PMID- 37991112
OWN - NLM
STAT- Publisher
LR  - 20231122
IS  - 1942-7611 (Electronic)
IS  - 1942-7603 (Linking)
DP  - 2023 Nov 22
TI  - Design of smart nanoparticles for the electrochemical detection of 
      3,4-methylenedioxymethamphetamine to allow in field screening by law enforcement 
      officers.
LID - 10.1002/dta.3605 [doi]
AB  - A portable and highly sensitive sensor was designed for the specific detection of 
      3,4-methyl-enedioxy-methamphetamine (MDMA), in a range of field-testing 
      situations. The sensor can detect MDMA in street samples, even when other 
      controlled substances drugs, or adulterants are present. In this work, we report 
      for the first time a sensor using electroactive molecularly imprinted polymer 
      nanoparticles computationally designed to recognize MDMA and then produced using 
      solid phase synthesis. A composite comprising chitosan, reduced graphene oxide, 
      and molecularly imprinted polymer nanoparticles synthesized for MDMA for the 
      first time was immobilized on screen-printed carbon electrodes. The sensors 
      displayed a satisfactory sensitivity (106.8 nA x muM(-1) ), limit of detection 
      (1.6 nM; 0.31 ng/mL), and recoveries (92-99%). The accuracy of the results was 
      confirmed through validation using Ultra-High Performance Liquid Chromatography 
      coupled with tandem Mass Spectrometry (UPLC-MS/MS). This technology could be used 
      in forensic analysis and make it possible to selectively detect MDMA in street 
      samples.
CI  - (c) 2023 John Wiley & Sons, Ltd.
FAU - Truta, Florina Maria
AU  - Truta FM
AD  - Department of Analytical Chemistry, "Iuliu Hatieganu" University of Medicine and 
      Pharmacy, Cluj-Napoca, Romania.
FAU - Cruz, Alvaro Garcia
AU  - Cruz AG
AD  - Chemistry Department, University of Leicester, Leicester, UK.
FAU - Dragan, Ana-Maria
AU  - Dragan AM
AUID- ORCID: 0000-0002-1488-5917
AD  - Department of Analytical Chemistry, "Iuliu Hatieganu" University of Medicine and 
      Pharmacy, Cluj-Napoca, Romania.
FAU - Tertis, Mihaela
AU  - Tertis M
AUID- ORCID: 0000-0003-2572-6724
AD  - Department of Analytical Chemistry, "Iuliu Hatieganu" University of Medicine and 
      Pharmacy, Cluj-Napoca, Romania.
FAU - Cowen, Todd
AU  - Cowen T
AD  - Chemistry Department, University of Leicester, Leicester, UK.
FAU - Stefan, Maria-Geogia
AU  - Stefan MG
AD  - Department of Toxicology, Faculty of Pharmacy, Iuliu Hatieganu University of 
      Medicine and Pharmacy, Cluj-Napoca, Romania.
FAU - Topala, Tamara
AU  - Topala T
AD  - Department of General and Inorganic Chemistry, "Iuliu Hatieganu" University of 
      Medicine and Pharmacy, Cluj-Napoca, Romania.
FAU - Slosse, Amorn
AU  - Slosse A
AD  - Drugs and Toxicology Department, National Institute for Criminalistics and 
      Criminology (NICC), Brussels, Belgium.
FAU - Piletska, Elena
AU  - Piletska E
AD  - Chemistry Department, University of Leicester, Leicester, UK.
FAU - Van Durme, Filip
AU  - Van Durme F
AD  - Drugs and Toxicology Department, National Institute for Criminalistics and 
      Criminology (NICC), Brussels, Belgium.
FAU - Kiss, Bela
AU  - Kiss B
AUID- ORCID: 0000-0003-3036-5345
AD  - Department of Toxicology, Faculty of Pharmacy, Iuliu Hatieganu University of 
      Medicine and Pharmacy, Cluj-Napoca, Romania.
FAU - De Wael, Karolien
AU  - De Wael K
AD  - A-Sense Lab, University of Antwerp, Antwerp, Belgium.
AD  - NANOlab Ctr Excellence, University of Antwerp, Antwerp, Belgium.
FAU - Piletsky, Sergey A
AU  - Piletsky SA
AD  - Chemistry Department, University of Leicester, Leicester, UK.
FAU - Cristea, Cecilia
AU  - Cristea C
AUID- ORCID: 0000-0002-4158-3324
AD  - Department of Analytical Chemistry, "Iuliu Hatieganu" University of Medicine and 
      Pharmacy, Cluj-Napoca, Romania.
LA  - eng
GR  - 833787/Horizon 2020 research and innovation programme under the European project 
      BorderSens/
GR  - PCD 774/5/11.01.2023/"Iuliu Hatieganu" University of Medicine and Pharmacy 
      Cluj-Napoca/
PT  - Journal Article
DEP - 20231122
PL  - England
TA  - Drug Test Anal
JT  - Drug testing and analysis
JID - 101483449
SB  - IM
OTO - NOTNLM
OT  - MDMA
OT  - electrochemical sensor
OT  - forensic applications
OT  - illicit drugs detection
OT  - nanoMIPs
EDAT- 2023/11/22 12:43
MHDA- 2023/11/22 12:43
CRDT- 2023/11/22 07:04
PHST- 2023/10/06 00:00 [revised]
PHST- 2023/05/14 00:00 [received]
PHST- 2023/10/30 00:00 [accepted]
PHST- 2023/11/22 12:43 [medline]
PHST- 2023/11/22 12:43 [pubmed]
PHST- 2023/11/22 07:04 [entrez]
AID - 10.1002/dta.3605 [doi]
PST - aheadofprint
SO  - Drug Test Anal. 2023 Nov 22. doi: 10.1002/dta.3605.