PMID- 37975099
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231118
IS  - 2251-6581 (Print)
IS  - 2251-6581 (Electronic)
IS  - 2251-6581 (Linking)
VI  - 22
IP  - 2
DP  - 2023 Dec
TI  - A comprehensive review on the risks assessment and treatment options for 
      Sarcopenia in people with diabetes.
PG  - 995-1010
LID - 10.1007/s40200-023-01262-w [doi]
AB  - OBJECTIVES: This comprehensive review aims to examine the reciprocal interplay 
      between Type 2 diabetes mellitus (T2DM) and sarcopenia, identify prevailing 
      research gaps, and discuss therapeutic approaches and measures to enhance 
      healthcare practices within hospital settings. METHODS: A thorough literature 
      review was conducted to gather relevant studies and articles on the relationship 
      between T2DM and sarcopenia. Various databases were searched, including Google 
      Scholar, PubMed, Scopus, and Science Direct databases. The search terms included 
      T2DM, sarcopenia, inflammation, insulin resistance, advanced glycation end 
      products, oxidative stress, muscle dimensions, muscle strength, muscle 
      performance, aging, nutrition, hormone levels, and physical activity. The 
      collected articles were critically analysed to extract key findings and identify 
      gaps in current research. RESULTS: The prevalence and incidence of metabolic and 
      musculoskeletal disorders, notably T2DM and sarcopenia, have surged in recent 
      years. T2DM is marked by inflammation, insulin resistance, accumulation of 
      advanced glycation end products, and oxidative stress, while sarcopenia involves 
      a progressive decline in skeletal muscle mass and function. The review 
      underscores the age-related correlation between sarcopenia and adverse outcomes 
      like fractures, falls, and mortality. Research gaps regarding optimal nutritional 
      interventions for individuals with T2DM and sarcopenia are identified, 
      emphasizing the necessity for further investigation in this area. CONCLUSIONS: 
      The reciprocal interplay between T2DM and sarcopenia holds significant 
      importance. Further research is warranted to address knowledge gaps, particularly 
      in utilizing precise measurement tools during clinical trials. Lifestyle 
      modifications appear beneficial for individuals with T2DM and sarcopenia. 
      Additionally, practical nutritional interventions require investigation to 
      optimize healthcare practices in hospital settings. SUPPLEMENTARY INFORMATION: 
      The online version contains supplementary material available at 
      10.1007/s40200-023-01262-w.
CI  - (c) The Author(s), under exclusive licence to Tehran University of Medical Sciences 
      2023. Springer Nature or its licensor (e.g. a society or other partner) holds 
      exclusive rights to this article under a publishing agreement with the author(s) 
      or other rightsholder(s); author self-archiving of the accepted manuscript 
      version of this article is solely governed by the terms of such publishing 
      agreement and applicable law.
FAU - Johri, Nishant
AU  - Johri N
AUID- ORCID: 0000-0002-9212-6043
AD  - Department of Pharmacy Practice, Teerthanker Mahaveer College of Pharmacy, 
      Moradabad, Uttar Pradesh India.
FAU - Vengat, Maheshwari
AU  - Vengat M
AD  - Department of Oncology, University of Chester, Chester, UK. ROR: 
      https://ror.org/01drpwb22. GRID: grid.43710.31. ISNI: 0000 0001 0683 9016
FAU - Kumar, Deepanshu
AU  - Kumar D
AD  - Department of Pharmacy Practice, Teerthanker Mahaveer College of Pharmacy, 
      Moradabad, Uttar Pradesh India.
FAU - Nagar, Priya
AU  - Nagar P
AD  - Department of Pharmacy Practice, Teerthanker Mahaveer College of Pharmacy, 
      Moradabad, Uttar Pradesh India.
FAU - John, Davis
AU  - John D
AD  - Department of Pharmacy Practice, Teerthanker Mahaveer College of Pharmacy, 
      Moradabad, Uttar Pradesh India.
FAU - Dutta, Shubham
AU  - Dutta S
AD  - Department of Pharmacy Practice, Teerthanker Mahaveer College of Pharmacy, 
      Moradabad, Uttar Pradesh India.
FAU - Mittal, Piyush
AU  - Mittal P
AD  - Department of Pharmacy Practice, Teerthanker Mahaveer College of Pharmacy, 
      Moradabad, Uttar Pradesh India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230730
PL  - Switzerland
TA  - J Diabetes Metab Disord
JT  - Journal of diabetes and metabolic disorders
JID - 101590741
PMC - PMC10638272
OTO - NOTNLM
OT  - Health metabolic health
OT  - Muscle
OT  - Obesity
OT  - Sarcopenia
OT  - T2DM
COIS- This paper is devoid of any conflict of interest.
EDAT- 2023/11/17 15:25
MHDA- 2023/11/17 15:26
PMCR- 2024/07/30
CRDT- 2023/11/17 03:57
PHST- 2023/03/24 00:00 [received]
PHST- 2023/07/03 00:00 [accepted]
PHST- 2024/07/30 00:00 [pmc-release]
PHST- 2023/11/17 15:26 [medline]
PHST- 2023/11/17 15:25 [pubmed]
PHST- 2023/11/17 03:57 [entrez]
AID - 1262 [pii]
AID - 10.1007/s40200-023-01262-w [doi]
PST - epublish
SO  - J Diabetes Metab Disord. 2023 Jul 30;22(2):995-1010. doi: 
      10.1007/s40200-023-01262-w. eCollection 2023 Dec.