PMID- 37976296 OWN - NLM STAT- MEDLINE DCOM- 20231120 LR - 20231124 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 18 IP - 11 DP - 2023 TI - Lower odds of COVID-19-related mortality in hospitalised patients with type II diabetes mellitus: A single-centre study. PG - e0287968 LID - 10.1371/journal.pone.0287968 [doi] LID - e0287968 AB - BACKGROUND: COVID-19 infection in patients with type 2 diabetes mellitus (T2DM) -a chronic illness in Lebanon-is not well described. METHODS: This was a single-centre retrospective observational study of 491 patients, including 152 patients with T2DM, who were hospitalised for COVID-19 between 20 August 2020 and 21 April 2021. Data on clinical characteristics, laboratory and radiological findings and outcomes were collected from the electronic medical records. Clinical characteristics and in-hospital mortality between patients with and without T2DM infected with COVID-19 using multivariate analysis were compared. RESULTS: Patients with T2DM were significantly older than those without T2DM (mean age, 68.7 vs. 60.3 years). Patients with T2DM were more likely to present with a body temperature of <38.3 degrees C (83.9% vs. 69.9%) and less likely to present with chest pain (3.9% vs. 9.1%) and sore throat (2.0% vs. 6.8%). Patients with T2DM were more likely to be hypertensive (76.35% vs. 41%) and dyslipidaemic (58.6% vs. 25.7%) and had more frequent underlying coronary artery disease (33.6% vs. 12.4%). The rates of patients with creatinine levels of >/=1.17 mg/L and troponin T levels of >/=4 ng/dL were higher in the T2DM group than in the non-T2DM group (30.4% vs. 15% and 93.3% vs. 83.1%, respectively). Patients with T2DM were more likely to be admitted to the intensive care unit (ICU) (34.2% vs. 22.1%), require invasive ventilation (18.4% vs. 10.3%) and receive vasopressors (16.4% vs. 10.0%). Increasing age and the use of invasive ventilation and vasopressors were associated with higher odds of mortality (odds ratio (OR), 1.08, 9.95 and 19.83, respectively), whereas longer ICU stay was associated with lower odds of mortality (OR, 0.38). The odds of mortality were lower in the T2DM group than in the non-T2DM group (OR, 0.27). CONCLUSION: Among patients hospitalised for COVID-19, those with T2DM were older, presented with milder symptoms and had more comorbidities and higher troponin T levels compared with those without T2DM. Despite the worse clinical course, the patients with T2DM had lower odds of mortality than those without T2DM. CI - Copyright: (c) 2023 Mina et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Mina, Jonathan AU - Mina J AD - Department of Internal Medicine, Staten Island University Hospital, Staten Island, New York, United States of America. FAU - Samaha, Nadia L AU - Samaha NL AD - Georgetown University School of Medicine, Washington, D.C., United States of America. FAU - Fleifel, Mohamad AU - Fleifel M AD - Department of Internal Medicine, Lebanese American University Medical Centre-Rizk Hospital, Beirut, Lebanon. AD - Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon. FAU - Nasr, Janane AU - Nasr J AD - Department of Internal Medicine, Lebanese American University Medical Centre-Rizk Hospital, Beirut, Lebanon. AD - Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon. FAU - Haykal, Tony AU - Haykal T AUID- ORCID: 0000-0002-0475-4833 AD - Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon. FAU - Dimassi, Hani AU - Dimassi H AD - School of Pharmacy, Lebanese American University, Byblos, Lebanon. FAU - Harb, Ranime AU - Harb R AD - School of Pharmacy, Lebanese American University, Byblos, Lebanon. FAU - Hout, Ghida El AU - Hout GE AD - Department of Internal Medicine, Lebanese American University Medical Centre-Rizk Hospital, Beirut, Lebanon. FAU - Franjieh, Elissar AU - Franjieh E AD - Department of Internal Medicine, Lebanese American University Medical Centre-Rizk Hospital, Beirut, Lebanon. FAU - Mahdi, Ahmad AU - Mahdi A AD - Department of Internal Medicine, Lebanese American University Medical Centre-Rizk Hospital, Beirut, Lebanon. AD - Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon. FAU - Mokhbat, Jacques AU - Mokhbat J AD - Department of Internal Medicine, Lebanese American University Medical Centre-Rizk Hospital, Beirut, Lebanon. FAU - Farra, Anna AU - Farra A AUID- ORCID: 0000-0001-5892-7608 AD - Department of Internal Medicine, Lebanese American University Medical Centre-Rizk Hospital, Beirut, Lebanon. FAU - Husni, Rola AU - Husni R AUID- ORCID: 0000-0002-6893-5027 AD - Department of Internal Medicine, Lebanese American University Medical Centre-Rizk Hospital, Beirut, Lebanon. AD - Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon. LA - eng PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20231117 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Troponin T) SB - IM MH - Humans MH - Aged MH - *COVID-19 MH - *Diabetes Mellitus, Type 2/complications MH - SARS-CoV-2 MH - Troponin T MH - Hospitalization MH - Retrospective Studies MH - Intensive Care Units PMC - PMC10656017 COIS- The authors have declared that no competing interests exist. EDAT- 2023/11/17 18:42 MHDA- 2023/11/20 06:54 PMCR- 2023/11/17 CRDT- 2023/11/17 13:35 PHST- 2022/08/05 00:00 [received] PHST- 2023/06/01 00:00 [accepted] PHST- 2023/11/20 06:54 [medline] PHST- 2023/11/17 18:42 [pubmed] PHST- 2023/11/17 13:35 [entrez] PHST- 2023/11/17 00:00 [pmc-release] AID - PONE-D-22-21960 [pii] AID - 10.1371/journal.pone.0287968 [doi] PST - epublish SO - PLoS One. 2023 Nov 17;18(11):e0287968. doi: 10.1371/journal.pone.0287968. eCollection 2023.