PMID- 37971539 OWN - NLM STAT- MEDLINE DCOM- 20231120 LR - 20231129 IS - 1552-9924 (Electronic) IS - 0091-6765 (Print) IS - 0091-6765 (Linking) VI - 131 IP - 11 DP - 2023 Nov TI - Prenatal Exposure to Perfluoroalkyl Substances and Child Behavior at Age 12: A PELAGIE Mother-Child Cohort Study. PG - 117009 LID - 10.1289/EHP12540 [doi] LID - 117009 AB - BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are chemical substances spread throughout the environment worldwide. Exposure during pregnancy represents a specific window of vulnerability for child health. OBJECTIVE: Our objective was to assess the impact of prenatal exposure to multiple PFAS on emotional and behavioral functions in 12-y-old children. METHOD: In the PELAGIE mother-child cohort (France), prenatal exposure to nine PFAS was measured from concentrations in cord serum samples. Behavior was assessed at age 12 y using the parent-reported Strengths and Difficulties Questionnaire (SDQ) and the self-reported Dominic Interactive for Adolescents (DIA) for 444 children. Associations were estimated using negative binomial models for each PFAS. Bayesian kernel machine regression (BKMR) models were performed to assess the exposure mixture effect on children's behavior. RESULTS: In our study population, 73% of mothers had spent more than 12 y in education. Higher scores on SDQ externalizing subscale were observed with increasing cord-serum concentration of perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA) [adjusted mean ratio (aMR) = 1.18, 95% confidence interval (CI): 1.03, 1.34, and aMR = 1.14 (95% CI: 1.00, 1.29) for every doubling of concentration, respectively]. Results for the hyperactivity score were similar [aMR = 1.20 (95% CI: 1.04, 1.40) and aMR = 1.18 (95% CI: 1.02, 1.36), respectively]. With regard to major depressive disorder and internalizing subscales, perfluorodecanoic acid (PFDA) was associated with higher self-reported DIA scores [aMR = 1.14 (95% CI: 1.01, 1.27) and aMR = 1.11 (95% CI: 1.02, 1.21), respectively]. In terms of the anxiety subscale, PFDA and PFNA were associated with higher scores [aMR = 1.11 (95% CI: 1.02, 1.21) and aMR = 1.10 (95% CI: 1.01, 1.19), respectively]. Concurrent increases in the PFAS concentrations included in the BKMR models showed no change in the SDQ externalizing and DIA internalizing subscales scores. CONCLUSION: Prenatal exposure to PFNA and PFOA were associated with increasing scores for measures of externalizing behaviors, specifically hyperactivity. We also identified associations between PFNA and PFDA prenatal exposure levels and increasing scores related to internalizing behaviors (general anxiety and major depressive disorder), which adds to the as yet sparse literature examining the links between prenatal exposure to PFAS and internalizing disorders. https://doi.org/10.1289/EHP12540. FAU - Tillaut, Helene AU - Tillaut H AD - Institut de recherche en sante, environnement et travail (Irset) - UMR 1085, Universite de Rennes, Institut national de la sante et de la recherche medicale (Inserm), Ecole des hautes etudes en sante publique (EHESP), Rennes, France. FAU - Monfort, Christine AU - Monfort C AD - Institut de recherche en sante, environnement et travail (Irset) - UMR 1085, Universite de Rennes, Institut national de la sante et de la recherche medicale (Inserm), Ecole des hautes etudes en sante publique (EHESP), Rennes, France. FAU - Rouget, Florence AU - Rouget F AD - Irset - UMR_S 1085, Centre hospitalier universitaire (CHU) de Rennes, Universite de Rennes, Inserm, EHESP, Rennes, France. FAU - Pele, Fabienne AU - Pele F AD - Institut de recherche en sante, environnement et travail (Irset) - UMR 1085, Universite de Rennes, Institut national de la sante et de la recherche medicale (Inserm), Ecole des hautes etudes en sante publique (EHESP), Rennes, France. FAU - Laine, Fabrice AU - Laine F AD - CIC 1414, Universite de Rennes, CHU Rennes, Inserm, Rennes, France. FAU - Gaudreau, Eric AU - Gaudreau E AD - Centre de Toxicologie du Quebec (CTQ), Institut national de sante publique du Quebec (INSPQ), Quebec, Quebec, Canada. FAU - Cordier, Sylvaine AU - Cordier S AD - Institut de recherche en sante, environnement et travail (Irset) - UMR 1085, Universite de Rennes, Institut national de la sante et de la recherche medicale (Inserm), Ecole des hautes etudes en sante publique (EHESP), Rennes, France. FAU - Warembourg, Charline AU - Warembourg C AD - Institut de recherche en sante, environnement et travail (Irset) - UMR 1085, Universite de Rennes, Institut national de la sante et de la recherche medicale (Inserm), Ecole des hautes etudes en sante publique (EHESP), Rennes, France. FAU - Saint-Amour, Dave AU - Saint-Amour D AD - Departement de Psychologie, Universite du Quebec a Montreal, Montreal, Quebec, Canada. AD - Centre de Recherche du Centre Hospitalier, Universitaire Sainte-Justine, Montreal, Quebec, Canada. FAU - Chevrier, Cecile AU - Chevrier C AD - Institut de recherche en sante, environnement et travail (Irset) - UMR 1085, Universite de Rennes, Institut national de la sante et de la recherche medicale (Inserm), Ecole des hautes etudes en sante publique (EHESP), Rennes, France. LA - eng PT - Journal Article DEP - 20231116 PL - United States TA - Environ Health Perspect JT - Environmental health perspectives JID - 0330411 RN - 0 (Environmental Pollutants) RN - 0 (Alkanesulfonic Acids) RN - 375-95-1 (perfluoro-n-nonanoic acid) RN - 947VD76D3L (perfluorooctanoic acid) RN - 335-76-2 (perfluorodecanoic acid) RN - 0 (Fluorocarbons) SB - IM MH - Pregnancy MH - Female MH - Adolescent MH - Child MH - Humans MH - Cohort Studies MH - *Prenatal Exposure Delayed Effects/epidemiology MH - *Depressive Disorder, Major MH - Bayes Theorem MH - *Environmental Pollutants MH - *Alkanesulfonic Acids MH - Child Behavior MH - *Fluorocarbons MH - Mother-Child Relations PMC - PMC10653211 EDAT- 2023/11/17 15:29 MHDA- 2023/11/20 06:55 PMCR- 2023/11/16 CRDT- 2023/11/16 11:04 PHST- 2023/11/20 06:55 [medline] PHST- 2023/11/17 15:29 [pubmed] PHST- 2023/11/16 11:04 [entrez] PHST- 2023/11/16 00:00 [pmc-release] AID - EHP12540 [pii] AID - 10.1289/EHP12540 [doi] PST - ppublish SO - Environ Health Perspect. 2023 Nov;131(11):117009. doi: 10.1289/EHP12540. Epub 2023 Nov 16.