PMID- 37965279
OWN - NLM
STAT- MEDLINE
DCOM- 20231116
LR  - 20240513
IS  - 1178-2013 (Electronic)
IS  - 1176-9114 (Print)
IS  - 1176-9114 (Linking)
VI  - 18
DP  - 2023
TI  - Potential Efficacy of Herbal Medicine-Derived Carbon Dots in the Treatment of 
      Diseases: From Mechanism to Clinic.
PG  - 6503-6525
LID - 10.2147/IJN.S431061 [doi]
AB  - Carbon dots (CDs), a crucial component of nanomaterials, are zero-dimensional 
      nanomaterials with carbon as the backbone structure and smaller than 10 nm. Due 
      to their beneficial characteristics, they are widely used in biomedical fields 
      such as biosensors, drug delivery, bio-imaging, and interactions with DNA. 
      Interestingly, a novel type of carbon dot, generated by using herbal medicines as 
      synthetic raw materials, has emerged as the most recent incomer in the family of 
      CDs with the extensive growth in the number of materials selected for carbon dots 
      synthesis. Herbal medicine-derived carbon dots (HM-CDs) have been employed in the 
      biomedical industry, and are rapidly emerging as "modern nanomaterials" due to 
      their unique structures and exceptional capabilities. Emerging trends suggest 
      that their specific properties can be used in bleeding disorders, 
      gastrointestinal disorders, inflammation-related diseases, and other common 
      intractable diseases including cancer, menopausal syndrome, central nervous 
      system disorders, and pain of various forms and causes. In addition, HM-CDs have 
      been found to have organ-protective and antioxidant properties, as evidenced by 
      extensive studies. This research provides a more comprehensive understanding of 
      the biomedical applications of HM-CDs for the aforementioned disorders and 
      investigates the intrinsic pharmacological activities and mechanisms of these 
      HM-CDs to further advance their clinical applications.
CI  - (c) 2023 Zeng et al.
FAU - Zeng, Mingtang
AU  - Zeng M
AD  - Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, 610041, 
      People's Republic of China.
FAU - Wang, Yao
AU  - Wang Y
AD  - Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, 610041, 
      People's Republic of China.
FAU - Liu, Maozhu
AU  - Liu M
AD  - Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, 610041, 
      People's Republic of China.
FAU - Wei, Yuxun
AU  - Wei Y
AUID- ORCID: 0000-0001-9723-1611
AD  - Department of Pharmacy, Zhongjiang County People's Hospital, Deyang, 618000, 
      People's Republic of China.
FAU - Wen, Jie
AU  - Wen J
AD  - Department of Pharmacy, Shehong Municipal Hospital of Traditional Chinese 
      Medicine, Shehong, 629600, People's Republic of China.
FAU - Zhang, Yuchen
AU  - Zhang Y
AD  - Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, 610041, 
      People's Republic of China.
FAU - Chen, Tao
AU  - Chen T
AD  - Key Laboratory of Medical Electrophysiology, Ministry of Education, School of 
      Pharmacy of Southwest Medical University, Luzhou, 646000, People's Republic of 
      China.
FAU - He, Nianyu
AU  - He N
AD  - Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, 610041, 
      People's Republic of China.
FAU - Fan, Ping
AU  - Fan P
AD  - Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, 610041, 
      People's Republic of China.
FAU - Dai, Xinhua
AU  - Dai X
AD  - Department of Laboratory Medicine, West China Hospital, Sichuan University, 
      Chengdu, 610041, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231109
PL  - New Zealand
TA  - Int J Nanomedicine
JT  - International journal of nanomedicine
JID - 101263847
RN  - 7440-44-0 (Carbon)
RN  - 0 (Plant Extracts)
SB  - IM
EIN - Int J Nanomedicine. 2024 May 07;19:4043-4044. PMID: 38736652
MH  - Humans
MH  - Carbon/chemistry
MH  - *Quantum Dots/therapeutic use/chemistry
MH  - Herbal Medicine
MH  - *Neoplasms/drug therapy
MH  - Plant Extracts
PMC - PMC10642355
OTO - NOTNLM
OT  - carbon dots
OT  - disease treatment
OT  - herbal medicine
OT  - nanomaterials
OT  - potential mechanism
COIS- The authors declare that they have no competing interests in this work.
EDAT- 2023/11/15 06:42
MHDA- 2023/11/16 06:44
PMCR- 2023/11/09
CRDT- 2023/11/15 04:22
PHST- 2023/07/18 00:00 [received]
PHST- 2023/10/24 00:00 [accepted]
PHST- 2023/11/16 06:44 [medline]
PHST- 2023/11/15 06:42 [pubmed]
PHST- 2023/11/15 04:22 [entrez]
PHST- 2023/11/09 00:00 [pmc-release]
AID - 431061 [pii]
AID - 10.2147/IJN.S431061 [doi]
PST - epublish
SO  - Int J Nanomedicine. 2023 Nov 9;18:6503-6525. doi: 10.2147/IJN.S431061. 
      eCollection 2023.