PMID- 37989112
OWN - NLM
STAT- MEDLINE
DCOM- 20240206
LR  - 20240206
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 185
IP  - 2
DP  - 2024
TI  - Clinical Features of Quail Egg Ingestion in Patients with Acquired Tolerance to 
      Hen Eggs: A Case Series Study.
PG  - 152-157
LID - 10.1159/000534825 [doi]
AB  - INTRODUCTION: Patients with hen's egg allergy are often instructed to avoid 
      consuming other avian eggs, such as quail eggs. However, it is unclear whether 
      patients with an acquired tolerance to hen eggs continue to avoid consuming quail 
      eggs. This study aimed to evaluate the clinical features of quail egg ingestion. 
      METHODS: This prospective case series included children aged >/=1 year with hen's 
      egg allergy who were recruited between October 2019 and February 2021 in our 
      hospital. We conducted an oral food challenge (OFC) with three boiled quail eggs 
      to evaluate the clinical features of quail egg ingestion in patients with 
      acquired tolerance to hen eggs. The primary outcome was a positive OFC after 
      ingesting three quail eggs. Secondary outcomes were cross-antigenicity between 
      hen and quail eggs observed through the skin prick test (SPT) and pattern of 
      quail egg allergy, comprising the onset of reaction, and severity. The 
      correlation between the diameters of the wheals with SPT in hen and quail eggs 
      was evaluated using the Pearson product-moment correlation coefficient. RESULTS: 
      A total of 62 patients underwent the quail egg OFC. The median (interquartile 
      range) age of the participants was 3 (2-5) years. Thirty-three (53%) patients had 
      a history of anaphylaxis due to hen eggs. The median total immunoglobulin E (IgE) 
      level in patients who underwent the OFC with half a heated whole hen's egg was 
      271 (98-593) IU/mL. The median specific IgE level in egg white and ovomucoid was 
      9.7 (3.2-21.5) and 4.4 (1.3-6.9) UA/mL, respectively. The quail egg OFC results 
      revealed that none of the 59 patients who ate the three quail eggs completely had 
      an allergic reaction. The SPT-positive and SPT-negative rates in raw and boiled 
      hen and quail egg whites were both correlated. The diameters of wheals with SPT 
      in raw hen and quail egg whites and yolks were positively correlated. CONCLUSION: 
      Patients with an acquired tolerance to hen eggs may not be required to avoid 
      consuming quail eggs.
CI  - (c) 2023 S. Karger AG, Basel.
FAU - Yamashita, Kosei
AU  - Yamashita K
AD  - Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.
FAU - Okada, Yuki
AU  - Okada Y
AD  - Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.
FAU - Honda, Aiko
AU  - Honda A
AD  - Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.
FAU - Kunigami, Chihiro
AU  - Kunigami C
AD  - Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.
FAU - Maeda, Mayu
AU  - Maeda M
AD  - Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.
FAU - Nakamura, Toshinori
AU  - Nakamura T
AD  - Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.
FAU - Kamiya, Taro
AU  - Kamiya T
AD  - Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.
FAU - Imai, Takanori
AU  - Imai T
AD  - Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20231121
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Allergens)
SB  - IM
MH  - Child
MH  - Humans
MH  - Female
MH  - Animals
MH  - *Egg Hypersensitivity
MH  - Chickens
MH  - Eggs
MH  - Skin Tests
MH  - Immunoglobulin E
MH  - Allergens
MH  - Eating
OTO - NOTNLM
OT  - Clinical feature
OT  - Food allergy
OT  - Hen's egg
OT  - Oral food challenge
OT  - Quail egg
EDAT- 2023/11/22 00:42
MHDA- 2024/02/06 06:42
CRDT- 2023/11/21 18:33
PHST- 2023/08/30 00:00 [received]
PHST- 2023/10/21 00:00 [accepted]
PHST- 2024/02/06 06:42 [medline]
PHST- 2023/11/22 00:42 [pubmed]
PHST- 2023/11/21 18:33 [entrez]
AID - 000534825 [pii]
AID - 10.1159/000534825 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2024;185(2):152-157. doi: 10.1159/000534825. Epub 2023 
      Nov 21.