PMID- 37981035
OWN - NLM
STAT- MEDLINE
DCOM- 20240115
LR  - 20240227
IS  - 1879-2596 (Electronic)
IS  - 0167-4889 (Linking)
VI  - 1871
IP  - 2
DP  - 2024 Feb
TI  - SQSTM1/p62 inhibition impairs pro-survival signaling in hypoxic human dendritic 
      cells.
PG  - 119625
LID - S0167-4889(23)00198-2 [pii]
LID - 10.1016/j.bbamcr.2023.119625 [doi]
AB  - The sequestosome 1 (SQSTM1)/p62 is an adaptor protein which plays multiple roles 
      in several cell functions, including cell survival and autophagy. Dendritic cells 
      (DCs) are the most prominent antigen presenting cells and during their lifespan 
      they are exposed to different oxygen tensions, including hypoxia. By using a 
      siRNA approach we found out that p62 was implicated in the maintenance of Erk1/2 
      phosphorylation and preservation of hypoxic DC survival, as well as in the 
      reduction of AMPK activation. Thus, p62 expression in DCs in hypoxic 
      microenvironments, such as in the lymphoid organs, may extend their lifespan to 
      ensure their functions.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Coppola, Federica
AU  - Coppola F
AD  - Cellular and Molecular Physiology Unit, Department of Molecular and Developmental 
      Medicine, University of Siena, Siena, Italy. Electronic address: 
      federica.coppola@student.unisi.it.
FAU - Monaci, Sara
AU  - Monaci S
AD  - Cellular and Molecular Physiology Unit, Department of Molecular and Developmental 
      Medicine, University of Siena, Siena, Italy. Electronic address: 
      sara.monaci2@unisi.it.
FAU - Falsini, Alessandro
AU  - Falsini A
AD  - Cellular and Molecular Physiology Unit, Department of Molecular and Developmental 
      Medicine, University of Siena, Siena, Italy. Electronic address: 
      alessandro.falsini@student.unisi.it.
FAU - Aldinucci, Carlo
AU  - Aldinucci C
AD  - Cellular and Molecular Physiology Unit, Department of Molecular and Developmental 
      Medicine, University of Siena, Siena, Italy. Electronic address: 
      carlo.aldinucci@unisi.it.
FAU - Filippi, Irene
AU  - Filippi I
AD  - Cellular and Molecular Physiology Unit, Department of Molecular and Developmental 
      Medicine, University of Siena, Siena, Italy. Electronic address: 
      filippire@gmail.com.
FAU - Rossi, Daniela
AU  - Rossi D
AD  - Cellular and Molecular Physiology Unit, Department of Molecular and Developmental 
      Medicine, University of Siena, Siena, Italy. Electronic address: 
      daniela.rossi@unisi.it.
FAU - Carraro, Fabio
AU  - Carraro F
AD  - Department of Medical Biotechnologies, University of Siena, Siena, Italy. 
      Electronic address: fabio.carraro@unisi.it.
FAU - Naldini, Antonella
AU  - Naldini A
AD  - Cellular and Molecular Physiology Unit, Department of Molecular and Developmental 
      Medicine, University of Siena, Siena, Italy. Electronic address: 
      antonella.naldini@unisi.it.
LA  - eng
PT  - Letter
PT  - Research Support, Non-U.S. Gov't
DEP - 20231118
PL  - Netherlands
TA  - Biochim Biophys Acta Mol Cell Res
JT  - Biochimica et biophysica acta. Molecular cell research
JID - 101731731
RN  - 0 (Sequestosome-1 Protein)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (SQSTM1 protein, human)
SB  - IM
MH  - Humans
MH  - Sequestosome-1 Protein/genetics/metabolism
MH  - *Signal Transduction/physiology
MH  - *Adaptor Proteins, Signal Transducing/genetics/metabolism
MH  - Hypoxia
MH  - Dendritic Cells/metabolism
OTO - NOTNLM
OT  - Cell survival
OT  - Dendritic cell
OT  - Hypoxia
OT  - SQSTM1/p62
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/11/20 00:43
MHDA- 2024/01/15 12:42
CRDT- 2023/11/19 19:28
PHST- 2023/07/31 00:00 [received]
PHST- 2023/10/09 00:00 [revised]
PHST- 2023/10/25 00:00 [accepted]
PHST- 2024/01/15 12:42 [medline]
PHST- 2023/11/20 00:43 [pubmed]
PHST- 2023/11/19 19:28 [entrez]
AID - S0167-4889(23)00198-2 [pii]
AID - 10.1016/j.bbamcr.2023.119625 [doi]
PST - ppublish
SO  - Biochim Biophys Acta Mol Cell Res. 2024 Feb;1871(2):119625. doi: 
      10.1016/j.bbamcr.2023.119625. Epub 2023 Nov 18.