PMID- 37977273
OWN - NLM
STAT- MEDLINE
DCOM- 20240105
LR  - 20240116
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 241
DP  - 2024 Jan 15
TI  - Placental concentrations of xenoestrogenic organochlorine pesticides and 
      polychlorinated biphenyls and assessment of their xenoestrogenicity in the 
      PA-MAMI mother-child cohort.
PG  - 117622
LID - S0013-9351(23)02426-X [pii]
LID - 10.1016/j.envres.2023.117622 [doi]
AB  - BACKGROUND: Organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCB), 
      they have contributed to the exposure of women to persistent organic pollutants 
      (POPs). These compounds can cross the placental barrier and interfere with the 
      hormonal system of newborns. AIM: To determine concentrations of OCPs and PCBs 
      and their xenoestrogenic activity in placentas of women from the PA-MAMI cohort 
      of Panama. METHODS: Thirty-nine placenta samples from women in the Azuero 
      peninsula (Panama) were analyzed. Five OCPs 
      [p-p'-dichlorodiphenyldichloroethylene (p-p'-DDE), beta-hexachlorohexane (beta-HCH), 
      gamma-hexachlorohexane (lindane), hexachlorobenzene (HCB) and mirex] and three PCB 
      congeners (PCB-138, PCB-153 and PCB-180) were quantified in placenta extracts. 
      The xenoestrogenic activity of extracts was assessed with the E-Screen bioassay 
      to estimate the total effective xenoestrogen burden (TEXB). RESULTS: All 
      placental samples were positive for at least three POP residues and >70% for at 
      least six. The frequencies of quantified OCPs ranged from 100% for p,p'-DDE and 
      HCB to 30.8% for beta-HCH. The highest median concentration was for lindane 
      (380.0 pg/g placenta), followed by p,p'-DDE (280.0 pg/g placenta), and HCB 
      (90.0 pg/g placenta). Exposure to p,p'-DDE was associated with greater meat 
      consumption, suggesting that animal fat is a major source of exposure to DDT 
      metabolites. The frequency of detected PCBs ranged between 70 and 90%; the 
      highest median concentration was for PCB 138 (17.0 pg/g placenta), followed by 
      PCB 153 (16.0 pg/g placenta). All placentas were positive in the estrogenicity 
      bioassay with a median TEXB-alpha of 0.91 pM Eeq/g of placenta. Exposure to lindane 
      was positively associated with the xenoestrogenicity of TEXB- alpha, whereas this 
      association was negative in the case of exposure to PCB 153. CONCLUSIONS: To our 
      best knowledge, this study contributes the first evidence on the presence of POPs 
      and xenoestrogenic burden in placentas from Latin-American women. Given concerns 
      about the consequences of prenatal exposure to these compounds on children's 
      health, preventive measures are highly recommended to eliminate or minimize the 
      risk of OCP exposure during pregnancy.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Iribarne-Duran, L M
AU  - Iribarne-Duran LM
AD  - Instituto de Investigacion Biosanitaria de Granada (ibs. GRANADA), E-18012, 
      Granada, Spain. Electronic address: luzmaria.irdu@gmail.com.
FAU - Castillero-Rosales, I
AU  - Castillero-Rosales I
AD  - Departamento de Quimica Analitica, FCNET, Universidad de Panama, Panama.
FAU - Peinado, F M
AU  - Peinado FM
AD  - Instituto de Investigacion Biosanitaria de Granada (ibs. GRANADA), E-18012, 
      Granada, Spain.
FAU - Artacho-Cordon, F
AU  - Artacho-Cordon F
AD  - Instituto de Investigacion Biosanitaria de Granada (ibs. GRANADA), E-18012, 
      Granada, Spain; CIBER de Epidemiologia y Salud Publica (CIBERESP), E- 28029, 
      Madrid, Spain; Departamento de Radiologia y Medicina Fisica, Universidad de 
      Granada, E- 18016, Granada, Spain.
