PMID- 37988867
OWN - NLM
STAT- MEDLINE
DCOM- 20231205
LR  - 20240206
IS  - 1873-3336 (Electronic)
IS  - 0304-3894 (Linking)
VI  - 464
DP  - 2024 Feb 15
TI  - Association between manganese exposure in heavy metals mixtures and the 
      prevalence of sarcopenia in US adults from NHANES 2011-2018.
PG  - 133005
LID - S0304-3894(23)02289-6 [pii]
LID - 10.1016/j.jhazmat.2023.133005 [doi]
AB  - Environmental pollution is identified as an essential risk factor for sarcopenia. 
      However, the effect of manganese (Mn) exposure on the prevalence of sarcopenia is 
      not assessed. Our study investigated the correlation between blood Mn 
      concentration and sarcopenia risk in the National Health and Nutrition 
      Examination Survey (NHANES) from 2011 to 2018. Three statistical methods were 
      used to assess these correlations. Mediation analysis was performed to explore 
      the role of inflammation in Mn exposure-induced sarcopenia. Of the 4957 
      individuals enrolled in this study, 398 (8 %) were diagnosed with sarcopenia. We 
      found a positive association between the log10 Mn concentration and the 
      prevalence of sarcopenia in the logistic regression model. Moreover, heavy metals 
      mixtures were positively correlated with the prevalence of sarcopenia, with Mn 
      identified as the main contributor to this association in the weighted quantile 
      sum (WQS) and Bayesian kernel machine regression (BKMR) models. Furthermore, 
      inflammation mediated the relationship between Mn exposure and the prevalence of 
      sarcopenia, explaining 7.29 % of the effect (odds ratio: 0.03, 0.19, P = 0.002). 
      Thus, our study results revealed that excessive Mn exposure is a contributing 
      factor for sarcopenia. More prospective studies are required to examine the 
      association between Mn exposure and the prevalence of sarcopenia.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Huang, Qiong
AU  - Huang Q
AD  - Department of Emergency Medicine, Second Xiangya Hospital, Central South 
      University, Changsha 410011, China; Department of Geriatric Respiratory and 
      Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 
      410008, China; Department of Geriatric Medicine, Xiangya Hospital, Central South 
      University, Changsha 410008, China.
FAU - Wan, Jinfa
AU  - Wan J
AD  - Department of Emergency Medicine, Second Xiangya Hospital, Central South 
      University, Changsha 410011, China; Emergency Medicine and Difficult Diseases 
      Institute, Central South University, Changsha 410011, China.
FAU - Nan, Wenbin
AU  - Nan W
AD  - Department of Emergency Medicine, Second Xiangya Hospital, Central South 
      University, Changsha 410011, China; Emergency Medicine and Difficult Diseases 
      Institute, Central South University, Changsha 410011, China.
FAU - Li, Siqi
AU  - Li S
AD  - Department of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, 
      Central South University, Changsha 410008, China; Department of Geriatric 
      Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
FAU - He, Baimei
AU  - He B
AD  - Department of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, 
      Central South University, Changsha 410008, China; Department of Geriatric 
      Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
FAU - Peng, Zhenyu
AU  - Peng Z
AD  - Department of Emergency Medicine, Second Xiangya Hospital, Central South 
      University, Changsha 410011, China; Emergency Medicine and Difficult Diseases 
      Institute, Central South University, Changsha 410011, China. Electronic address: 
      pengzhenyu1999@csu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231115
PL  - Netherlands
TA  - J Hazard Mater
JT  - Journal of hazardous materials
JID - 9422688
RN  - 42Z2K6ZL8P (Manganese)
RN  - 0 (Metals, Heavy)
SB  - IM
MH  - Humans
MH  - Adult
MH  - Manganese/toxicity/analysis
MH  - Nutrition Surveys
MH  - Prevalence
MH  - Bayes Theorem
MH  - *Sarcopenia/chemically induced/epidemiology
MH  - *Metals, Heavy/toxicity/analysis
MH  - Inflammation
MH  - Environmental Exposure/analysis
OTO - NOTNLM
OT  - Heavy metals
OT  - Inflammation
OT  - Manganese
OT  - NHANES
OT  - Sarcopenia
COIS- Declaration of Competing Interest The authors declare no conflict of interest.
EDAT- 2023/11/22 00:42
MHDA- 2023/12/05 12:43
CRDT- 2023/11/21 18:20
PHST- 2023/08/12 00:00 [received]
PHST- 2023/10/10 00:00 [revised]
PHST- 2023/11/12 00:00 [accepted]
PHST- 2023/12/05 12:43 [medline]
PHST- 2023/11/22 00:42 [pubmed]
PHST- 2023/11/21 18:20 [entrez]
AID - S0304-3894(23)02289-6 [pii]
AID - 10.1016/j.jhazmat.2023.133005 [doi]
PST - ppublish
SO  - J Hazard Mater. 2024 Feb 15;464:133005. doi: 10.1016/j.jhazmat.2023.133005. Epub 
      2023 Nov 15.