PMID- 37964148 OWN - NLM STAT- MEDLINE DCOM- 20231218 LR - 20231227 IS - 1614-7499 (Electronic) IS - 0944-1344 (Linking) VI - 30 IP - 58 DP - 2023 Dec TI - Associations between maternal serum phytoestrogens and liver function markers: a cross-sectional study from China. PG - 122038-122050 LID - 10.1007/s11356-023-30761-9 [doi] AB - Phytoestrogens (PEs) may harm liver function. However, studies in pregnant women are limited. Our study was conducted in pregnant women to assess the effect of serum PEs on liver function markers. We conducted a cross-sectional study focusing in the first trimester of pregnancy. A total of 352 pregnant women were enrolled in the study. We used generalized linear model (GLM) to explore the associations between each PE and each marker of liver function. We used Quantile g-computation (Qgcomp) and Bayesian kernel machine regression (BKMR) models to explore the associations between mixed exposure to all PEs and liver function markers. The GLM results showed that equol (EQU), daidzein (DAD), genistein (GEN), enterolactone (ENT), and enterodiol (END) were negatively correlated with albumin (ALB). DAD and GEN were associated with elevated alanine aminotransferase (ALT). DAD, GEN, naringin (NAR), and glycitein (GLY) were related to elevated aspartate aminotransferase (AST). Mixed exposure model results showed that the mixture of PEs was associated with reduced ALB. Our results support the existence of associations between PEs and maternal liver function in the first trimester. Emphasizing the detrimental associations between serum PEs and liver function in pregnant women is essential to ensure maternal liver health during pregnancy. CI - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Wang, Xiaogang AU - Wang X AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, China. FAU - Lei, Lei AU - Lei L AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, China. FAU - Wang, Lijun AU - Wang L AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, China. FAU - Huang, Dandan AU - Huang D AD - Nanning Wuming District Maternal and Child Health Care Hospital, Nanning, 530100, Guangxi, China. FAU - Huang, Jianchun AU - Huang J AD - Department of Obstetrics, The Third Affiliated Hospital of Guangxi Medical University, Nanning, 530031, Guangxi, China. FAU - Guo, Erna AU - Guo E AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, China. FAU - Li, Jinxiu AU - Li J AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, China. FAU - Huang, Weiyan AU - Huang W AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, China. FAU - Zhou, Lihong AU - Zhou L AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, China. FAU - Deng, Jiatong AU - Deng J AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, China. FAU - Chen, Wanling AU - Chen W AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, China. FAU - Li, Chanhua AU - Li C AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, China. FAU - Qiu, Xiaoqiang AU - Qiu X AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, China. FAU - Huang, Dongping AU - Huang D AD - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Liu, Shun AU - Liu S AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Zeng, Xiaoyun AU - Zeng X AUID- ORCID: 0000-0003-0671-2597 AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, China. zengxiaoyun@gxmu.edu.cn. LA - eng GR - 81460517/National Natural Science Foundation of China/ GR - 81860587/National Natural Science Foundation of China/ GR - AB17195012/Guangxi Key Research Program/ GR - 2021KY0102/Research basic ability improvement project for young and middle-aged teachers in universities in Guangxi/ PT - Journal Article DEP - 20231115 PL - Germany TA - Environ Sci Pollut Res Int JT - Environmental science and pollution research international JID - 9441769 RN - 0 (Phytoestrogens) RN - DH2M523P0H (Genistein) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Phytoestrogens MH - Cross-Sectional Studies MH - Bayes Theorem MH - *Genistein MH - Liver MH - China OTO - NOTNLM OT - Harm OT - Liver function OT - Mixed exposure methods OT - Phytoestrogens OT - Pregnant women OT - Serum EDAT- 2023/11/15 00:41 MHDA- 2023/12/18 06:41 CRDT- 2023/11/14 23:44 PHST- 2023/08/30 00:00 [received] PHST- 2023/10/26 00:00 [accepted] PHST- 2023/12/18 06:41 [medline] PHST- 2023/11/15 00:41 [pubmed] PHST- 2023/11/14 23:44 [entrez] AID - 10.1007/s11356-023-30761-9 [pii] AID - 10.1007/s11356-023-30761-9 [doi] PST - ppublish SO - Environ Sci Pollut Res Int. 2023 Dec;30(58):122038-122050. doi: 10.1007/s11356-023-30761-9. Epub 2023 Nov 15.