PMID- 37975111
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231118
IS  - 2251-6581 (Print)
IS  - 2251-6581 (Electronic)
IS  - 2251-6581 (Linking)
VI  - 22
IP  - 2
DP  - 2023 Dec
TI  - Association between type 2 diabetes and branched chain amino acids (BCAA); a 
      case-control study.
PG  - 1291-1297
LID - 10.1007/s40200-023-01247-9 [doi]
AB  - BACKGROUND: Several amino acids and their derivatives have been implicated in 
      insulin resistance (IR) and Type 2 Diabetes Mellitus (T2DM). This research sought 
      to establish a relationship between the dietary levels of branched-chain amino 
      acids (BCAA) and the risk of T2DM. METHODS: This case-control study was carried 
      out on 4200 participants consisting of 589 people with T2DM and 3611 non-diabetic 
      aged 35 to 70 years residents in Sabzevar, Iran. Data on the economic-social, 
      employment status, medical history, lifestyle, and sleep habits were collected 
      via interview. The food frequency questionnaire (FFQ) was used to check the 
      nutritional status. Participants' dietary BCAA consumption was estimated using 
      Nutritionist IV software. RESULTS: A significant negative association between the 
      incidence of T2DM and the dietary levels of BCAAs after adjustment for age and 
      sex (OR = 0.972, CI 95%:0.648-0.996, P = 0.022). The negative association 
      remained significant after additional adjustments for body mass index (BMI) and 
      physical activity (OR = 0.967, CI 95%: 0.943-0.992, P = 0.010). Interestingly, a 
      positive association was found between T2DM and total BCAAs (OR = 1.067, CI 95%: 
      1.017-1.119, P = 0.008), Isoleucine (OR = 1.248, CI 95%: 1.043-1.494, P = 0.016), 
      Leucine (OR = 1.165, CI 95%: 1.046-1.299, P = 0.006) and Valine (OR = 1.274, CI 
      95%: 1.088-1.492, P = 0.003) after further adjustment for calorie intake. 
      CONCLUSIONS: Our results demonstrate branched-chain amino acids (BCAAs) including 
      isoleucine, leucine, and valine are negatively associated with the incidence of 
      type 2 diabetes (T2DM) after adjusting for age and sex, BMI, and physical 
      activity. However, adjusting for calorie intake reversed the association between 
      T2DM and BCAAs. These findings suggest that the association between BCAAs and 
      T2DM may be influenced by calorie intake. Future longitudinal studies are 
      warranted. SUPPLEMENTARY INFORMATION: The online version contains supplementary 
      material available at 10.1007/s40200-023-01247-9.
CI  - (c) The Author(s), under exclusive licence to Tehran University of Medical Sciences 
      2023. Springer Nature or its licensor (e.g. a society or other partner) holds 
      exclusive rights to this article under a publishing agreement with the author(s) 
      or other rightsholder(s); author self-archiving of the accepted manuscript 
      version of this article is solely governed by the terms of such publishing 
      agreement and applicable law.
FAU - Torki, Saheb Abbas
AU  - Torki SA
AD  - Department of Nutrition, Faculty of Nutrition Sciences, Shiraz University of 
      Medical Sciences, Shiraz, Iran. ROR: https://ror.org/01n3s4692. GRID: 
      grid.412571.4. ISNI: 0000 0000 8819 4698
FAU - Bahadori, Effat
AU  - Bahadori E
AD  - Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran. 
      ROR: https://ror.org/04sfka033. GRID: grid.411583.a. ISNI: 0000 0001 2198 6209
FAU - Aghakhaninejad, Zohreh
AU  - Aghakhaninejad Z
AD  - Department of Nutrition, Faculty of Public Health, Kerman University of Medical 
      Sciences, Kerman, Iran. ROR: https://ror.org/02kxbqc24. GRID: grid.412105.3. 
      ISNI: 0000 0001 2092 9755
FAU - Mohseni, Golsa Khalatbari
AU  - Mohseni GK
AD  - Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of 
      Medical Sciences, Ahvaz, Iran. ROR: https://ror.org/01rws6r75. GRID: 
      grid.411230.5. ISNI: 0000 0000 9296 6873
FAU - Tajadod, Shirin
AU  - Tajadod S
AD  - Department of Nutrition, School of Public Health, International Campus, Iran 
      University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/03w04rv71. 
