PMID- 37987265
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231123
IS  - 2079-9721 (Print)
IS  - 2079-9721 (Electronic)
IS  - 2079-9721 (Linking)
VI  - 11
IP  - 4
DP  - 2023 Oct 31
TI  - Correlation of HbA1c Level with Lipid Profile in Type 2 Diabetes Mellitus 
      Patients Visiting a Primary Healthcare Center in Jeddah City, Saudi Arabia: A 
      Retrospective Cross-Sectional Study.
LID - 10.3390/diseases11040154 [doi]
LID - 154
AB  - INTRODUCTION: Type 2 diabetes mellitus (T2DM) patients are at high risk of 
      dyslipidemia, which in turn is associated with macrovascular diseases, such as 
      heart diseases and stroke, and microvascular diseases, such as neuropathy and 
      nephropathy. There are contradictory findings in the literature regarding the 
      relationship between glycated hemoglobin (HbA1c) and the lipid profile among T2DM 
      patients. This study was performed to investigate the association between HbA1c 
      level and the lipid profile in elderly T2DM patients at a primary care hospital 
      in Jeddah City, Saudi Arabia. METHODS: This study is a retrospective 
      cross-sectional study conducted at the Prince Abdul Majeed Healthcare Center 
      (PAMHC) in Jeddah, Saudi Arabia. The sociodemographic and clinical data of the 
      T2DM patients who had visited the PAMHC from 1 January 2020 to 31 December 2021, 
      were collected from the data registry of the PAMHC and analyzed for publication. 
      RESULTS: The study included a total of 988 T2DM patients (53.3% male). Of the 
      participants, 42.9% were aged between 55 and 64 years. Dyslipidemia parameters 
      were presented as high LDL-c (in 60.3% cases), low HDL-c (in 39.8% cases), high 
      triglycerides (in 34.9% cases), and high total cholesterol (in 34.8% cases). The 
      correlation of HbA1c with total cholesterol (TC) and triglycerides (TGs) was 
      positively significant, thereby highlighting the important link between glycemic 
      control and dyslipidemia. A mean increase of 4.88 mg/dL and 3.33 mmHg in TG level 
      and diastolic blood pressure, respectively, was associated with the male gender, 
      in comparison to the female gender. However, the male gender was significantly 
      associated with the reduction in the mean cholesterol level, BMI, HbA1c, HDL-c, 
      and LDL-c by 11.49 mg/dL, 1.39 kg/m(2), 0.31%, 7.47 mg/dL, and 5.6 mg/dL, 
      respectively, in comparison to the female gender. CONCLUSIONS: The results of 
      this study show that HbA1c was significantly associated with cholesterol and 
      triglyceride levels in the T2DM patients included in the study. Our findings 
      highlight the important relationship between glycemic control and dyslipidemia.
FAU - Sharahili, Abdulaziz Yahya
AU  - Sharahili AY
AD  - Department of Medical Laboratory Sciences, College of Applied Medical Science, 
      Majmaah University, Al Majmaah 11952, Saudi Arabia.
FAU - Mir, Shabir Ahmad
AU  - Mir SA
AUID- ORCID: 0000-0001-8039-1598
AD  - Department of Medical Laboratory Sciences, College of Applied Medical Science, 
      Majmaah University, Al Majmaah 11952, Saudi Arabia.
AD  - Health and Basic Sciences Research Center, Majmaah University, Al Majmaah 11952, 
      Saudi Arabia.
FAU - ALDosari, Sahar
AU  - ALDosari S
AD  - Department of Medical Laboratory Sciences, College of Applied Medical Science, 
      Majmaah University, Al Majmaah 11952, Saudi Arabia.
FAU - Manzar, Md Dilshad
AU  - Manzar MD
AUID- ORCID: 0000-0002-5571-3310
AD  - Department of Nursing, College of Applied Medical Science, Majmaah University, Al 
      Majmaah 11952, Saudi Arabia.
FAU - Alshehri, Bader
AU  - Alshehri B
AUID- ORCID: 0000-0002-2847-0106
AD  - Department of Medical Laboratory Sciences, College of Applied Medical Science, 
      Majmaah University, Al Majmaah 11952, Saudi Arabia.
AD  - Health and Basic Sciences Research Center, Majmaah University, Al Majmaah 11952, 
      Saudi Arabia.
FAU - Al Othaim, Ayoub
AU  - Al Othaim A
AD  - Department of Medical Laboratory Sciences, College of Applied Medical Science, 
      Majmaah University, Al Majmaah 11952, Saudi Arabia.
FAU - Alghofaili, Fayez
AU  - Alghofaili F
AUID- ORCID: 0000-0002-1505-3581
AD  - Department of Medical Laboratory Sciences, College of Applied Medical Science, 
      Majmaah University, Al Majmaah 11952, Saudi Arabia.
FAU - Madkhali, Yahya
AU  - Madkhali Y
AD  - Department of Medical Laboratory Sciences, College of Applied Medical Science, 
      Majmaah University, Al Majmaah 11952, Saudi Arabia.
FAU - Albenasy, Kamal Shaker
AU  - Albenasy KS
AD  - Department of Medical Laboratory Sciences, College of Applied Medical Science, 
      Majmaah University, Al Majmaah 11952, Saudi Arabia.
FAU - Alotaibi, Jazi S
AU  - Alotaibi JS
AUID- ORCID: 0000-0002-2355-3949
AD  - Department of Nursing, College of Applied Medical Science, Majmaah University, Al 
      Majmaah 11952, Saudi Arabia.
LA  - eng
GR  - R-2023-XXX/Majmaah University/
PT  - Journal Article
DEP - 20231031
PL  - Switzerland
TA  - Diseases
JT  - Diseases (Basel, Switzerland)
JID - 101636232
PMC - PMC10660465
OTO - NOTNLM
OT  - HbA1C
OT  - Saudi Arabia
OT  - diabetes mellitus
OT  - dyslipidemia
OT  - lipid profile
COIS- The authors have no conflict of interest.
EDAT- 2023/11/21 12:42
MHDA- 2023/11/21 12:43
PMCR- 2023/10/31
CRDT- 2023/11/21 06:26
PHST- 2023/09/13 00:00 [received]
PHST- 2023/10/23 00:00 [revised]
PHST- 2023/10/27 00:00 [accepted]
PHST- 2023/11/21 12:43 [medline]
PHST- 2023/11/21 12:42 [pubmed]
PHST- 2023/11/21 06:26 [entrez]
PHST- 2023/10/31 00:00 [pmc-release]
AID - diseases11040154 [pii]
AID - diseases-11-00154 [pii]
AID - 10.3390/diseases11040154 [doi]
PST - epublish
SO  - Diseases. 2023 Oct 31;11(4):154. doi: 10.3390/diseases11040154.