PMID- 37966444
OWN - NLM
STAT- MEDLINE
DCOM- 20231116
LR  - 20231116
IS  - 1997-7298 (Print)
IS  - 1997-7298 (Linking)
VI  - 123
IP  - 10
DP  - 2023
TI  - [Therapy of asthenic disorders after psychotic conditions in patients with 
      cognitive impairment: results of an observational non-interventional program].
PG  - 81-87
LID - 10.17116/jnevro202312310181 [doi]
AB  - OBJECTIVE: An observational non-interventional study was conducted to obtain data 
      on the efficacy and safety of Prospekta in the treatment of postpsychotic 
      asthenia in patients with cognitive impairment (CI). MATERIAL AND METHODS: We 
      selected 69 patients aged 18-75 years with asthenic disorders that developed 
      after suffering psychotic conditions and CI, who were prescribed Prospekta. At 
      four visits (at baseline, after 2, 4 and 8 weeks), the doctor collected 
      complaints, anamnesis, examined the patient, assessed the severity of asthenia on 
      the MFI-20 (The Multidimensional Fatigue Inventory-20) scale, CI - on the MMSE 
      (The Mini-mental state examination). Concomitant diseases and maintenance therapy 
      of the underlying disease were recorded, and the safety of treatment with 
      Prospect was evaluated. At the last visit, the doctor's clinical impression was 
      assessed using the CGI-I (Clinical Global Impression - Global Improvement Scale). 
      RESULTS: The analysis included data from 69 patients (mean age 45.7 years), of 
      which 27 (33.4%) were women. Prospekta reduced the severity of asthenia on the 
      MFI-20 scale from 85.7+/-6.6 to 51.6+/-7.1 points, including general asthenia, mental 
      and physical asthenia, and contributed to an increase in activity and motivation 
      (p<0.001). 8-week treatment with Prospekta improved cognitive function on the 
      MMSE scale from 25.7+/-3.7 to 28.8+/-1.5 points (p<0.001). There was no effect of the 
      drug on blood pressure, heart rate. 76 adverse events (AEs) were detected in 22 
      patients, of which 62 AEs (82%) were of mild severity, 14 AEs (18%) were of 
      moderate severity. A causal relationship of AEs with taking Prospekta, according 
      to doctors, was absent in 48 (63%) cases. CONCLUSION: Prospekta is an effective 
      and safe drug for the treatment of asthenic disorders that have developed after 
      suffering psychotic conditions in patients with CI.
FAU - Chubarovsky, V V
AU  - Chubarovsky VV
AUID- ORCID: 0000-0002-4108-6969
AD  - Sechenov First Moscow State Medical University (Sechenov University), Moscow, 
      Russia.
FAU - Vanchakova, N P
AU  - Vanchakova NP
AUID- ORCID: 0000-0003-1997-0202
AD  - Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia.
FAU - Zun, S A
AU  - Zun SA
AD  - Kirov Military Medical Academy, St. Petersburg, Russia.
FAU - Parashchenko, A F
AU  - Parashchenko AF
AUID- ORCID: 0009-0000-0124-5227
AD  - Razumovsky Saratov State Medical University, Saratov, Russia.
FAU - Kolyago, O O
AU  - Kolyago OO
AUID- ORCID: 0000-0001-7595-1239
AD  - Blokhin National Medical Research Center of Oncology, Moscow, Russia.
AD  - Mental Health Research Center, Moscow, Russia.
FAU - Potapov, I V
AU  - Potapov IV
AUID- ORCID: 0009-0000-4681-8199
AD  - Sechenov First Moscow State Medical University (Sechenov University), Moscow, 
      Russia.
FAU - Savchenkov, V A
AU  - Savchenkov VA
AUID- ORCID: 0000-0002-4953-3233
AD  - Korsakov Clinic of Psychiatry, Moscow, Russia.
FAU - Ushkalova, A V
AU  - Ushkalova AV
AUID- ORCID: 0000-0002-8030-8077
AD  - Medical Center <<Granat>>, Moscow, Russia.
LA  - rus
PT  - English Abstract
PT  - Journal Article
PT  - Observational Study
TT  - Terapiya astenicheskikh rasstroistv posle perenesennykh psikhoticheskikh 
      sostoyanii u patsientov s kognitivnymi narusheniyami: rezul'taty nablyudatel'noi 
      neinterventsionnoi programmy.
PL  - Russia (Federation)
TA  - Zh Nevrol Psikhiatr Im S S Korsakova
JT  - Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
JID - 9712194
SB  - IM
MH  - Humans
MH  - Female
MH  - Middle Aged
MH  - Male
MH  - *Asthenia/drug therapy/etiology
MH  - *Cognitive Dysfunction/etiology
MH  - Cognition
MH  - Blood Pressure
MH  - Heart Rate
OTO - NOTNLM
OT  - Prospekta
OT  - asthenia
OT  - cognitive impairment
OT  - observational non-interventional study
OT  - psychotic disorders
EDAT- 2023/11/15 12:43
MHDA- 2023/11/16 06:45
CRDT- 2023/11/15 10:47
PHST- 2023/11/16 06:45 [medline]
PHST- 2023/11/15 12:43 [pubmed]
PHST- 2023/11/15 10:47 [entrez]
AID - 10.17116/jnevro202312310181 [doi]
PST - ppublish
SO  - Zh Nevrol Psikhiatr Im S S Korsakova. 2023;123(10):81-87. doi: 
      10.17116/jnevro202312310181.