PMID- 37991925
OWN - NLM
STAT- MEDLINE
DCOM- 20240329
LR  - 20240329
IS  - 1554-527X (Electronic)
IS  - 0736-0266 (Linking)
VI  - 42
IP  - 4
DP  - 2024 Apr
TI  - Effect of mesenchymal stromal cells transplantation on the outcomes of patients 
      with knee osteoarthritis: A systematic review and meta-analysis.
PG  - 753-768
LID - 10.1002/jor.25724 [doi]
AB  - Cell therapy has been explored as a new regenerative treatment for osteoarthritis 
      in the field of regenerative medicine. However, the efficacy of stem cell 
      transplantation from different sources for the treatment of knee osteoarthritis 
      (KOA) remains controversial. This study integrates and evaluates the previously 
      published data of stem cell transplantation for KOA to explore the curative 
      effect of different stem cells. We conducted a meta-analysis of randomized 
      controlled trials on stem cell therapy for KOA. Measures of efficacy included 
      Visual Analog Scale (VAS), Lequesne index, Lysholm Knee Scoring Scale (LKSS), and 
      Western Ontario and McMaster University Osteoarthritis Index (WOMAC). Joint 
      injury was evaluated through the Whole-Organ Magnetic Resonance Imaging Score 
      (WORMS) system. We analyzed 16 studies involving 875 KOA patients. The stem cell 
      treatment showed significant VAS reduction from the third month onwards. Subgroup 
      analysis suggested the most significant pain relief at different postoperative 
      months came from adipose-derived and umbilical cord-derived stem cells. 
      Autologous adipose tissue resulted in better pain alleviation compared with 
      allogenic. However, autologous bone marrow stem cells did not show increased pain 
      relief over allogeneic ones. Combination therapy (HA and/or PRP) showed no 
      effect. Autologous adipose-derived stem cells demonstrate the most effective 
      recovery of knee joint function. In WORMS assessment, there was no significant 
      difference between the stem cell group and control. Stem cell transplantation 
      proved safe and effective for KOA treatment. Different sources stem cells have a 
      good effect on alleviating knee joint pain, restoring knee joint function, and 
      minimizing patient trauma.
CI  - (c) 2023 Orthopaedic Research Society.
FAU - Xie, Rong-Hui
AU  - Xie RH
AUID- ORCID: 0000-0003-3770-3335
AD  - Department of Orthopedics, Jiujiang First People's Hospital, Jiujiang City, 
      Jiangxi Province, China.
FAU - Gong, Shi-Guo
AU  - Gong SG
AD  - Department of Orthopedics, Jiujiang First People's Hospital, Jiujiang City, 
      Jiangxi Province, China.
FAU - Song, Jiao
AU  - Song J
AD  - Department of Stomatology, Affiliated Stomatological Hospital of Jiujiang 
      College, Jiujiang City, Jiangxi Province, China.
FAU - Wu, Ping-Ping
AU  - Wu PP
AD  - Department of Dermatology, Affiliated Hospital of Jiujiang College, Jiujiang 
      City, Jiangxi Province, China.
FAU - Hu, Wen-Long
AU  - Hu WL
AD  - Department of Spine Surgery, Affiliated Hospital of Jiujiang College, Jiujiang 
      City, Jiangxi Province, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20231122
PL  - United States
TA  - J Orthop Res
JT  - Journal of orthopaedic research : official publication of the Orthopaedic 
      Research Society
JID - 8404726
SB  - IM
MH  - Humans
MH  - *Osteoarthritis, Knee/etiology
MH  - Treatment Outcome
MH  - Injections, Intra-Articular
MH  - *Mesenchymal Stem Cells
MH  - *Mesenchymal Stem Cell Transplantation/methods
MH  - Pain/etiology
OTO - NOTNLM
OT  - knee osteoarthritis
OT  - stem cell transplantation
OT  - systematic review and meta-analysis
EDAT- 2023/11/22 18:44
MHDA- 2024/03/29 06:47
CRDT- 2023/11/22 12:42
PHST- 2023/10/07 00:00 [revised]
PHST- 2023/02/17 00:00 [received]
PHST- 2023/10/16 00:00 [accepted]
PHST- 2024/03/29 06:47 [medline]
PHST- 2023/11/22 18:44 [pubmed]
PHST- 2023/11/22 12:42 [entrez]
AID - 10.1002/jor.25724 [doi]
PST - ppublish
SO  - J Orthop Res. 2024 Apr;42(4):753-768. doi: 10.1002/jor.25724. Epub 2023 Nov 22.