PMID- 37964347
OWN - NLM
STAT- MEDLINE
DCOM- 20231116
LR  - 20240102
IS  - 1746-1596 (Electronic)
IS  - 1746-1596 (Linking)
VI  - 18
IP  - 1
DP  - 2023 Nov 14
TI  - Detection of HHV-6 Virus in specimen of a ductal pancreatic adenocarcinoma with 
      comparison in tumor and normal tissue.
PG  - 124
LID - 10.1186/s13000-023-01402-z [doi]
LID - 124
AB  - AIMS: The association of human herpesvirus 6 (HHV-6) species with pancreatic 
      cancer is controversially discussed. The aim of this study was to further 
      investigate the postulated association and to identify the basis of HHV-6 DNA 
      positivity reported for pancreatic cancer tissue. METHODS: All samples of 
      patients with pancreatic cancer (cancer and surrounding tissue) were analyzed for 
      presence of HHV-6 DNA by PCR and then selected cases by immunohistochemistry. 
      RESULTS: Sixty eight per cent (68% = 52/77) of all patients were HHV-6 DNA 
      positive in any of the samples, 49% (38/77) were positive in tumor tissue. 
      Specimens of just one patient were HHV-6A DNA positive, all other patients were 
      positive for HHV-6B. Immunohistochemical analysis of HHV-6 DNA positive samples 
      did not reveal any specific HHV-6B protein positive tumor cell. In contrast, 
      supposed immune cells presented intra- and peritumorally expressed 
      HHV-6B-protein. The cause of presence of these cells in the tumor stroma is 
      unknown, as of yet. CONCLUSIONS: HHV-6 DNA-positivity of pancreatic cancer tissue 
      described by us and others is probably not due to the infection of pancreatic 
      cells by HHV-6, but rather due to the migration of HHV-6 positive immune cells 
      into the pancreas. Based on our data, we suppose that there is no direct evidence 
      for HHV-6 as a causative agent of pancreatic cancer, but further in-depth studies 
      (including investigation of immune status of patients) are necessary to make 
      definitive conclusions.
CI  - (c) 2023. The Author(s).
FAU - Warkentin, S
AU  - Warkentin S
AD  - RWTH Aachen University DE, Aachen, Germany.
FAU - Braunschweig, T A
AU  - Braunschweig TA
AD  - RWTH Aachen University DE, Aachen, Germany.
FAU - Jonigk, D
AU  - Jonigk D
AD  - RWTH Aachen University DE, Aachen, Germany.
FAU - Losen, I
AU  - Losen I
AD  - RWTH Aachen University DE, Aachen, Germany.
FAU - Cassataro, M A
AU  - Cassataro MA
AD  - RWTH Aachen University DE, Aachen, Germany.
FAU - Kleines, M
AU  - Kleines M
AD  - RWTH Aachen University DE, Aachen, Germany. mkleines@ukaachen.de.
LA  - eng
PT  - Journal Article
DEP - 20231114
PL  - England
TA  - Diagn Pathol
JT  - Diagnostic pathology
JID - 101251558
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Humans
MH  - *Herpesvirus 6, Human/genetics
MH  - *Adenocarcinoma
MH  - *Roseolovirus Infections/diagnosis/genetics
MH  - *Pancreatic Neoplasms
MH  - DNA, Viral/genetics
MH  - *Carcinoma, Pancreatic Ductal
PMC - PMC10644576
COIS- The authors declare no competing interests.
EDAT- 2023/11/15 06:42
MHDA- 2023/11/16 06:44
PMCR- 2023/11/14
CRDT- 2023/11/15 00:01
PHST- 2023/08/20 00:00 [received]
PHST- 2023/10/17 00:00 [accepted]
PHST- 2023/11/16 06:44 [medline]
PHST- 2023/11/15 06:42 [pubmed]
PHST- 2023/11/15 00:01 [entrez]
PHST- 2023/11/14 00:00 [pmc-release]
AID - 10.1186/s13000-023-01402-z [pii]
AID - 1402 [pii]
AID - 10.1186/s13000-023-01402-z [doi]
PST - epublish
SO  - Diagn Pathol. 2023 Nov 14;18(1):124. doi: 10.1186/s13000-023-01402-z.