PMID- 37979543
OWN - NLM
STAT- MEDLINE
DCOM- 20240115
LR  - 20240115
IS  - 2212-1102 (Electronic)
IS  - 2212-1099 (Linking)
VI  - 39
DP  - 2024 Jan
TI  - Choosing the Best Instrument for Measuring Health Spillover Effect in Caregivers 
      of Patients With Multiple Sclerosis.
PG  - 49-56
LID - S2212-1099(23)00085-7 [pii]
LID - 10.1016/j.vhri.2023.08.008 [doi]
AB  - OBJECTIVES: To measure the health spillover effect in caregivers of patients with 
      multiple sclerosis (MS), we aimed to select the best instrument from 2 common 
      health-related quality of life (QoL) instruments, the 3-level EQ-5D (EQ-5D-3L) 
      and the Health Utilities Index Mark 3 (HUI-3), by assessing them. METHODS: Using 
      consecutive sampling, 452 primary caregivers of patients with MS were asked to 
      fill out a Care-related QoL instrument (CarerQol-7D), EQ-5D-3L, HUI-3, and the 
      Center for Epidemiologic Studies Depression Scale between October 2019 and May 
      2020. Convergent and clinical validity were assessed to measure spillover effect 
      in caregivers of patients with MS. RESULTS: A strong correlation of 
      health-utility scores between EQ-5D-3L and HUI-3 (r = 0.914, P < .01) was 
      observed. The 95% limit of agreement (LoA) for CarerQol-7D and HUI-3 (-10.6 to 
      8.2) was narrower than the LoA for CarerQol-7D and EQ-5D-3L (-15.1 to 17.1). Both 
      EQ-5D-3L and HUI-3 proved clinical validity for the QoL of caregivers. The 
      CarerQoL-7D score was significantly lower in female (P < .001), single (P < 
      .014), lower-educated (P < .001), parent's relatives (P < .001), and unemployed 
      (P < .001) caregivers. CONCLUSIONS: We found that both, EQ-5D-3L and HUI-3, were 
      appropriate for measuring caregivers' QoL, although HUI-3 was a better choice 
      because of its narrower LoA. Our findings suggest researchers should use HUI-3 to 
      measure the quality-adjusted life-year of caregivers to aggregate with the QoL of 
      patients in the denominator of an economic evaluation equation, such as the 
      cost-effective ratio.
CI  - Copyright (c) 2023 International Society for Health Economics and Outcomes 
      Research. Published by Elsevier Inc. All rights reserved.
FAU - Faraji, Hoda
AU  - Faraji H
AD  - Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of 
      Pharmacy, Tehran University of Medical Sciences, Iran, Tehran.
FAU - Soleymani, Fatemeh
AU  - Soleymani F
AD  - Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of 
      Pharmacy, Tehran University of Medical Sciences, Iran, Tehran.
FAU - Yaseri, Mehdi
AU  - Yaseri M
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tehran 
      University of Medical Sciences, Iran, Tehran.
FAU - Sahraian, Mohammad Ali
AU  - Sahraian MA
AD  - Neurology Department, MS Research Centre, Neuroscience institute, Tehran 
      University of Medical Sciences, Iran, Tehran.
FAU - Abdollahiasl, Akbar
AU  - Abdollahiasl A
AD  - Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of 
      Pharmacy, Tehran University of Medical Sciences, Iran, Tehran.
FAU - Meftah, Azin
AU  - Meftah A
AD  - Faculty of Health Sciences Pharmacy, University of Eastern Finland, Finland, 
      Kuopio.
FAU - Nikfar, Shekoufeh
AU  - Nikfar S
AD  - Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of 
      Pharmacy, Tehran University of Medical Sciences, Iran, Tehran. Electronic 
      address: nikfar_sh@tums.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20231117
PL  - United States
TA  - Value Health Reg Issues
JT  - Value in health regional issues
JID - 101592642
SB  - IM
MH  - Humans
MH  - Female
MH  - *Quality of Life
MH  - Caregivers
MH  - *Multiple Sclerosis/therapy
MH  - Surveys and Questionnaires
MH  - Reproducibility of Results
OTO - NOTNLM
OT  - caregivers
OT  - cost-benefit analysis
OT  - multiple sclerosis
OT  - patient care
OT  - quality of life
EDAT- 2023/11/19 09:42
MHDA- 2024/01/15 12:43
CRDT- 2023/11/18 18:14
PHST- 2022/09/09 00:00 [received]
PHST- 2023/05/22 00:00 [revised]
PHST- 2023/08/01 00:00 [accepted]
PHST- 2024/01/15 12:43 [medline]
PHST- 2023/11/19 09:42 [pubmed]
PHST- 2023/11/18 18:14 [entrez]
AID - S2212-1099(23)00085-7 [pii]
AID - 10.1016/j.vhri.2023.08.008 [doi]
PST - ppublish
SO  - Value Health Reg Issues. 2024 Jan;39:49-56. doi: 10.1016/j.vhri.2023.08.008. Epub 
      2023 Nov 17.