PMID- 3796789
OWN - NLM
STAT- MEDLINE
DCOM- 19870211
LR  - 20180214
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 44
IP  - 2
DP  - 1986
TI  - Potent action of leumorphin on consummatory behaviors in rats: comparison with 
      other opioid peptides.
PG  - 142-8
AB  - Leumorphin is a 29-amino-acid peptide derived from preproenkephalin B. 
      Intracerebroventricular (i.c.v.) injection of leumorphin through an implanted 
      cannula into the lateral ventricle of rats dose-dependently inhibited water 
      intake induced by water deprivation, angiotensin II (AII) and carbachol. This 
      effect was partially reversed by intraperitoneal injection of naloxone, an opiate 
      antagonist. Naloxone alone rather attenuated water intake. The antidipsogenic 
      effect of leumorphin was very potent: 0.6 pmol of the peptide significantly 
      inhibited AII-induced drinking. Dynorphin 1-17 was almost as potent as leumorphin 
      in inhibiting drinking, whereas alpha-neo-endorphin and leucine-enkephalin 
      (Leu-enkephalin) were far less effective. Leumorphin given i.c.v. 
      dose-dependently enhanced eating and this effect was abolished by naloxone. 
      Dynorphin was as potent as leumorphin in inducing feeding, whereas 
      alpha-neo-endorphin and Leu-enkephalin had no significant activity when 6 nmol 
      was used. General activity measured by an Automex was enhanced by i.c.v. 
      injection of leumorphin but required larger amounts of the peptide than did 
      drinking behavior. The very potent and specific effects of leumorphin and 
      dynorphin on drinking behavior suggest that the antidipsogenic activity of these 
      peptides is of physiological significance like their effect on feeding.
FAU - Imura, H
AU  - Imura H
FAU - Nakao, K
AU  - Nakao K
FAU - Yanaihara, N
AU  - Yanaihara N
FAU - Katsuura, G
AU  - Katsuura G
FAU - Nakamura, M
AU  - Nakamura M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 0 (Endorphins)
RN  - 0 (Enkephalins)
RN  - 0 (Protein Precursors)
RN  - 11128-99-7 (Angiotensin II)
RN  - 36B82AMQ7N (Naloxone)
RN  - 8Y164V895Y (Carbachol)
RN  - 93443-35-7 (preproenkephalin)
SB  - IM
MH  - Angiotensin II/physiology
MH  - Animals
MH  - Carbachol/pharmacology
MH  - Drinking Behavior/drug effects/*physiology
MH  - Endorphins/*physiology
MH  - Enkephalins/*physiology
MH  - Feeding Behavior/drug effects/*physiology
MH  - Injections, Intraventricular
MH  - Male
MH  - Motor Activity/drug effects/physiology
MH  - Naloxone/pharmacology
MH  - Protein Precursors/*physiology
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 10.1159/000124637 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1986;44(2):142-8. doi: 10.1159/000124637.