PMID- 37986705
OWN - NLM
STAT- Publisher
LR  - 20240521
IS  - 1942-7611 (Electronic)
IS  - 1942-7603 (Print)
IS  - 1942-7603 (Linking)
DP  - 2023 Nov 20
TI  - A multivariable analysis delineating hair color, hair dyeing, and hat wearing as 
      predictors of level of cocaine and MDMA detection in human hair samples.
LID - 10.1002/dta.3607 [doi]
AB  - Research suggests that hair color, hair dyeing, and perspiration can bias hair 
      test results regarding drug exposure, but research is needed to examine such 
      associations in a multivariable manner. In this epidemiology study, adults were 
      surveyed entering nightclubs and dance festivals in New York City, and 328 
      provided hair samples, which were analyzed using ultra-high-performance liquid 
      chromatography-tandem mass spectrometry to determine the level of detection of 
      cocaine and 3,4-methylenedioxymethamphetamine (MDMA). Reporting use was not an 
      inclusion criterion for analysis. We used two-part multivariable models to 
      delineate associations of hair color, past-year hair dyeing, and frequency of 
      past-month hat wearing (which may increase perspiration) in relation to any vs. 
      no detection of cocaine and MDMA as well as level of detection, controlling for 
      hair length, self-reported past-year cocaine/ecstasy/MDMA use, and age, sex, and 
      race/ethnicity. Those reporting having dyed their hair were at increased odds of 
      having any level of cocaine detected (adjusted odds ratio [aOR] = 3.75, 95% CI 
      confidence interval [CI]: 1.85-6.70), and compared to those with brown hair, 
      those with blond(e) hair on average had lower levels of cocaine (ng/mg) detected 
      (beta = -7.97, p = 0.025). Those reporting having dyed their hair were at 
      increased odds of having any level of MDMA detected (aOR = 3.05, 95% CI: 
      1.44-6.48), and compared to those who reported never wearing a hat, those who 
      reported wearing a hat daily or almost daily on average had lower levels of MDMA 
      (ng/mg) detected (beta = -6.61, p = 0.025). This study demonstrates the 
      importance of using multivariable models to delineate predictors of drug 
      detection.
CI  - (c) 2023 John Wiley & Sons, Ltd.
FAU - Palamar, Joseph J
AU  - Palamar JJ
AUID- ORCID: 0000-0002-8565-9415
AD  - Department of Population Health, NYU Grossman School of Medicine, New York, NY, 
      USA.
AD  - Center for Drug Use and HIV/HCV Research, School of Global Public Health, New 
      York University, New York, NY, USA.
FAU - Cleland, Charles M
AU  - Cleland CM
AD  - Department of Population Health, NYU Grossman School of Medicine, New York, NY, 
      USA.
AD  - Center for Drug Use and HIV/HCV Research, School of Global Public Health, New 
      York University, New York, NY, USA.
FAU - Vincenti, Marco
AU  - Vincenti M
AUID- ORCID: 0000-0002-6275-7194
AD  - Department of Chemistry, University of Turin, Turin, Italy.
AD  - Centro Regionale Antidoping, Orbassano, Italy.
FAU - Salomone, Alberto
AU  - Salomone A
AD  - Department of Chemistry, University of Turin, Turin, Italy.
AD  - Centro Regionale Antidoping, Orbassano, Italy.
LA  - eng
GR  - R01DA057289/DA/NIDA NIH HHS/United States
GR  - P30 DA011041/DA/NIDA NIH HHS/United States
GR  - R01 DA057289/DA/NIDA NIH HHS/United States
GR  - R01 DA044207/DA/NIDA NIH HHS/United States
GR  - R01DA044207/DA/NIDA NIH HHS/United States
GR  - P30DA01104/DA/NIDA NIH HHS/United States
PT  - Journal Article
DEP - 20231120
PL  - England
TA  - Drug Test Anal
JT  - Drug testing and analysis
JID - 101483449
SB  - IM
PMC - PMC11102931
MID - NIHMS1946722
OTO - NOTNLM
OT  - MDMA
OT  - cocaine
OT  - hair color
OT  - hair testing
COIS- CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest.
EDAT- 2023/11/21 06:42
MHDA- 2023/11/21 06:42
PMCR- 2025/05/20
CRDT- 2023/11/21 05:02
PHST- 2023/08/28 00:00 [revised]
PHST- 2023/07/10 00:00 [received]
PHST- 2023/11/01 00:00 [accepted]
PHST- 2025/05/20 00:00 [pmc-release]
PHST- 2023/11/21 06:42 [medline]
PHST- 2023/11/21 06:42 [pubmed]
PHST- 2023/11/21 05:02 [entrez]
AID - 10.1002/dta.3607 [doi]
PST - aheadofprint
SO  - Drug Test Anal. 2023 Nov 20:10.1002/dta.3607. doi: 10.1002/dta.3607.