PMID- 37975383
OWN - NLM
STAT- MEDLINE
DCOM- 20231120
LR  - 20231120
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 27
IP  - 21
DP  - 2023 Nov
TI  - New approaches in the diagnosis and prognosis of gestational diabetes mellitus.
PG  - 10583-10594
LID - 34338 [pii]
LID - 10.26355/eurrev_202311_34338 [doi]
AB  - Gestational diabetes mellitus (GDM) is the most common pregnancy metabolic 
      disorder in which a person with no history of hyperglycemia exhibits any degree 
      of impaired glucose tolerance during gestation. GDM can be resolved on its own 
      after birth, but mothers with GDM are more at risk for future problems, such as 
      type 2 diabetes, obesity, and cardiovascular disease. In addition, GDM can cause 
      macrosomia in infants and obesity or even the risk of diabetes in childhood. 
      Standard diagnostic tests for GDM are the oral glucose tolerance test (OGTT) and 
      glucose challenge test (GCT), which is a mandatory test at 28-28 weeks of 
      pregnancy in most countries. Disorders in various molecular mechanisms, such as 
      hepatocyte growth factor (HGF), mechanistic target of rapamycin (mTOR), and 
      nuclear factor-kappaB (NF-kappaB) signaling pathways are involved in GDM. Therefore, 
      a better understanding of these mechanisms can help find new therapeutic and 
      diagnostic strategies accordingly. In this review, we first deal with molecular 
      mechanisms involved in GDM occurrence and then summarized the studies that hired 
      this knowledge for early diagnosis and prognosis of GDM. Finally, we present the 
      latest achievements in the diagnosis of GDM based on exosomes, microRNAs, 
      glycosylated hemoglobin, and inflammatory factors detection in maternal 
      circulation.
FAU - Gu, Z-J
AU  - Gu ZJ
AD  - Department of Obstetrics and Gynaecology, Taicang TCM Hospital Affiliated to 
      Nanjing University of Chinese Medicine, Taicang, China. fsyy00946@njucm.edu.cn.
FAU - Song, Q-J
AU  - Song QJ
FAU - Gu, W-Q
AU  - Gu WQ
FAU - Zhang, G-P
AU  - Zhang GP
FAU - Su, Y
AU  - Su Y
FAU - Tang, Y
AU  - Tang Y
FAU - Wang, M-F
AU  - Wang MF
FAU - Guo, Y
AU  - Guo Y
FAU - Wu, W-M
AU  - Wu WM
FAU - Chen, J
AU  - Chen J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - *Diabetes, Gestational/diagnosis
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Fetal Macrosomia
MH  - Prognosis
MH  - Obesity/complications
MH  - Blood Glucose/metabolism
EDAT- 2023/11/17 15:27
MHDA- 2023/11/20 06:54
CRDT- 2023/11/17 06:33
PHST- 2023/11/20 06:54 [medline]
PHST- 2023/11/17 15:27 [pubmed]
PHST- 2023/11/17 06:33 [entrez]
AID - 34338 [pii]
AID - 10.26355/eurrev_202311_34338 [doi]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2023 Nov;27(21):10583-10594. doi: 
      10.26355/eurrev_202311_34338.