PMID- 37978355
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20231127
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 23
IP  - 1
DP  - 2023 Nov 17
TI  - Predictive value of ellipsoid zone-related angle parameters in primary surgery of 
      large macular hole: a case control study.
PG  - 467
LID - 10.1186/s12886-023-03187-7 [doi]
LID - 467
AB  - BACKGROUND: To explore the predictive value of Ellipsoid Zone (EZ) -related angle 
      parameters for the outcome of primary macular hole surgery. METHODS: This was a 
      retrospective study. Patients diagnosed with large macular hole (MH) (minimum 
      diameter > 500 mum) between 2018 and 2021 were enrolled. All patients underwent 
      25-gauge pars plana vitrectomy, internal limiting membrane (ILM) peeling and air 
      tamponade. Spectral-domain OCT (SD-OCT) and best corrected visual acuity (BCVA) 
      were measured in preoperative and 2-week post-operative. Classic and angle 
      related parameters were measured via ImageJ. Angle regularity (AR) were defined 
      as the standard deviation of the angle parameters in vertical and horizontal 
      direction. RESULTS: Seventy-six eyes were included for analysis; 24 eyes showed 
      an unclosed macular hole at the 2-week postoperative and 52 eyes showed a closed 
      hole. Preoperatively, MLD (P < 0.001), BD (P = 0.009) and diameter of EZ/ELM 
      disruption (P = 0.002 and 0.025) in patients failed to close the hole after 
      primary surgery were significantly larger than those succeeded. EZ-MH 
      (P = 0.018), EZ-NFL (P = 0.006), EZ-GCL (P = 0.004), EZ-INL (P = 0.002), EZ-OPL 
      (P = 0.009) and EZ-ONL (P = 0.011) angles were smaller in patients with unclosed 
      hole. AR of the EZ-NFL (P = 0.009), EZ-GCL (P = 0.009), EZ-OPL (P = 0.023), 
      EZ-ONL (P = 0.048) and Basal-NFL (P = 0.030) angles among the unclosed patients 
      were significantly larger than those of the closed group. EZ-NFL (P = 0.015), 
      EZ-GCL (P = 0.004), EZ-INL (P < 0.001), EZ-OPL (P < 0.001), EZ-ONL (P < 0.001), 
      Basal (P = 0.023) and Basal-NFL (P < 0.001) angles of hole-unclosed patients 
      enlarged significantly after the surgery. CONCLUSIONS: Patients with large 
      macular holes and an increased EZ-related angle and angle AR are more likely to 
      experience unsuccessful outcomes following primary MH surgery. Therefore, 
      EZ-related angles hold potential as valuable parameters for predicting the 
      surgical outcome.
CI  - (c) 2023. The Author(s).
FAU - Xia, Huaqin
AU  - Xia H
AD  - Department of Ophthalmology, Peking University Third Hospital, Beijing, China.
FAU - Yang, Jiarui
AU  - Yang J
AD  - Department of Ophthalmology, Peking University Third Hospital, Beijing, China.
AD  - Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University 
      Third Hospital, Beijing, China.
FAU - Ding, Yi
AU  - Ding Y
AD  - Medical Oncology College, Beijing Shijitan Hospital, Capital Medical University, 
      Beijing, China.
FAU - Wang, Xinglin
AU  - Wang X
AD  - Department of Ophthalmology, Peking University Third Hospital, Beijing, China.
FAU - Liao, Yanfeng
AU  - Liao Y
AD  - Department of Ophthalmology, Peking University Third Hospital, Beijing, China.
FAU - Shi, Yiwen
AU  - Shi Y
AD  - Department of Ophthalmology, Peking University Third Hospital, Beijing, China.
FAU - Dou, Hongliang
AU  - Dou H
AD  - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. 
      douhongliang3736@sina.com.
AD  - Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University 
      Third Hospital, Beijing, China. douhongliang3736@sina.com.
FAU - Li, Xuemin
AU  - Li X
AD  - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. 
      lxmlxm66@sina.com.
AD  - Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University 
      Third Hospital, Beijing, China. lxmlxm66@sina.com.
LA  - eng
GR  - BMU2023YFJHPY031/Peking University Medicine Sailing Program for Young Scholars' 
      Scientific & Technological Innovation/
GR  - 7202229/Beijing Municipal Natural Science Foundation/
PT  - Journal Article
DEP - 20231117
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
SB  - IM
MH  - Humans
MH  - *Retinal Perforations/diagnosis/surgery
MH  - Case-Control Studies
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Visual Acuity
MH  - Vitrectomy
MH  - Basement Membrane/surgery
PMC - PMC10655441
OTO - NOTNLM
OT  - Ellipsoid zone
OT  - Macular hole
OT  - Vitrectomy
COIS- The authors declare no competing interests.
EDAT- 2023/11/18 11:43
MHDA- 2023/11/27 12:43
PMCR- 2023/11/17
CRDT- 2023/11/18 01:35
PHST- 2022/12/13 00:00 [received]
PHST- 2023/10/26 00:00 [accepted]
PHST- 2023/11/27 12:43 [medline]
PHST- 2023/11/18 11:43 [pubmed]
PHST- 2023/11/18 01:35 [entrez]
PHST- 2023/11/17 00:00 [pmc-release]
AID - 10.1186/s12886-023-03187-7 [pii]
AID - 3187 [pii]
AID - 10.1186/s12886-023-03187-7 [doi]
PST - epublish
SO  - BMC Ophthalmol. 2023 Nov 17;23(1):467. doi: 10.1186/s12886-023-03187-7.