FAU - Molina-Molina, J M
AU  - Molina-Molina JM
AD  - Instituto de Investigacion Biosanitaria de Granada (ibs. GRANADA), E-18012, 
      Granada, Spain.
FAU - Medianero, E
AU  - Medianero E
AD  - Departamento de Ciencias Ambientales, Facultad de Ciencias Naturales, Exactas y 
      Tecnologia, Universidad de Panama, Panama; Secretaria Nacional de Ciencia, 
      Tecnologia e Innovacion (SENACYT), Panama.
FAU - Nicolas-Delgado, S I
AU  - Nicolas-Delgado SI
AD  - Departamento de Ginecologia y Obstetricia, Hospital Joaquin Pablo Franco Sayas, 
      Ministerio de Salud, Los Santos, Panama.
FAU - Sanchez-Pinzon, L
AU  - Sanchez-Pinzon L
AD  - Clinica de Cesacion de Tabaco y Clinica del Empleado Local, Region de Salud de 
      Azuero, Ministerio de Salud, Los Santos, Panama.
FAU - Nunez-Samudio, V
AU  - Nunez-Samudio V
AD  - Departamento de Salud Publica, Seccion de Epidemiologia, Region de Salud de 
      Herrera, Ministerio de Salud, Panama; Instituto de Ciencias Medicas, Las Tablas, 
      Los Santos, Panama.
FAU - Vela-Soria, F
AU  - Vela-Soria F
AD  - Instituto de Investigacion Biosanitaria de Granada (ibs. GRANADA), E-18012, 
      Granada, Spain.
FAU - Olea, N
AU  - Olea N
AD  - Instituto de Investigacion Biosanitaria de Granada (ibs. GRANADA), E-18012, 
      Granada, Spain; CIBER de Epidemiologia y Salud Publica (CIBERESP), E- 28029, 
      Madrid, Spain; Departamento de Radiologia y Medicina Fisica, Universidad de 
      Granada, E- 18016, Granada, Spain; Unidad de Medicina Nuclear, Hospital 
      Universitario San Cecilio, E- 18016, Granada, Spain.
FAU - Alvarado-Gonzalez, N E
AU  - Alvarado-Gonzalez NE
AD  - Instituto Especializado de Analisis (IEA), Vicerrectoria de Investigacion y 
      Postgrado, Universidad de Panama, Panama.
LA  - eng
PT  - Journal Article
DEP - 20231115
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - ZRU0C9E32O (2,4,5,2',4',5'-hexachlorobiphenyl)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - YM80ODM9PD (beta-hexachlorocyclohexane)
RN  - 59NEE7PCAB (Hexachlorocyclohexane)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
RN  - CIW5S16655 (DDT)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Infant, Newborn
MH  - Animals
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - *Polychlorinated Biphenyls/analysis
MH  - Hexachlorocyclohexane/analysis/metabolism
MH  - Dichlorodiphenyl Dichloroethylene
MH  - Hexachlorobenzene/analysis
MH  - DDT/analysis
MH  - Placenta/chemistry
MH  - *Hydrocarbons, Chlorinated/analysis
MH  - *Pesticides/analysis
MH  - *Environmental Pollutants/analysis
MH  - Mother-Child Relations
OTO - NOTNLM
OT  - Organochlorines
OT  - TEXB
OT  - Women
OT  - Xenoestrogens
OT  - placenta
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/11/18 11:41
MHDA- 2024/01/05 06:43
CRDT- 2023/11/17 19:35
PHST- 2023/04/26 00:00 [received]
PHST- 2023/11/05 00:00 [revised]
PHST- 2023/11/07 00:00 [accepted]
PHST- 2024/01/05 06:43 [medline]
PHST- 2023/11/18 11:41 [pubmed]
PHST- 2023/11/17 19:35 [entrez]
AID - S0013-9351(23)02426-X [pii]
AID - 10.1016/j.envres.2023.117622 [doi]
PST - ppublish
SO  - Environ Res. 2024 Jan 15;241:117622. doi: 10.1016/j.envres.2023.117622. Epub 2023 
      Nov 15.