PMID- 37964437
OWN - NLM
STAT- MEDLINE
DCOM- 20240305
LR  - 20240305
IS  - 1469-8978 (Electronic)
IS  - 0033-2917 (Linking)
VI  - 54
IP  - 4
DP  - 2024 Mar
TI  - Near-infrared spectroscopy and electroencephalography neurofeedback for 
      binge-eating disorder: an exploratory randomized trial.
PG  - 675-686
LID - 10.1017/S0033291723002350 [doi]
AB  - BACKGROUND: Binge-eating disorder (BED) co-occurs with neurobehavioral 
      alterations in the processing of disorder-relevant content such as visual food 
      stimuli. Whether neurofeedback (NF) directly targeting them is suited for 
      treatment remains unclear. This study sought to determine feasibility and 
      estimate effects of individualized, functional near-infrared spectroscopy-based 
      real-time NF (rtfNIRS-NF) and high-beta electroencephalography-based NF (EEG-NF), 
      assuming superiority over waitlist (WL). METHODS: Single-center, assessor-blinded 
      feasibility study with randomization to rtfNIRS-NF, EEG-NF, or WL and assessments 
      at baseline (t0), postassessment (t1), and 6-month follow-up (t2). NF comprised 
      12 60-min food-specific rtfNIRS-NF or EEG-NF sessions over 8 weeks. Primary 
      outcome was the binge-eating frequency at t1 assessed interview-based. Secondary 
      outcomes included feasibility, eating disorder symptoms, mental and physical 
      health, weight management-related behavior, executive functions, and brain 
      activity at t1 and t2. RESULTS: In 72 patients (intent-to-treat), the results 
      showed feasibility of NF regarding recruitment, attrition, adherence, compliance, 
      acceptance, and assessment completion. Binge eating improved at t1 by -8.0 
      episodes, without superiority of NF v. WL (-0.8 episodes, 95% CI -2.4 to 4.0), 
      but with improved estimates in NF at t2 relative to t1. NF was better than WL for 
      food craving, anxiety symptoms, and body mass index, but overall effects were 
      mostly small. Brain activity changes were near zero. CONCLUSIONS: The results 
      show feasibility of food-specific rtfNIRS-NF and EEG-NF in BED, and no 
      posttreatment differences v. WL, but possible continued improvement of binge 
      eating. Confirmatory and mechanistic evidence is warranted in a double-blind 
      randomized design with long-term follow-up, considering dose-response 
      relationships and modes of delivery.
FAU - Hilbert, Anja
AU  - Hilbert A
AUID- ORCID: 0000-0003-2775-1296
AD  - Integrated Research and Treatment Center AdiposityDiseases, Behavioral Medicine 
      Research Unit, Department of Psychosomatic Medicine and Psychotherapy, Leipzig 
      University Medical Center, Leipzig, Germany.
FAU - Rosch, Sarah Alica
AU  - Rosch SA
AUID- ORCID: 0000-0001-5439-8147
AD  - Integrated Research and Treatment Center AdiposityDiseases, Behavioral Medicine 
      Research Unit, Department of Psychosomatic Medicine and Psychotherapy, Leipzig 
      University Medical Center, Leipzig, Germany.
FAU - Petroff, David
AU  - Petroff D
AD  - Clinical Trial Centre Leipzig, University of Leipzig, Leipzig, Germany.
FAU - Prettin, Christiane
AU  - Prettin C
AD  - Clinical Trial Centre Leipzig, University of Leipzig, Leipzig, Germany.
FAU - Luhrs, Michael
AU  - Luhrs M
AD  - Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The 
      Netherlands.
AD  - Brain Innovation B.V., Maastricht, The Netherlands.
FAU - Ehlis, Ann-Christin
AU  - Ehlis AC
AD  - Department of Psychiatry and Psychotherapy, University Hospital of Tuebingen, 
      Tuebingen, Germany.
FAU - Schmidt, Ricarda
AU  - Schmidt R
AUID- ORCID: 0000-0001-7794-2897
AD  - Integrated Research and Treatment Center AdiposityDiseases, Behavioral Medicine 
      Research Unit, Department of Psychosomatic Medicine and Psychotherapy, Leipzig 
      University Medical Center, Leipzig, Germany.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20231115
PL  - England
TA  - Psychol Med
JT  - Psychological medicine
JID - 1254142
SB  - IM
MH  - Humans
MH  - *Binge-Eating Disorder/therapy
MH  - *Neurofeedback/methods
MH  - Obesity
MH  - Spectroscopy, Near-Infrared
MH  - Electroencephalography
MH  - *Bulimia
MH  - Treatment Outcome
OTO - NOTNLM
OT  - binge-eating disorder
OT  - electroencephalography
OT  - near-infrared spectroscopy
OT  - neurofeedback
OT  - obesity
OT  - treatment
EDAT- 2023/11/15 06:42
MHDA- 2024/03/05 06:47
CRDT- 2023/11/15 00:06
PHST- 2024/03/05 06:47 [medline]
PHST- 2023/11/15 06:42 [pubmed]
PHST- 2023/11/15 00:06 [entrez]
AID - S0033291723002350 [pii]
AID - 10.1017/S0033291723002350 [doi]
PST - ppublish
SO  - Psychol Med. 2024 Mar;54(4):675-686. doi: 10.1017/S0033291723002350. Epub 2023 
      Nov 15.