PMID- 37969017
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231213
IS  - 1477-0539 (Electronic)
IS  - 1477-0520 (Linking)
VI  - 21
IP  - 48
DP  - 2023 Dec 13
TI  - Visible light mediated synthesis of 1,3-diarylated imidazo[1,5-a]pyridines via 
      oxidative amination of C-H catalyzed by graphitic carbon nitride.
PG  - 9552-9561
LID - 10.1039/d3ob01636f [doi]
AB  - Graphitic carbon nitride (g-C(3)N(4)) as a novel heterogeneous catalyst is 
      employed for the visible light-mediated synthesis of the imidazo[1,5-a]pyridines 
      via the oxidative amination of C-H bond at room temperature without the need for 
      any additional solvent. Extensive characterization of the catalyst was performed 
      using techniques such as FT-IR, PXRD, TGA, SEM and EDX analysis. The optimized 
      conditions enabled the successful and expeditious conversion of a wide range of 
      substrates to imidazo[1,5-a]pyridines in good yields; a notable advantage of this 
      catalyst being recyclability, as it can be reused for up to five cycles without 
      significant loss of activity. This feature makes it suitable for gram-scale 
      synthesis of imidazo[1,5-a]pyridines. Additionally, this approach offers several 
      benefits from a green chemistry perspective as affirmed by its favorable green 
      chemistry metrics (GCM), including low process mass intensity (PMI), low 
      E-factor, high atom economy (AE), and good reaction mass efficiency (RME) 
      relative to existing protocols. In addition, chemical yield (CY), mass intensity 
      (MI), mass productivity (MP) and optimum efficiency were also calculated. This 
      environmentally friendly method offers multiple advantages and represents a 
      significant advancement in the synthesis of imidazo[1,5-a]pyridines.
FAU - Talpada, Nandish
AU  - Talpada N
AD  - Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, 
      Gujarat 380009, India. vinaysharma3836@gmail.com.
FAU - Sharma, Anuj S
AU  - Sharma AS
AD  - Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, 
      Gujarat 380009, India. vinaysharma3836@gmail.com.
FAU - Sharma, Vinay S
AU  - Sharma VS
AUID- ORCID: 0000-0003-4970-0676
AD  - Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, 
      Gujarat 380009, India. vinaysharma3836@gmail.com.
FAU - Varma, Rajender S
AU  - Varma RS
AUID- ORCID: 0000-0001-9731-6228
AD  - Centre of Excellence for Research in Sustainable Chemistry, Department of 
      Chemistry, Federal University of Sao Carlos, 13565-905 Sao Carlos, SP, Brazil.
FAU - Shrivastav, Pranav S
AU  - Shrivastav PS
AUID- ORCID: 0000-0002-1284-1558
AD  - Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, 
      Gujarat 380009, India. vinaysharma3836@gmail.com.
FAU - Ahmed, Rahul
AU  - Ahmed R
AD  - Department of Chemistry, Indian Institute of Technology, Guwahati, 781039, Assam, 
      India. achalkumar@iitg.ac.in.
FAU - Ammathnadu Sudhakar, Achalkumar
AU  - Ammathnadu Sudhakar A
AUID- ORCID: 0000-0003-4952-9450
AD  - Department of Chemistry, Indian Institute of Technology, Guwahati, 781039, Assam, 
      India. achalkumar@iitg.ac.in.
AD  - Centre for Sustainable Polymers, Indian Institute of Technology, Guwahati, 
      781039, Assam, India.
LA  - eng
PT  - Journal Article
DEP - 20231213
PL  - England
TA  - Org Biomol Chem
JT  - Organic & biomolecular chemistry
JID - 101154995
SB  - IM
EDAT- 2023/11/16 06:45
MHDA- 2023/11/16 06:46
CRDT- 2023/11/16 03:45
PHST- 2023/11/16 06:46 [medline]
PHST- 2023/11/16 06:45 [pubmed]
PHST- 2023/11/16 03:45 [entrez]
AID - 10.1039/d3ob01636f [doi]
PST - epublish
SO  - Org Biomol Chem. 2023 Dec 13;21(48):9552-9561. doi: 10.1039/d3ob01636f.