      GRID: grid.411746.1. ISNI: 0000 0004 4911 7066
FAU - Rajabi Harsini, Asma
AU  - Rajabi Harsini A
AD  - Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran. ROR: 
      https://ror.org/01c4pz451. GRID: grid.411705.6. ISNI: 0000 0001 0166 0922
FAU - Azaryan, Fatemeh
AU  - Azaryan F
AD  - Department of Physiology, School of Medicine, Zahedan University of Medical 
      Sciences, Zahedan, Iran. ROR: https://ror.org/03r42d171. GRID: grid.488433.0. 
      ISNI: 0000 0004 0612 8339
FAU - Saeedirad, Zahra
AU  - Saeedirad Z
AD  - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food 
      Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ROR: 
      https://ror.org/034m2b326. GRID: grid.411600.2
FAU - Askarpour, Seyed Ali
AU  - Askarpour SA
AD  - Division of Food Safety and Hygiene, Department of Environmental Health 
      Engineering, School of Public Health, Tehran University of Medical Sciences, 
      Tehran, Iran. ROR: https://ror.org/01c4pz451. GRID: grid.411705.6. ISNI: 0000 
      0001 0166 0922
FAU - Mahmoudi, Zahra
AU  - Mahmoudi Z
AD  - Department of Nutrition, Science and Research Branch, Islamic Azad University, 
      Tehran, Iran. GRID: grid.411463.5. ISNI: 0000 0001 0706 2472
FAU - Khoshdooz, Sara
AU  - Khoshdooz S
AD  - Guilan University of Medical Sciences, Rasht, Iran. GRID: grid.411874.f. ISNI: 
      0000 0004 0571 1549
FAU - Bahar, Bojlul
AU  - Bahar B
AD  - Nutrition Sciences and Applied Food Safety Studies, Research Centre for Global 
      Development, School of Sport and Health Sciences, University of Central 
      Lancashire, Preston, UK. ROR: https://ror.org/010jbqd54. GRID: grid.7943.9. ISNI: 
      0000 0001 2167 3843
FAU - Shafaei, Hanieh
AU  - Shafaei H
AD  - Nursing and Midwifery School, Guilan University of Medical Sciences, Rasht, Iran. 
      GRID: grid.411874.f. ISNI: 0000 0004 0571 1549
FAU - Mosavi Jarrahi, Seyed Alireza
AU  - Mosavi Jarrahi SA
AD  - School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 
      ROR: https://ror.org/034m2b326. GRID: grid.411600.2
FAU - Doaei, Saeid
AU  - Doaei S
AD  - Department of Community Nutrition, Faculty of Nutrition Sciences and Food 
      Technology, National Nutrition and Food Technology Research Institute, Shahid 
      Beheshti University of Medical Sciences, Tehran, Iran. GRID: grid.411600.2
FAU - Nazemi, Samad
AU  - Nazemi S
AD  - Cellular and Molecular Research Center, Department of Physiology and 
      Pharmacology, Sabzevar University of Medical Science, Sabzevar, Iran. ROR: 
      https://ror.org/05tgdvt16. GRID: grid.412328.e. ISNI: 0000 0004 0610 7204
FAU - Gholamalizadeh, Maryam
AU  - Gholamalizadeh M
AD  - Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 
      Iran. ROR: https://ror.org/034m2b326. GRID: grid.411600.2
LA  - eng
PT  - Journal Article
DEP - 20230722
PL  - Switzerland
TA  - J Diabetes Metab Disord
JT  - Journal of diabetes and metabolic disorders
JID - 101590741
PMC - PMC10638320
OTO - NOTNLM
OT  - Branched-chain amino acids
OT  - Dietary intake
OT  - Type 2 diabetes mellitus
COIS- Competing interestsThe authors declare that they have no competing interests.
EDAT- 2023/11/17 15:32
MHDA- 2023/11/17 15:33
PMCR- 2024/07/22
CRDT- 2023/11/17 03:57
PHST- 2023/04/16 00:00 [received]
PHST- 2023/06/03 00:00 [accepted]
PHST- 2024/07/22 00:00 [pmc-release]
PHST- 2023/11/17 15:33 [medline]
PHST- 2023/11/17 15:32 [pubmed]
PHST- 2023/11/17 03:57 [entrez]
AID - 1247 [pii]
AID - 10.1007/s40200-023-01247-9 [doi]
PST - epublish
SO  - J Diabetes Metab Disord. 2023 Jul 22;22(2):1291-1297. doi: 
      10.1007/s40200-023-01247-9. eCollection 2023 Dec.