PMID- 37971979 OWN - NLM STAT- MEDLINE DCOM- 20231127 LR - 20231127 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 18 IP - 11 DP - 2023 TI - Dataset of single nucleotide polymorphisms of immune-associated genes in patients with SARS-CoV-2 infection. PG - e0287725 LID - 10.1371/journal.pone.0287725 [doi] LID - e0287725 AB - The SARS-CoV-2 pandemic has affected nations globally leading to illness, death, and economic downturn. Why disease severity, ranging from no symptoms to the requirement for extracorporeal membrane oxygenation, varies between patients is still incompletely understood. Consequently, we aimed at understanding the impact of genetic factors on disease severity in infection with SARS-CoV-2. Here, we provide data on demographics, ABO blood group, human leukocyte antigen (HLA) type, as well as next-generation sequencing data of genes in the natural killer cell receptor family, the renin-angiotensin-aldosterone and kallikrein-kinin systems and others in 159 patients with SARS-CoV-2 infection, stratified into seven categories of disease severity. We provide single-nucleotide polymorphism (SNP) data on the patients and a protein structural analysis as a case study on a SNP in the SIGLEC7 gene, which was significantly associated with the clinical score. Our data represent a resource for correlation analyses involving genetic factors and disease severity and may help predict outcomes in infections with future SARS-CoV-2 variants and aid vaccine adaptation. CI - Copyright: (c) 2023 Katsaouni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Katsaouni, Nikoletta AU - Katsaouni N AUID- ORCID: 0000-0001-8323-2824 AD - Computational Epigenomics & Systems Cardiology, Institute of Cardiovascular Regeneration, Goethe University and University Clinic, Frankfurt am Main, Germany. AD - German Center for Cardiovascular Research (DZHK), Partner site Rhein Main, Frankfurt am Main, Germany. AD - Cardio-Pulmonary Institute, Goethe University Hospital, Frankfurt am Main, Germany. FAU - Llavona, Pablo AU - Llavona P AD - Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany. FAU - Khodamoradi, Yascha AU - Khodamoradi Y AUID- ORCID: 0000-0001-5972-0967 AD - Department of Internal Medicine, Infectious Diseases, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany. FAU - Otto, Ann-Kathrin AU - Otto AK AD - Molecular Bioinformatics, Institute of Computer Science, Goethe University Frankfurt am Main, Germany. FAU - Korber, Stephanie AU - Korber S AD - German Red Cross Blood Donor Service Baden-Wurttemberg Hessen, Frankfurt am Main, Germany. FAU - Geisen, Christof AU - Geisen C AD - German Red Cross Blood Donor Service Baden-Wurttemberg Hessen, Frankfurt am Main, Germany. FAU - Seidl, Christian AU - Seidl C AD - German Red Cross Blood Donor Service Baden-Wurttemberg Hessen, Frankfurt am Main, Germany. FAU - Vehreschild, Maria J G T AU - Vehreschild MJGT AD - Department of Internal Medicine, Infectious Diseases, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany. FAU - Ciesek, Sandra AU - Ciesek S AD - Institute for Medical Virology, University Hospital, Goethe University, Frankfurt, Germany. AD - German Centre for Infection Research, External Partner Site, Frankfurt, Germany. AD - Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch Translational Medicine and Pharmacology, Frankfurt, Germany. FAU - Ackermann, Jorg AU - Ackermann J AD - Molecular Bioinformatics, Institute of Computer Science, Goethe University Frankfurt am Main, Germany. FAU - Koch, Ina AU - Koch I AD - Molecular Bioinformatics, Institute of Computer Science, Goethe University Frankfurt am Main, Germany. FAU - Schulz, Marcel H AU - Schulz MH AD - Computational Epigenomics & Systems Cardiology, Institute of Cardiovascular Regeneration, Goethe University and University Clinic, Frankfurt am Main, Germany. AD - German Center for Cardiovascular Research (DZHK), Partner site Rhein Main, Frankfurt am Main, Germany. AD - Cardio-Pulmonary Institute, Goethe University Hospital, Frankfurt am Main, Germany. FAU - Krause, Daniela S AU - Krause DS AD - Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany. AD - German Red Cross Blood Donor Service Baden-Wurttemberg Hessen, Frankfurt am Main, Germany. AD - Institute of Biochemistry II and Institute of General Pharmacology and Toxicology, Goethe-University, Frankfurt am Main, Germany. AD - German Cancer Consortium (DKTK), Frankfurt, Germany. AD - Frankfurt Cancer Institute, Frankfurt am Main, Germany. LA - eng PT - Journal Article DEP - 20231116 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Angiotensins) RN - SARS-CoV-2 variants SB - IM MH - Humans MH - *COVID-19/genetics MH - SARS-CoV-2/genetics MH - Polymorphism, Single Nucleotide MH - Angiotensins PMC - PMC10653545 COIS- The authors have declared that no competing interests exist. EDAT- 2023/11/17 15:23 MHDA- 2023/11/27 12:43 PMCR- 2023/11/16 CRDT- 2023/11/16 13:33 PHST- 2023/02/03 00:00 [received] PHST- 2023/06/09 00:00 [accepted] PHST- 2023/11/27 12:43 [medline] PHST- 2023/11/17 15:23 [pubmed] PHST- 2023/11/16 13:33 [entrez] PHST- 2023/11/16 00:00 [pmc-release] AID - PONE-D-23-03131 [pii] AID - 10.1371/journal.pone.0287725 [doi] PST - epublish SO - PLoS One. 2023 Nov 16;18(11):e0287725. doi: 10.1371/journal.pone.0287725. eCollection 2023.