PMID- 37965760
OWN - NLM
STAT- MEDLINE
DCOM- 20231206
LR  - 20231217
IS  - 1520-4898 (Electronic)
IS  - 0001-4842 (Linking)
VI  - 56
IP  - 23
DP  - 2023 Dec 5
TI  - Emerging Roles of RNA Methylation in Development.
PG  - 3417-3427
LID - 10.1021/acs.accounts.3c00448 [doi]
AB  - More than 170 different types of chemical modifications have been identified on 
      diverse types of RNA, collectively known as the epitranscriptome. Among them, 
      N(6)-methyladenine (m(6)A), 5-methylcytosine (m(5)C), N(1)-methyladenine (m(1)A), 
      and N(7)-methylguanosine (m(7)G) as the ubiquitous post-transcriptional 
      modification are widely involved in regulating the metabolic processes such as 
      RNA degradation, translation, stability, and export, mediating important 
      physiological and pathological processes such as stress regulation, immune 
      response, development, and tumorigenesis. Recently, the regulatory role of RNA 
      modification during developmental processes is getting more attention. Therefore, 
      the development of low-input even single-cell and high-resolution sequencing 
      technologies is crucial for the exploration of the regulatory roles of RNA 
      modifications in these important biological events of trace samples.This account 
      focuses on the roles of RNA modifications in various developmental processes. We 
      describe the distribution characteristics of various RNA modifications, catalytic 
      enzymes, binding proteins, and the development of sequencing technologies. RNA 
      modification is dynamically reversible, which can be catalyzed by 
      methyltransferases and eliminated by demethylases. RNA m(6)A is the most abundant 
      post-transcriptional modification on eukaryote mRNA, which is mainly concentrated 
      near the stop codon, and involves in RNA metabolism regulation. RNA m(5)C, 
      another most studied RNA modification, has been identified in a various of 
      organisms and RNA species, mainly enriched in the regions downstream of 
      translation initiation sites and broadly distributes across the whole coding 
      sequence (CDS) in mammalian mRNAs. RNA m(1)A, with a lower abundance than m(6)A, 
      is widely distributed in various RNA types, mainly locates in the 5' untranslated 
      region (5'UTR) of mRNA and regulates translation. RNA m(7)G, one of the most 
      common RNA modifications in eukaryotes, has been identified at cap regions and 
      internal positions of RNAs and recently gained considerable attention.Thanks to 
      the development of sequencing technology, m(6)A has been found to regulate the 
      tumorigenic process, including tumor proliferation, invasion, and metastasis by 
      modulating oncogenes and tumor suppressor genes, and affect oocyte maturation and 
      embryonic development through regulating maternal and zygotic genes. m(5)C 
      related proteins have been identified to participate in embryonic development, 
      plant growth, and neural stem cell differentiation in a m(5)C dependent manner. 
      m(1)A also has been revealed to be involved in these developmental processes. 
      m(7)G dysregulation mainly involves in neurodevelopmental disorders and 
      neurodegenerative diseases.Collectively, we summarized the gradually exhibited 
      roles of RNA methylation during development, and discussed the possibility of RNA 
      modifications as candidate biomarkers and potential therapeutic targets. The 
      technological development is anticipated as the major driving force to expand our 
      knowledge in this field.
FAU - Wang, Meng-Ke
AU  - Wang MK
AD  - CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation 
      Center of Genetics and Development, College of Future Technology, Beijing 
      Institute of Genomics, Chinese Academy of Sciences and China National Center for 
      Bioinformation, Beijing 100101, P. R. China.
FAU - Gao, Chun-Chun
AU  - Gao CC
AD  - CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation 
      Center of Genetics and Development, College of Future Technology, Beijing 
      Institute of Genomics, Chinese Academy of Sciences and China National Center for 
      Bioinformation, Beijing 100101, P. R. China.
FAU - Yang, Yun-Gui
AU  - Yang YG
AD  - CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation 
      Center of Genetics and Development, College of Future Technology, Beijing 
      Institute of Genomics, Chinese Academy of Sciences and China National Center for 
      Bioinformation, Beijing 100101, P. R. China.
AD  - Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, 
      P. R. China.
AD  - Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 
      100101, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231115
PL  - United States
TA  - Acc Chem Res
JT  - Accounts of chemical research
JID - 0157313
RN  - 63231-63-0 (RNA)
RN  - 0 (RNA, Messenger)
RN  - EC 2.1.1.- (Methyltransferases)
SB  - IM
MH  - Animals
MH  - Methylation
MH  - *RNA/genetics/metabolism
MH  - RNA, Messenger/metabolism
MH  - *Methyltransferases/genetics/metabolism
MH  - Cell Differentiation
MH  - RNA Processing, Post-Transcriptional
MH  - Mammals/genetics/metabolism
EDAT- 2023/11/15 06:42
MHDA- 2023/12/06 06:42
CRDT- 2023/11/15 05:28
PHST- 2023/12/06 06:42 [medline]
PHST- 2023/11/15 06:42 [pubmed]
PHST- 2023/11/15 05:28 [entrez]
AID - 10.1021/acs.accounts.3c00448 [doi]
PST - ppublish
SO  - Acc Chem Res. 2023 Dec 5;56(23):3417-3427. doi: 10.1021/acs.accounts.3c00448. 
      Epub 2023 Nov 15.