PMID- 37973437
OWN - NLM
STAT- MEDLINE
DCOM- 20240401
LR  - 20240401
IS  - 1879-1476 (Electronic)
IS  - 0385-8146 (Linking)
VI  - 51
IP  - 2
DP  - 2024 Apr
TI  - New insights into chronic rhinosinusitis associated with IgG4-related disease.
PG  - 356-360
LID - S0385-8146(23)00187-6 [pii]
LID - 10.1016/j.anl.2023.10.006 [doi]
AB  - IgG4-related disease (IgG4-RD) is a chronic inflammatory disorder characterized 
      by elevated IgG4 serum levels, abundant IgG4-positive plasmacyte infiltration, 
      and fibrosis of various organs, including the head and neck. We aimed to provide 
      an overall review of IgG4-RD in the sinonasal region and propose a novel entity 
      and criteria of chronic rhinosinusitis (CRS) associated with IgG4-RD as 
      "IgG4-CRS," a distinct manifestation of IgG4-RD in the sinonasal region. 
      Sinonasal involvement has been increasingly recognized; however, this region is 
      not included in the classic IgG4-RD-affected organs. The clinical features of 
      IgG4-CRS, including its prevalence and relationship with allergies and olfactory 
      disturbances, have also been explored. Serum IgG4 levels and IgG4-positive plasma 
      cell infiltrations, crucial diagnostic factors, have been discussed in 
      association with IgG4-CRS pathogenesis. Fibrosis, a hallmark of IgG4-RD, is 
      observed in sinonasal tissues; however, typical fibrosis, such as storiform 
      fibrosis, is not usually found. Mimics or complications in eosinophilic CRS 
      (ECRS) and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) are 
      highlighted. Treatment often involves typically effective glucocorticoids. 
      Organ-specific diagnostic criteria for the sinonasal region have not currently 
      been established. Hence, this review aims to foster awareness and understanding 
      of IgG4-CRS among ENT physicians and to provide a basis for future research and 
      diagnostic refinement.
CI  - Copyright (c) 2023. Published by Elsevier B.V.
FAU - Takano, Kenichi
AU  - Takano K
AD  - Department of Otolaryngology-Head and Neck Surgery, Sapporo Medical University 
      School of Medicine, S1W17, Chuo-ku, Sapporo 060-8556, Japan. Electronic address: 
      kent@sapmed.ac.jp.
FAU - Kamekura, Ryuta
AU  - Kamekura R
AD  - Department of Otolaryngology-Head and Neck Surgery, Sapporo Medical University 
      School of Medicine, S1W17, Chuo-ku, Sapporo 060-8556, Japan.
FAU - Okuni, Tsuyoshi
AU  - Okuni T
AD  - Department of Otolaryngology-Head and Neck Surgery, Sapporo Medical University 
      School of Medicine, S1W17, Chuo-ku, Sapporo 060-8556, Japan.
FAU - Yamamoto, Keisuke
AU  - Yamamoto K
AD  - Department of Otolaryngology-Head and Neck Surgery, Sapporo Medical University 
      School of Medicine, S1W17, Chuo-ku, Sapporo 060-8556, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231114
PL  - Netherlands
TA  - Auris Nasus Larynx
JT  - Auris, nasus, larynx
JID - 7708170
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Humans
MH  - *Immunoglobulin G4-Related Disease/complications/diagnosis
MH  - *Rhinosinusitis
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - Immunoglobulin G
MH  - *Sinusitis/complications
MH  - Fibrosis
MH  - Chronic Disease
OTO - NOTNLM
OT  - Chronic rhinosinusitis
OT  - IgG4
OT  - IgG4-related disease
OT  - Review
COIS- Declaration of Competing Interest The authors declare no conflicts of interest 
      associated with this manuscript.
EDAT- 2023/11/17 15:26
MHDA- 2024/04/01 06:42
CRDT- 2023/11/16 21:57
PHST- 2023/08/24 00:00 [received]
PHST- 2023/10/23 00:00 [revised]
PHST- 2023/10/25 00:00 [accepted]
PHST- 2024/04/01 06:42 [medline]
PHST- 2023/11/17 15:26 [pubmed]
PHST- 2023/11/16 21:57 [entrez]
AID - S0385-8146(23)00187-6 [pii]
AID - 10.1016/j.anl.2023.10.006 [doi]
PST - ppublish
SO  - Auris Nasus Larynx. 2024 Apr;51(2):356-360. doi: 10.1016/j.anl.2023.10.006. Epub 
      2023 Nov 14.