PMID- 37970127
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231117
IS  - 1948-9358 (Print)
IS  - 1948-9358 (Electronic)
IS  - 1948-9358 (Linking)
VI  - 14
IP  - 10
DP  - 2023 Oct 15
TI  - Effects of vitamin D supplementation on glucose and lipid metabolism in patients 
      with type 2 diabetes mellitus and risk factors for insulin resistance.
PG  - 1514-1523
LID - 10.4239/wjd.v14.i10.1514 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease 
      featured by insulin resistance (IR) and decreased insulin secretion. Currently, 
      vitamin D deficiency is found in most patients with T2DM, but the relationship 
      between vitamin D and IR in T2DM patients requires further investigation. AIM: To 
      explore the risk factors of IR and the effects of vitamin D supplementation on 
      glucose and lipid metabolism in patients with T2DM. METHODS: Clinical data of 162 
      T2DM patients treated in First Affiliated Hospital of Harbin Medical University 
      between January 2019 and February 2022 were retrospectively analyzed. Based on 
      the diagnostic criteria of IR, the patients were divided into a resistance group 
      (n = 100) and a non-resistance group (n = 62). Subsequently, patients in the 
      resistance group were subdivided to a conventional group (n = 44) or a joint 
      group (n = 56) according to the treatment regimens. Logistic regression was 
      carried out to analyze the risk factors of IR in T2DM patients. The changes in 
      glucose and lipid metabolism indexes in T2DM patients with vitamin D deficiency 
      were evaluated after the treatment. RESULTS: Notable differences were observed in 
      age and body mass index (BMI) between the resistance group and the non-resistance 
      group (both P < 0.05). The resistance group exhibited a lower 25-hydroxyvitamin 
      D(3) (25(OH)D(3)) level, as well as notably higher levels of 2-h postprandial 
      blood glucose (2hPG), fasting blood glucose (FBG), and glycosylated hemoglobin 
      (HbA1c) than the non-resistance group (all P < 0.0001). Additionally, the 
      resistance group demonstrated a higher triglyceride (TG) level but a lower 
      high-density lipoprotein-cholesterol (HDL-C) level than the non-resistance group 
      (all P < 0.0001). The BMI, TG, HDL-C, 25(OH)D(3), 2hPG, and HbA1c were found to 
      be risk factors of IR. Moreover, the post-treatment changes in levels of 
      25(OH)D(3), 2hPG, FBG and HbA1c, as well as TG, total cholesterol, and HDL-C in 
      the joint group were more significant than those in the conventional group (all P 
      < 0.05). CONCLUSION: Patients with IR exhibit significant abnormalities in 
      glucose and lipid metabolism parameters compared to the non-insulin resistant 
      group. Logistic regression analysis revealed that 25(OH)D(3) is an independent 
      risk factor influencing IR. Supplementation of vitamin D has been shown to 
      improve glucose and lipid metabolism in patients with IR and T2DM.
CI  - (c)The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Sun, Li-Jie
AU  - Sun LJ
AD  - Department of Endocrinology, First Affiliated Hospital of Harbin Medical 
      University, Harbin 150001, Heilongjiang Province, China.
FAU - Lu, Ji-Xuan
AU  - Lu JX
AD  - Department of Endocrinology, First Affiliated Hospital of Harbin Medical 
      University, Harbin 150001, Heilongjiang Province, China.
FAU - Li, Xin-Yu
AU  - Li XY
AD  - Department of Endocrinology, First Affiliated Hospital of Harbin Medical 
      University, Harbin 150001, Heilongjiang Province, China.
FAU - Zheng, Tian-Sheng
AU  - Zheng TS
AD  - Department of Endocrinology, Southern University of Science and Technology 
      Hospital, Shenzhen 518071, Guangdong Province, China.
FAU - Zhan, Xiao-Rong
AU  - Zhan XR
AD  - Department of Endocrinology, First Affiliated Hospital of Harbin Medical 
      University, Harbin 150001, Heilongjiang Province, China.
AD  - Department of Endocrinology, Southern University of Science and Technology 
      Hospital, Shenzhen 518071, Guangdong Province, China xiaorongzhandoctor@126.com.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Diabetes
JT  - World journal of diabetes
JID - 101547524
PMC - PMC10642416
OTO - NOTNLM
OT  - Glucose and lipid metabolism
OT  - Insulin resistance
OT  - Risk factors
OT  - Type 2 diabetes mellitus
OT  - Vitamin D
COIS- Conflict-of-interest statement: All the authors report no relevant conflicts of 
      interest for this article.
EDAT- 2023/11/16 06:45
MHDA- 2023/11/16 06:46
PMCR- 2023/10/15
CRDT- 2023/11/16 04:28
PHST- 2023/06/20 00:00 [received]
PHST- 2023/07/19 00:00 [revised]
PHST- 2023/08/15 00:00 [accepted]
PHST- 2023/11/16 06:46 [medline]
PHST- 2023/11/16 06:45 [pubmed]
PHST- 2023/11/16 04:28 [entrez]
PHST- 2023/10/15 00:00 [pmc-release]
AID - 10.4239/wjd.v14.i10.1514 [doi]
PST - ppublish
SO  - World J Diabetes. 2023 Oct 15;14(10):1514-1523. doi: 10.4239/wjd.v14.i10.1514.