PMID- 37979726
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20231216
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 206
DP  - 2023 Dec
TI  - Early rhythm control on diabetes-related complications and mortality in patients 
      with type 2 diabetes mellitus and atrial fibrillation.
PG  - 111020
LID - S0168-8227(23)00783-0 [pii]
LID - 10.1016/j.diabres.2023.111020 [doi]
AB  - AIMS: We evaluated the impact of early rhythm control (ERC) on diabetes-related 
      complications and mortality in subjects with type 2 diabetes mellitus (T2DM) and 
      atrial fibrillation (AF). METHODS: This observational cohort study based on the 
      Korean National Health Insurance Service claims database from 2009 to 2016, 
      divided newly diagnosed AF patients with T2DM into ERC or usual care groups based 
      on receiving rhythm control treatment within 1 year of AF diagnosis. The primary 
      outcome was ischemic stroke, and the secondary outcomes were macro/microvascular 
      complications, and all-cause death. RESULTS: Among 47,509 subjects (mean age 
      66.7 +/- 10.5 years; 61.8 % men; mean CHA(2)DS(2)-VASc score 4.6 +/- 1.8; mean 
      follow-up 4.3 +/- 2.3 years; mean DM duration 5.6 +/- 4.7 years), 23.1 % received 
      ERC, and 76.9 % did not (usual care group). ERC was associated with lower risks 
      of ischemic stroke, macrovascular and microvascular complications, and all-cause 
      death compared to usual care (adjusted hazard ratios [95 % confidence interval]: 
      0.77 [0.70-0.85], 0.79 [0.73-0.86], 0.86 [0.82-0.90], and 0.92 [0.87-0.98], 
      p < 0.001, <0.001, <0.001, and 0.012, respectively). CONCLUSIONS: Early rhythm 
      control was associated with reduced risks of diabetes-related complications and 
      mortality in subjects with T2DM and AF. Rhythm control within 1 year of AF 
      diagnosis with proper anticoagulation should be considered to prevent adverse 
      outcomes.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Lee, So-Ryoung
AU  - Lee SR
AD  - Division of Cardiology, Department of Internal Medicine, Seoul National 
      University Hospital, Seoul, Republic of Korea; Department of Internal Medicine, 
      Seoul National University College of Medicine, Seoul, Republic of Korea.
FAU - Choi, JungMin
AU  - Choi J
AD  - Division of Cardiology, Department of Internal Medicine, Seoul National 
      University Hospital, Seoul, Republic of Korea.
FAU - Choi, Eue-Keun
AU  - Choi EK
AD  - Division of Cardiology, Department of Internal Medicine, Seoul National 
      University Hospital, Seoul, Republic of Korea; Department of Internal Medicine, 
      Seoul National University College of Medicine, Seoul, Republic of Korea. 
      Electronic address: choiek17@snu.ac.kr.
FAU - Lee, HuiJin
AU  - Lee H
AD  - Division of Cardiology, Department of Internal Medicine, Seoul National 
      University Hospital, Seoul, Republic of Korea.
FAU - Han, MinJu
AU  - Han M
AD  - Division of Cardiology, Department of Internal Medicine, Seoul National 
      University Hospital, Seoul, Republic of Korea.
FAU - Ahn, Hyo-Jeong
AU  - Ahn HJ
AD  - Division of Cardiology, Department of Internal Medicine, Seoul National 
      University Hospital, Seoul, Republic of Korea.
FAU - Kwon, Soonil
AU  - Kwon S
AD  - Division of Cardiology, Department of Internal Medicine, Seoul National 
      University Hospital, Seoul, Republic of Korea.
FAU - Lee, Seung-Woo
AU  - Lee SW
AD  - Department of Medical Statistics, College of Medicine, Catholic University of 
      Korea, Seoul, Republic of Korea.
FAU - Han, Kyung-Do
AU  - Han KD
AD  - Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea.
FAU - Oh, Seil
AU  - Oh S
AD  - Division of Cardiology, Department of Internal Medicine, Seoul National 
      University Hospital, Seoul, Republic of Korea; Department of Internal Medicine, 
      Seoul National University College of Medicine, Seoul, Republic of Korea.
FAU - Y H Lip, Gregory
AU  - Y H Lip G
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Republic of Korea; Liverpool Center for Cardiovascular Science at the 
      University of Liverpool, Liverpool John Moores University and Liverpool Chest & 
      Heart Hospital, Liverpool, United Kingdom; Danish Center for Clinical Health 
      Services Research, Department of Clinical Medicine, Aalborg University, Aalborg, 
      Denmark.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20231117
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
SB  - IM
MH  - Male
MH  - Humans
MH  - Middle Aged
MH  - Aged
MH  - Female
MH  - *Atrial Fibrillation/complications/drug therapy
MH  - *Stroke/etiology/prevention & control/diagnosis
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Risk Assessment
MH  - *Hypertension/complications
MH  - *Diabetes Complications/complications
MH  - *Ischemic Stroke/complications
MH  - Risk Factors
OTO - NOTNLM
OT  - Atrial fibrillation
OT  - Death
OT  - Ischemic stroke
OT  - Microvascular/macrovascular complications
OT  - Type 2 diabetes mellitus
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/11/19 09:42
MHDA- 2023/12/17 09:44
CRDT- 2023/11/18 19:29
PHST- 2023/08/04 00:00 [received]
PHST- 2023/11/08 00:00 [revised]
PHST- 2023/11/15 00:00 [accepted]
PHST- 2023/12/17 09:44 [medline]
PHST- 2023/11/19 09:42 [pubmed]
PHST- 2023/11/18 19:29 [entrez]
AID - S0168-8227(23)00783-0 [pii]
AID - 10.1016/j.diabres.2023.111020 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2023 Dec;206:111020. doi: 10.1016/j.diabres.2023.111020. 
      Epub 2023 Nov 17.