PMID- 37986347
OWN - NLM
STAT- MEDLINE
DCOM- 20231122
LR  - 20231129
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 102
IP  - 46
DP  - 2023 Nov 17
TI  - Upregulated TC1 and downregulated Chibby were correlated with the aberrant 
      beta-catenin expression in laryngeal squamous cell carcinoma.
PG  - e36066
LID - 10.1097/MD.0000000000036066 [doi]
LID - e36066
AB  - As an important member of Wnt/beta-catenin signaling pathway, the aberrant 
      expression of beta-catenin has been implicated in many cancers. Chibby, a beta-catenin 
      binding partner, is an antagonist involved in this pathway. In contrast, thyroid 
      cancer 1 (TC1) as an activator of this pathway can relieve the antagonistic 
      activity of Chibby on the beta-catenin-mediated transcription and is high expressed 
      in human tumors. The objectives of this study were to examine the expression of 
      TC1, Chibby, and beta-catenin and investigate the association among them in 
      laryngeal squamous cell carcinoma (LSCC). The expression of TC1, Chibby, 
      beta-catenin, c-Myc, Cyclin D1, and matrix metalloproteinase-7 (MMP-7) were examined 
      by immunohistochemistry in samples from 53 LSCC patients. Compared with normal 
      laryngeal squamous epithelium (NLSE), there were upregulated expression of TC1, 
      downregulated expression of Chibby, and aberrant cytoplasmic expression of 
      beta-catenin in the LSCC tissues (P < .001). The high expression of TC1 was 
      correlated with the tumor site, advanced TNM and T stage, lymphovascular 
      invasion, and poor differentiation in LSCC tissues (P < .050). There were 
      correlations between the aberrant expression of beta-catenin and the tumor site, 
      advanced TNM and T stage, lymphovascular invasion, perineurial invasion, and poor 
      differentiation in LSCC tissues (P < .050). Upregulated TC1 and downregulated 
      Chibby were correlated with aberrant expression of beta-catenin (P < .001), but no 
      correlation between them (P = .076). The percent of abnormal expression of 
      beta-catenin in LSCC was 96.00% in TC1+/Chibby-, 73.68% in TC1+/Chibby+, 0.00% in 
      TC1-/Chibby-, and 0.00% in TC1-/Chibby + group (P < .001). High expression of 
      c-Myc, Cyclin D1, and MMP-7 was observed in LSCC tissues (P < .001). There was 
      statistically significant about the expression of Cyclin D1 and MMP-7 among the 
      groups of TC1+/Chibby-, TC1+/Chibby+, TC1-/Chibby-, and TC1-/Chibby + (P < .001), 
      but was not significance about the expression of c-Myc among them (P = .339). No 
      association was found between overall survival and the expression of TC1, Chibby, 
      and beta-catenin (P > .05). The upregulated expression of TC1 and downregulated 
      expression of Chibby were correlated with the aberrant expression of beta-catenin 
      and the high expression of Cyclin D1 and MMP-7 in LSCC tissues.
CI  - Copyright (c) 2023 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Ren, Gang
AU  - Ren G
AD  - Department of Otolaryngology, the First People's Hospital of Huzhou, the First 
      affiliated Hospital of Huzhou university, Huzhou, Zhejiang, China.
FAU - Ma, Bingliang
AU  - Ma B
AD  - Department of Otolaryngology, the First People's Hospital of Huzhou, the First 
      affiliated Hospital of Huzhou university, Huzhou, Zhejiang, China.
FAU - Wang, Jianqiu
AU  - Wang J
AD  - Department of Otolaryngology, the First People's Hospital of Huzhou, the First 
      affiliated Hospital of Huzhou university, Huzhou, Zhejiang, China.
FAU - Xu, Jue
AU  - Xu J
AD  - Department of Otolaryngology, the First People's Hospital of Huzhou, the First 
      affiliated Hospital of Huzhou university, Huzhou, Zhejiang, China.
FAU - Zhang, Xilin
AU  - Zhang X
AD  - Department of Central Laboratory, the First People's Hospital of Huzhou, the 
      First affiliated Hospital of Huzhou university, Huzhou, Zhejiang, China.
FAU - Yin, Chengyi
AU  - Yin C
AUID- ORCID: 0000-0001-8243-9524
AD  - Department of Otolaryngology, the First People's Hospital of Huzhou, the First 
      affiliated Hospital of Huzhou university, Huzhou, Zhejiang, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 136601-57-5 (Cyclin D1)
RN  - EC 3.4.24.23 (Matrix Metalloproteinase 7)
RN  - 0 (beta Catenin)
RN  - 0 (Carrier Proteins)
RN  - 0 (Nuclear Proteins)
SB  - IM
MH  - Humans
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Cyclin D1/metabolism
MH  - Matrix Metalloproteinase 7
MH  - beta Catenin/genetics
MH  - Carrier Proteins/genetics
MH  - Nuclear Proteins/genetics
MH  - *Head and Neck Neoplasms
MH  - *Laryngeal Neoplasms/pathology
MH  - Gene Expression Regulation, Neoplastic
PMC - PMC10659652
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2023/11/21 06:41
MHDA- 2023/11/22 06:43
PMCR- 2023/11/17
CRDT- 2023/11/21 04:50
PHST- 2023/11/22 06:43 [medline]
PHST- 2023/11/21 06:41 [pubmed]
PHST- 2023/11/21 04:50 [entrez]
PHST- 2023/11/17 00:00 [pmc-release]
AID - 00005792-202311170-00071 [pii]
AID - 10.1097/MD.0000000000036066 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2023 Nov 17;102(46):e36066. doi: 
      10.1097/MD.0000000000036066.