PMID- 37987224
OWN - NLM
STAT- Publisher
LR  - 20231121
IS  - 1943-3670 (Electronic)
IS  - 0022-3492 (Linking)
DP  - 2023 Nov 21
TI  - Association of environmental polycyclic aromatic hydrocarbons exposure with 
      periodontitis in NHANES 2009-2014: A mixtures approach.
LID - 10.1002/JPER.23-0428 [doi]
AB  - BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) can invade and cause harm to 
      the human body through various pathways, but there is currently little research 
      on the relationship between mixed-PAHs exposure and periodontitis. The purpose of 
      this study was to examine the effects of mixed-urinary PAHs exposure on 
      periodontitis in adults in the United States. METHODS: The cross-sectional study 
      included 2749 subjects selected from the National Health and Nutrition 
      Examination Survey (NHANES) 2009-2014 cycles. A professional examination of the 
      periodontal status was conducted to distinguish between periodontitis and 
      non-periodontitis based on the Centers for Disease Control and 
      Prevention/American Academy of Periodontology (CDC/AAP) case definition. 
      Laboratory testing of urine samples was performed to obtain the levels of urinary 
      PAHs. Pearson correlation coefficients were utilized to determine the degree of 
      correlation between urinary PAHs, while weighted binary logistic regression and 
      Bayesian kernel machine regression (BKMR) were employed to evaluate the 
      relationship between urinary PAHs and periodontitis. RESULTS: In a 
      single-exposure model, 3-hydroxyfluorene (OH-3F), 2-hydroxyfluorene (OH-2F), 
      1-hydroxyphenanthrene (OH-1Ph), and 2-hydroxyphenanthrene and 
      3-hydroxyphenanthrene (OH-2,3Ph) were positively associated with periodontitis 
      risk. In the mixed-exposure model, BKMR analysis demonstrated that mixed exposure 
      to urinary PAHs was positively associated with periodontitis, with OH-2F being 
      the most critical factor for the overall mixed effects (posterior inclusion 
      probability [PIP] = 0.98). Univariate exposure-response function and univariate 
      effects analysis revealed a positive correlation between urinary OH-2F levels and 
      periodontitis. CONCLUSIONS: The study reveals a significant positive correlation 
      between exposure to mixed PAHs and periodontitis, with a particular emphasis on 
      the pivotal role of OH-2F. Mitigating PAHs in the environment may serve as a 
      preventive measure against periodontitis and alleviate its global public health 
      burden.
CI  - (c) 2023 American Academy of Periodontology.
FAU - Sun, Jinqiu
AU  - Sun J
AUID- ORCID: 0009-0007-6068-5143
AD  - Department of Physiology and Pathophysiology, School of Basic Medicine, Qingdao 
      University, Qingdao, Shandong, China.
FAU - Guo, Feifei
AU  - Guo F
AD  - Department of Physiology and Pathophysiology, School of Basic Medicine, Qingdao 
      University, Qingdao, Shandong, China.
FAU - Wang, Lin
AU  - Wang L
AD  - The Affiliated Qingdao Central Hospital of Qingdao University, the Second 
      Affiliated Hospital of Medical College of Qingdao University, Qingdao, Shandong, 
      China.
FAU - Han, Fulei
AU  - Han F
AD  - Department of Epidemiology and Health Statistics, Public Health College, Qingdao 
      University, Qingdao, Shandong, China.
FAU - Yang, Jia
AU  - Yang J
AD  - Jiafan Dental Clinic, Qingdao, Shandong, China.
FAU - Gao, Shengli
AU  - Gao S
AD  - Biomedical Centre, Qingdao Medical College, Qingdao University, Qingdao, 
      Shandong, China.
LA  - eng
PT  - Journal Article
DEP - 20231121
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
SB  - IM
OTO - NOTNLM
OT  - environmental exposure
OT  - nutrition surveys
OT  - periodontitis
OT  - polycyclic aromatic hydrocarbons
EDAT- 2023/11/21 06:42
MHDA- 2023/11/21 06:42
CRDT- 2023/11/21 05:43
PHST- 2023/10/22 00:00 [revised]
PHST- 2023/07/18 00:00 [received]
PHST- 2023/10/27 00:00 [accepted]
PHST- 2023/11/21 06:42 [medline]
PHST- 2023/11/21 06:42 [pubmed]
PHST- 2023/11/21 05:43 [entrez]
AID - 10.1002/JPER.23-0428 [doi]
PST - aheadofprint
SO  - J Periodontol. 2023 Nov 21. doi: 10.1002/JPER.23-0428.