PMID- 37988712
OWN - NLM
STAT- MEDLINE
DCOM- 20231123
LR  - 20231123
IS  - 1473-2165 (Electronic)
IS  - 1473-2130 (Linking)
VI  - 22 Suppl 3
DP  - 2023 Nov
TI  - Literature review of adverse events associated with cryolipolysis.
PG  - 31-36
LID - 10.1111/jocd.16000 [doi]
AB  - BACKGROUND: Cryolipolysis is a noninvasive procedure for localized fat reduction 
      and body contouring. This technique utilizes controlled cooling to induce 
      adipocyte apoptosis without damage to overlying skin and other tissue. Although 
      the procedure was once thought to be relatively harmless, recent studies have 
      shed light on the risks of adverse effects (AEs). AIMS: The aim of this article 
      was to review AEs in cryolipolysis as published in clinical data. METHODS: A 
      comprehensive search was performed in PubMed, using relevant keywords such as 
      "cryolipolysis," "CoolSculpting," "adverse effects," "complications," and "side 
      effects" with no set data range. The search was limited to studies published in 
      English. The selected studies encompassed a variety of study designs, including 
      randomized controlled trials, prospective cohort studies, case series, case 
      reports, and reviews. CONCLUSIONS: Since its FDA approval in 2010, our 
      understanding of the potential risks and complications associated with 
      cryolipolysis has grown significantly, and shown that the procedure may not be as 
      harmless as once thought. Continued post-market surveillance of cryolipolysis 
      devices combined with documenting of AE cases help providers better understand 
      the true risks associated with this procedure. As "cryolipolysis" and 
      "CoolSculpting" are often used interchangeably, further research is needed to 
      understand if AEs such as paradoxical adipose hyperplasia (PAH) that occur both 
      inside and outside the United States are CoolSculpting cases or linked to other 
      devices. Additionally, further studies are needed to understand the 
      pathophysiology of such sequelae as PAH, and to better recognize the risks and 
      potential complications associated with cryolipolysis so that we can more 
      accurately inform patients.
CI  - (c) 2023 The Authors. Journal of Cosmetic Dermatology published by Wiley 
      Periodicals LLC.
FAU - Deligonul, Fatma Zeynep
AU  - Deligonul FZ
AD  - University of Incarnate Word School of Osteopathic Medicine, San Antonio, Texas, 
      USA.
FAU - Yousefian, Faraz
AU  - Yousefian F
AUID- ORCID: 0000-0001-7032-7795
AD  - University of Incarnate Word School of Osteopathic Medicine, San Antonio, Texas, 
      USA.
AD  - Goodman Dermatology, Roswell, Georgia, USA.
FAU - Gold, Michael H
AU  - Gold MH
AUID- ORCID: 0000-0002-5183-5433
AD  - Gold Skin Care Center, Nashville, Tennessee, USA.
AD  - Tennessee Clinical Research Center, Nashville, Tennessee, USA.
LA  - eng
GR  - Allergan Aesthetics/
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Cosmet Dermatol
JT  - Journal of cosmetic dermatology
JID - 101130964
SB  - IM
MH  - Humans
MH  - *Cryotherapy/adverse effects/methods
MH  - *Lipectomy/methods
MH  - Treatment Outcome
MH  - Subcutaneous Fat/surgery
MH  - Prospective Studies
MH  - Obesity/etiology
MH  - Hyperplasia/etiology
MH  - Randomized Controlled Trials as Topic
OTO - NOTNLM
OT  - adverse effects; cryotherapy
OT  - body contouring
OT  - cryolipolysis
OT  - nonsurgical fat reduction
OT  - paradoxical adipose hyperplasia
EDAT- 2023/11/21 18:43
MHDA- 2023/11/23 06:42
CRDT- 2023/11/21 16:43
PHST- 2023/07/31 00:00 [received]
PHST- 2023/09/06 00:00 [accepted]
PHST- 2023/11/23 06:42 [medline]
PHST- 2023/11/21 18:43 [pubmed]
PHST- 2023/11/21 16:43 [entrez]
AID - 10.1111/jocd.16000 [doi]
PST - ppublish
SO  - J Cosmet Dermatol. 2023 Nov;22 Suppl 3:31-36. doi: 10.1111/jocd.16000.