. 2024 Apr;31(4):1028-1033. doi: 10.1007/s43032-023-01381-y. Epub 2023 
      Nov 14.