PMID- 37985125
OWN - NLM
STAT- MEDLINE
DCOM- 20231125
LR  - 20231127
IS  - 2051-817X (Electronic)
IS  - 2051-817X (Linking)
VI  - 11
IP  - 22
DP  - 2023 Nov
TI  - The effects of short-term caloric restriction on cardiometabolic health in 
      overweight/obese men and women: A single-arm trial.
PG  - e15856
LID - 10.14814/phy2.15856 [doi]
LID - e15856
AB  - Overweight and obesity (Ow/Ob) is a risk factor for cardiometabolic disease. 
      Caloric restriction (CR) have been investigated but little is known about the 
      acute effects of CR and often such diets are not standardized. Thus, we aimed to 
      assess the impact of a new standardized 3-day CR diet (590 kcal/d intake) on 
      cardiometabolic health in weight-stable Ow/Ob individuals. In a single-arm 
      design, 15 Ow/Ob men and women were assessed pre-post a 3-day standardized CR 
      diet; specifically, body weight/composition (%body fat, visceral fat score (Vfs), 
      blood pressure (BP), and vascular stiffness (VS), resting energy expenditure 
      (REE), substrate utilization (respiratory quotient, RQ), and blood glucose/lipid 
      profile). CR lowered body weight (93.1 +/- 15.2 to 90.67 +/- 14.4 kg, p < 0.001, 
      d = 1.9), %fat (37.2 +/- 7.5 to 35.8 +/- 7.5%, p = 0.002, d = 1.1), and Vfs 
      (13.1 +/- 4.5 to 12.2 +/- 3.9 a.u., p = 0.002, d = 1.1), but not body water 
      (46.3 +/- 3.6 to 46.0 +/- 3.6%, p = 0.29). CR lowered VS (29.8 +/- 17.5 to 
      21.5 +/- 14.5%, p = 0.05, d = 0.6), but not BP (p > 0.05). Blood glucose (86 +/- 7 to 
      84 +/- 11 mg/dL, p = 0.33) and lipids (total cholesterol (196 +/- 49 to 
      203 +/- 54 mg/dL, p = 0.16) and TC/HDL (4.9 +/- 2.4 to 6.1 +/- 4.7, p = 0.13)) were 
      unchanged. RQ decreased with CR (0.84 +/- 0.01 to 0.76 +/- 0.00, p < 0.001, d = 1.9), 
      though REE was unchanged (p = 0.83). The 3-day CR diet significantly improved fat 
      metabolism, body weight and composition, and vascular stiffness.
CI  - (c) 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on 
      behalf of The Physiological Society and the American Physiological Society.
FAU - DeBlauw, Justin A
AU  - DeBlauw JA
AD  - Health and Human Physiological Sciences, Skidmore College, Saratoga Springs, New 
      York, USA.
FAU - Churchill, Anna I
AU  - Churchill AI
AD  - Health and Human Physiological Sciences, Skidmore College, Saratoga Springs, New 
      York, USA.
FAU - Yunda, Brigitte C
AU  - Yunda BC
AD  - Health and Human Physiological Sciences, Skidmore College, Saratoga Springs, New 
      York, USA.
FAU - Kotarsky, Christopher J
AU  - Kotarsky CJ
AD  - Health and Human Physiological Sciences, Skidmore College, Saratoga Springs, New 
      York, USA.
FAU - Caldwell, Abigail
AU  - Caldwell A
AD  - Health and Human Physiological Sciences, Skidmore College, Saratoga Springs, New 
      York, USA.
FAU - Ives, Stephen J
AU  - Ives SJ
AUID- ORCID: 0000-0002-7722-8818
AD  - Health and Human Physiological Sciences, Skidmore College, Saratoga Springs, New 
      York, USA.
LA  - eng
GR  - 2204-1028/Plexus Worldwide LLC/
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Physiol Rep
JT  - Physiological reports
JID - 101607800
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Female
MH  - Humans
MH  - Male
MH  - Blood Glucose/metabolism
MH  - Caloric Restriction
MH  - *Cardiovascular Diseases/etiology/prevention & control
MH  - Obesity/metabolism
MH  - *Overweight/metabolism
MH  - Weight Loss
PMC - PMC10659943
OTO - NOTNLM
OT  - adipokines
OT  - adiposity
OT  - fasting
OT  - fat oxidation
OT  - hormones
OT  - metabolism
OT  - weight loss
EDAT- 2023/11/21 01:07
MHDA- 2023/11/22 06:43
PMCR- 2023/11/20
CRDT- 2023/11/20 21:02
PHST- 2023/10/01 00:00 [revised]
PHST- 2023/06/07 00:00 [received]
PHST- 2023/10/24 00:00 [accepted]
PHST- 2023/11/22 06:43 [medline]
PHST- 2023/11/21 01:07 [pubmed]
PHST- 2023/11/20 21:02 [entrez]
PHST- 2023/11/20 00:00 [pmc-release]
AID - PHY215856 [pii]
AID - 10.14814/phy2.15856 [doi]
PST - ppublish
SO  - Physiol Rep. 2023 Nov;11(22):e15856. doi: 10.14814/phy2.15856.