PMID- 37977557
OWN - NLM
STAT- MEDLINE
DCOM- 20240122
LR  - 20240201
IS  - 1439-3646 (Electronic)
IS  - 0947-7349 (Linking)
VI  - 132
IP  - 1
DP  - 2024 Jan
TI  - Is There A Connection Between Primary Hypophysitis and Celiac Disease?
PG  - 33-38
LID - 10.1055/a-2213-4375 [doi]
AB  - AIM: To investigate the autoimmune and genetic relationship between primary 
      hypophysitis (PH) and celiac disease (CD). METHODS: The study was retrospective 
      and patients with PH followed in our clinic between 2007 and 2022 were evaluated. 
      Clinical, endocrinologic, pathologic, and radiologic findings and treatment 
      modalities were assessed. Patients diagnosed with CD in the Gastroenterology 
      outpatient clinic in 2020-2022 were included in the study as a control group. 
      Information such as sociodemographic data, year of diagnosis, human leukocyte 
      antigen (HLA) DQ2/8 information, CD-specific antibody levels, pathologic results 
      of duodenal biopsy, treatment received, follow-up status, additional diseases, 
      hormone use, and surgical history was obtained from patient records at PH.In 
      patients diagnosed with PH, a duodenal biopsy was obtained, and the tissue was 
      examined for CD by experienced pathologists. Anti-pituitary antibody (APA) and 
      anti-arginine-vasopressin (AAVP) antibody levels of individuals with PH and CD 
      were measured. RESULTS: The study included 19 patients with lymphocytic 
      hypophysitis, 30 celiac patients, and 30 healthy controls. When patients 
      diagnosed with lymphocytic hypophysitis were examined by duodenal biopsy, no 
      evidence of CD was found in the pathologic findings. The detection rate of 
      HLA-DQ2/8 was 80% in celiac patients and 42% in PH (p=0.044). (APA and AAVP 
      antibodies associated with PH were tested in two separate groups of patients and 
      in the control group. APA and anti-arginine vasopressin (AAVP) levels in PH, CD 
      and healthy controls, respectively M [IQR]: 542 [178-607];164 [125-243]; 82 
      [74-107] ng/dL (p=0.001), 174 [52-218]; 60 [47-82]; 59 [48-76] ng/dL (p=0.008) 
      were detected. The presence of an HLA-DQ2/8 haplotype correlates with posterior 
      hypophysitis and panhypophysitis (r=0.598, p=0.04 and r=0.657, p=0.02, 
      respectively). CONCLUSION: Although patients with PH were found to have 
      significant levels of HLA-DQ2/8, no CD was found in the tissue. Higher levels of 
      pituitary antibodies were detected in celiac patients compared with healthy 
      controls, but no hypophysitis clinic was observed at follow-up. Although these 
      findings suggest that the two diseases may share a common genetic and autoimmune 
      basis, the development of the disease may be partially explained by exposure to 
      environmental factors.
CI  - Thieme. All rights reserved.
FAU - Kara, Zehra
AU  - Kara Z
AD  - Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of 
      Endocrinology, Metabolism, and Diabetes, Istanbul, Turkey.
FAU - Eskazan, Tugce
AU  - Eskazan T
AD  - Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of 
      Gastroenterology and Hepatology, Istanbul, Turkey.
FAU - Sahin, Serdar
AU  - Sahin S
AD  - Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of 
      Endocrinology, Metabolism, and Diabetes, Istanbul, Turkey.
FAU - Durcan, Emre
AU  - Durcan E
AD  - Bagcilar Training and Research Hospital, Department of Endocrinology, Metabolism, 
      and Diabetes, Istanbul, Turkey.
FAU - Sulu, Cem
AU  - Sulu C
AD  - Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of 
      Endocrinology, Metabolism, and Diabetes, Istanbul, Turkey.
FAU - Demir, Ahmet Numan
AU  - Demir AN
AD  - Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of 
      Endocrinology, Metabolism, and Diabetes, Istanbul, Turkey.
FAU - Uysal, Serhat
AU  - Uysal S
AD  - Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of 
      Endocrinology, Metabolism, and Diabetes, Istanbul, Turkey.
FAU - Ozkaya, Hande Mefkure
AU  - Ozkaya HM
AD  - Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of 
      Endocrinology, Metabolism, and Diabetes, Istanbul, Turkey.
FAU - Yilmaz, Erkan
AU  - Yilmaz E
AD  - Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Organ 
      Transplantation, HLA Laboratory, Istanbul, Turkey.
FAU - Hatemi, Ali Ibrahim
AU  - Hatemi AI
AD  - Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of 
      Gastroenterology and Hepatology, Istanbul, Turkey.
FAU - Bolayirli, Ibrahim Murat
AU  - Bolayirli IM
AD  - Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of 
      Biochemistry, Istanbul, Turkey.
FAU - Kadioglu, Pinar
AU  - Kadioglu P
AUID- ORCID: 0000-0002-8329-140X
AD  - Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of 
      Endocrinology, Metabolism, and Diabetes, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20231117
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
RN  - 11000-17-2 (Vasopressins)
SB  - IM
MH  - Humans
MH  - *Celiac Disease/complications/diagnosis
MH  - Retrospective Studies
MH  - *Autoimmune Hypophysitis/complications
MH  - Haplotypes
MH  - Vasopressins/genetics
COIS- The authors have no conflicts of interest to declare.
EDAT- 2023/11/18 11:41
MHDA- 2024/01/22 06:42
CRDT- 2023/11/17 19:41
PHST- 2024/01/22 06:42 [medline]
PHST- 2023/11/18 11:41 [pubmed]
PHST- 2023/11/17 19:41 [entrez]
AID - 10.1055/a-2213-4375 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2024 Jan;132(1):33-38. doi: 10.1055/a-2213-4375. 
      Epub 2023 Nov 17.