PMID- 37991127
OWN - NLM
STAT- MEDLINE
DCOM- 20240426
LR  - 20240426
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 102
IP  - 4
DP  - 2024 Jun
TI  - Central macular morphology and optic nerve fibre layer thickness in young adults 
      born premature and screened for retinopathy of prematurity.
PG  - 391-400
LID - 10.1111/aos.15814 [doi]
AB  - PURPOSE: To investigate central retinal morphology and optic retinal nerve fibre 
      layer (RNFL) in prematurely born young adults and compare to term born controls. 
      MATERIALS AND METHODS: The participants were 59 prematurely born individuals, 
      with a birthweight </=1.500 g, and 44 term born controls, all 25-29 years of age. 
      Visual acuity (VA) and contrast sensitivity (CS) were assessed. The retinal 
      macular thickness, ganglion cell-inner plexiform layer (GC-IPL) thickness and 
      RNFL thickness were assessed with Cirrus optical coherence tomography (OCT). 
      RESULTS: Central macular thickness was increased (mean 26.7 mum) in prematurely 
      born individuals compared to controls. The macular GC-IPL was thinner (mean 
      3.84 mum), also when excluding those with previous retinopathy of prematurity 
      (ROP) and those with neurological complications. Gestational age at birth and 
      previous treatment of ROP were risk factors for a thicker macula, however, not 
      for reduced GC-IPL. The average peripapillary RNFL was thinner (mean 4.61 mum) in 
      the prematurely born individuals, also when excluding those with previous ROP 
      and/or neurological complications. Within the prematurely born group, treated ROP 
      was correlated with increased average RNFL. Further, both better VA and CS were 
      associated with thinner optic nerve RNFL and thicker average GC-IPL. CONCLUSION: 
      Macular and optic nerve morphology were influenced by premature birth as assessed 
      with OCT in adult individuals. Gestational age at birth and treatment for ROP 
      seemed to affect central macular thickness, and treated ROP affected the 
      peripapillary RNFL. Thus, retinal sequelae remained in adulthood.
CI  - (c) 2023 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on 
      behalf of Acta Ophthalmologica Scandinavica Foundation.
FAU - Petursdottir, Dyrleif
AU  - Petursdottir D
AUID- ORCID: 0000-0002-9757-1373
AD  - Department of Surgical Sciences/Ophthalmology, Uppsala University, Uppsala, 
      Sweden.
AD  - Department of Ophthalmology, Faculty of Medicine, National University Hospital, 
      University of Iceland, Reykjavik, Iceland.
FAU - Akerblom, Hanna
AU  - Akerblom H
AD  - Department of Surgical Sciences/Ophthalmology, Uppsala University, Uppsala, 
      Sweden.
AD  - Centre for Clinical Research Vastmanland, Hospital of Vastmanland, Vasteras, 
      Sweden.
FAU - Holmstrom, Gerd
AU  - Holmstrom G
AUID- ORCID: 0000-0002-5600-7186
AD  - Department of Surgical Sciences/Ophthalmology, Uppsala University, Uppsala, 
      Sweden.
FAU - Larsson, Eva
AU  - Larsson E
AUID- ORCID: 0000-0001-9674-0094
AD  - Department of Surgical Sciences/Ophthalmology, Uppsala University, Uppsala, 
      Sweden.
LA  - eng
GR  - Ogonfonden/
GR  - Synskadades vanner i Uppsala lan/
GR  - The Carmen and Bertil Regner Foundation/
GR  - The Crown Princess Margaretha Foundation for the Visually Impaired/
PT  - Journal Article
DEP - 20231122
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
SB  - IM
MH  - Humans
MH  - *Retinopathy of Prematurity/diagnosis
MH  - *Tomography, Optical Coherence/methods
MH  - Female
MH  - Male
MH  - *Nerve Fibers/pathology
MH  - *Retinal Ganglion Cells/pathology
MH  - Adult
MH  - *Gestational Age
MH  - *Visual Acuity
MH  - *Macula Lutea/pathology/diagnostic imaging
MH  - Infant, Newborn
MH  - Infant, Premature
OTO - NOTNLM
OT  - ganglion cell-inner plexiform layer (GC-IPL)
OT  - macular thickness
OT  - optical coherence tomography (OCT)
OT  - prematurity
OT  - retinal nerve fibre layer (RNFL)
OT  - retinopathy of prematurity (ROP)
EDAT- 2023/11/22 12:43
MHDA- 2024/04/26 13:21
CRDT- 2023/11/22 07:05
PHST- 2023/10/08 00:00 [revised]
PHST- 2023/09/10 00:00 [received]
PHST- 2023/11/06 00:00 [accepted]
PHST- 2024/04/26 13:21 [medline]
PHST- 2023/11/22 12:43 [pubmed]
PHST- 2023/11/22 07:05 [entrez]
AID - 10.1111/aos.15814 [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2024 Jun;102(4):391-400. doi: 10.1111/aos.15814. Epub 2023 Nov 
      22.