PMID- 37979766
OWN - NLM
STAT- MEDLINE
DCOM- 20240110
LR  - 20240116
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 255
DP  - 2024 Jan
TI  - ZnO-incorporated alginate assemblies: Tunable pH-responsiveness and improved drug 
      delivery for cancer therapy.
PG  - 128189
LID - S0141-8130(23)05088-2 [pii]
LID - 10.1016/j.ijbiomac.2023.128189 [doi]
AB  - Delivering drugs selectively to tumor tissues is a significant challenge in 
      cancer therapy, and pH-responsive polymeric assemblies have shown great potential 
      in achieving this goal. In this study, we developed a pH-responsive 
      alginate-based assemblies, called (amine-modified ZnO)-oxidized alginate-PEG 
      ((ZnO-N)-OAl-PEG), for selective drug delivery in cancer treatment. The 
      incorporation of ZnO-N nanoparticles into the alginate-based assemblies enables 
      pH-responsiveness and maintains stability under physiological conditions. At an 
      acidic pH, (ZnO-N)-OAl-PEG disassembles due to the conversion of ZnO to Zn(2+), 
      which triggers the unloading of doxorubicin (DOX) from the imine bond between DOX 
      and alginate. This unloading results in the death of cancer cells and inhibition 
      of tumor growth. The anticancer efficacy of (DOX/ZnO-N)-OAl-PEG was demonstrated 
      in vitro and in vivo, providing promising prospects for cancer treatment based on 
      ZnO-induced pH-responsiveness. These findings may also inspire the development of 
      advanced drug delivery systems (DDSs) for cancer therapy.
CI  - Copyright (c) 2023. Published by Elsevier B.V.
FAU - Feng, Yecheng
AU  - Feng Y
AD  - Green Catalysis Center, College of Chemistry, Zhengzhou University, Zhengzhou 
      450001, PR China.
FAU - Yang, Wenjing
AU  - Yang W
AD  - Department of Anesthesiology, The First Affiliated Hospital, Zhengzhou 
      University, Zhengzhou 450002, PR China.
FAU - Shi, Xiaojing
AU  - Shi X
AD  - Laboratory Animal Center, State Key Laboratory of Esophageal Cancer Prevention & 
      Treatment, Academy of medical sciences, Zhengzhou University, Zhengzhou 450052, 
      PR China. Electronic address: shixiaojing@zzu.edu.cn.
FAU - Zhao, Xubo
AU  - Zhao X
AD  - Green Catalysis Center, College of Chemistry, Zhengzhou University, Zhengzhou 
      450001, PR China. Electronic address: xbz2016@zzu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20231116
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - SOI2LOH54Z (Zinc Oxide)
RN  - 0 (Alginates)
RN  - 80168379AG (Doxorubicin)
RN  - 0 (Drug Carriers)
SB  - IM
MH  - Humans
MH  - *Zinc Oxide/chemistry
MH  - Alginates
MH  - Drug Delivery Systems/methods
MH  - Doxorubicin/pharmacology/therapeutic use/chemistry
MH  - *Nanoparticles/chemistry
MH  - *Neoplasms/drug therapy
MH  - Hydrogen-Ion Concentration
MH  - Drug Carriers/chemistry
MH  - Cell Line, Tumor
OTO - NOTNLM
OT  - Alginate
OT  - Cancer therapy
OT  - ZnO nanoparticles
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/11/19 09:42
MHDA- 2024/01/10 06:41
CRDT- 2023/11/18 19:30
PHST- 2023/04/05 00:00 [received]
PHST- 2023/11/07 00:00 [revised]
PHST- 2023/11/15 00:00 [accepted]
PHST- 2024/01/10 06:41 [medline]
PHST- 2023/11/19 09:42 [pubmed]
PHST- 2023/11/18 19:30 [entrez]
AID - S0141-8130(23)05088-2 [pii]
AID - 10.1016/j.ijbiomac.2023.128189 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2024 Jan;255:128189. doi: 10.1016/j.ijbiomac.2023.128189. 
      Epub 2023 Nov 16.