PMID- 37973182
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20240207
IS  - 1936-959X (Electronic)
IS  - 0195-6108 (Print)
IS  - 0195-6108 (Linking)
VI  - 44
IP  - 12
DP  - 2023 Dec 11
TI  - Diagnostic Value of Multiparameter MRI-Based Radiomics in Pediatric Myelin 
      Oligodendrocyte Glycoprotein Antibody-Associated Disorders.
PG  - 1425-1431
LID - 10.3174/ajnr.A8045 [doi]
AB  - BACKGROUND AND PURPOSE: Myelin oligodendrocyte glycoprotein antibody-associated 
      disorders (MOGAD) have a higher prevalence among children. For children 
      undergoing the initial manifestation of MOGAD, prompt diagnosis has paramount 
      importance. This study assessed the performance of multiparameter MRI-based 
      radiomics in distinguishing patients with and without MOGAD with idiopathic 
      inflammatory demyelinating diseases. MATERIALS AND METHODS: We enrolled a cohort 
      of 121 patients diagnosed with idiopathic inflammatory demyelinating diseases, 
      including 68 children with MOGAD and 53 children without MOGAD. Radiomics models 
      (T1WI, T2WI, FLAIR, and compound model) using features extracted from 
      demyelinating lesions within the brain parenchyma were developed in the training 
      set. The performance of these models underwent validation within the internal 
      testing set. Additionally, we gathered clinical factors and MRI features of brain 
      parenchymal lesions at their initial presentation. Subsequently, these variables 
      were used in the construction of a clinical prediction model through multivariate 
      logistic regression analysis. RESULTS: The areas under the curve for the 
      radiomics models (T1WI, T2WI, FLAIR, and the compound model) in the training set 
      were 0.781 (95% CI, 0.689-0.864), 0.959 (95% CI, 0.924-0.987), 0.939 (95% CI, 
      0.898-0.979), and 0.989 (95% CI, 0.976-0.999), respectively. The areas under the 
      curve for the radiomics models (T1WI, T2WI, FLAIR, and the compound model) in the 
      testing set were 0.500 (95% CI, 0.304-0.652), 0.833 (95% CI, 0.697-0.944), 0.804 
      (95% CI, 0.664-0.918), and 0.905 (95% CI, 0.803-0.979), respectively. The areas 
      under the curve of the clinical prediction model in the training set and testing 
      set were 0.700 and 0.289, respectively. CONCLUSIONS: Multiparameter MRI-based 
      radiomics helps distinguish MOGAD from non-MOGAD in patients with idiopathic 
      inflammatory demyelinating diseases.
CI  - (c) 2023 by American Journal of Neuroradiology.
FAU - Li, Ting
AU  - Li T
AUID- ORCID: 0000-0001-6943-5529
AD  - From the Department of Radiology (T.L., X.C., H.W., T.Z., L.Z., H.D., M.X., 
      L.H.), Children's Hospital of Chongqing Medical University, National Clinical 
      Research Center for Child Health and Disorders Ministry of Education Key 
      Laboratory of Child Development and Disorders, Chongqing Key Laboratory of 
      Pediatrics, Chongqing, China.
FAU - Chen, Xin
AU  - Chen X
AUID- ORCID: 0000-0001-6640-5287
AD  - From the Department of Radiology (T.L., X.C., H.W., T.Z., L.Z., H.D., M.X., 
      L.H.), Children's Hospital of Chongqing Medical University, National Clinical 
      Research Center for Child Health and Disorders Ministry of Education Key 
      Laboratory of Child Development and Disorders, Chongqing Key Laboratory of 
      Pediatrics, Chongqing, China.
FAU - Jing, Yang
AU  - Jing Y
AUID- ORCID: 0009-0002-3090-7511
AD  - Huiying Medical Technology Co (Y.J.), Dongsheng Science and Technology Park, 
      Beijing, China.
FAU - Wang, Haoru
AU  - Wang H
AUID- ORCID: 0000-0003-2497-0872
AD  - From the Department of Radiology (T.L., X.C., H.W., T.Z., L.Z., H.D., M.X., 
      L.H.), Children's Hospital of Chongqing Medical University, National Clinical 
      Research Center for Child Health and Disorders Ministry of Education Key 
      Laboratory of Child Development and Disorders, Chongqing Key Laboratory of 
      Pediatrics, Chongqing, China.
FAU - Zhang, Ting
AU  - Zhang T
AD  - From the Department of Radiology (T.L., X.C., H.W., T.Z., L.Z., H.D., M.X., 
      L.H.), Children's Hospital of Chongqing Medical University, National Clinical 
      Research Center for Child Health and Disorders Ministry of Education Key 
      Laboratory of Child Development and Disorders, Chongqing Key Laboratory of 
      Pediatrics, Chongqing, China.
FAU - Zhang, Li
AU  - Zhang L
AD  - From the Department of Radiology (T.L., X.C., H.W., T.Z., L.Z., H.D., M.X., 
      L.H.), Children's Hospital of Chongqing Medical University, National Clinical 
      Research Center for Child Health and Disorders Ministry of Education Key 
      Laboratory of Child Development and Disorders, Chongqing Key Laboratory of 
      Pediatrics, Chongqing, China.
FAU - Ding, Hao
AU  - Ding H
AD  - From the Department of Radiology (T.L., X.C., H.W., T.Z., L.Z., H.D., M.X., 
      L.H.), Children's Hospital of Chongqing Medical University, National Clinical 
      Research Center for Child Health and Disorders Ministry of Education Key 
      Laboratory of Child Development and Disorders, Chongqing Key Laboratory of 
      Pediatrics, Chongqing, China.
FAU - Xie, Mingye
AU  - Xie M
AUID- ORCID: 0009-0009-1049-5258
AD  - From the Department of Radiology (T.L., X.C., H.W., T.Z., L.Z., H.D., M.X., 
      L.H.), Children's Hospital of Chongqing Medical University, National Clinical 
      Research Center for Child Health and Disorders Ministry of Education Key 
      Laboratory of Child Development and Disorders, Chongqing Key Laboratory of 
      Pediatrics, Chongqing, China.
FAU - He, Ling
AU  - He L
AUID- ORCID: 0000-0003-2702-2579
AD  - From the Department of Radiology (T.L., X.C., H.W., T.Z., L.Z., H.D., M.X., 
      L.H.), Children's Hospital of Chongqing Medical University, National Clinical 
      Research Center for Child Health and Disorders Ministry of Education Key 
      Laboratory of Child Development and Disorders, Chongqing Key Laboratory of 
      Pediatrics, Chongqing, China doctorheling@yeah.net.
LA  - eng
PT  - Journal Article
DEP - 20231211
PL  - United States
TA  - AJNR Am J Neuroradiol
JT  - AJNR. American journal of neuroradiology
JID - 8003708
RN  - 0 (Myelin-Oligodendrocyte Glycoprotein)
SB  - IM
MH  - Humans
MH  - Child
MH  - *Models, Statistical
MH  - Myelin-Oligodendrocyte Glycoprotein
MH  - Prognosis
MH  - Magnetic Resonance Imaging
MH  - *Demyelinating Diseases/diagnostic imaging
PMC - PMC10714848
EDAT- 2023/11/17 15:31
MHDA- 2023/12/17 09:44
PMCR- 2024/12/01
CRDT- 2023/11/16 20:42
PHST- 2023/07/06 00:00 [received]
PHST- 2023/09/28 00:00 [accepted]
PHST- 2024/12/01 00:00 [pmc-release]
PHST- 2023/12/17 09:44 [medline]
PHST- 2023/11/17 15:31 [pubmed]
PHST- 2023/11/16 20:42 [entrez]
AID - ajnr.A8045 [pii]
AID - 23-00598 [pii]
AID - 10.3174/ajnr.A8045 [doi]
PST - epublish
SO  - AJNR Am J Neuroradiol. 2023 Dec 11;44(12):1425-1431. doi: 10.3174/ajnr.A8045.